| Geminin is required for Hox gene regulation to pattern the developing limb. | Geminin is required for Hox gene regulation to pattern the developing limb.
Lewis EMA, Sankar S, Tong C, Patterson ES, Waller LE, Gontarz P, Zhang B, Ornitz DM, Kroll KL., Free PMC Article | 01/23/2021 |
| GemC1 and Geminin can tune the proportion of neural stem cells and ependymal cells. Findings reveal the controlled dynamic of the neurogenic niche ontogeny and identify the Geminin family members as key regulators of the initial pool of adult neural stem cells. | Adult Neural Stem Cells and Multiciliated Ependymal Cells Share a Common Lineage Regulated by the Geminin Family Members.
Ortiz-Álvarez G, Daclin M, Shihavuddin A, Lansade P, Fortoul A, Faucourt M, Clavreul S, Lalioti ME, Taraviras S, Hippenmeyer S, Livet J, Meunier A, Genovesio A, Spassky N., Free PMC Article | 11/9/2019 |
| Geminin acts as a tumor suppressor by safeguarding genome stability, whereas its overexpression is associated with genomic instability and enhanced tumorigenicity. | Geminin ablation in vivo enhances tumorigenesis through increased genomic instability.
Champeris Tsaniras S, Villiou M, Giannou AD, Nikou S, Petropoulos M, Pateras IS, Tserou P, Karousi F, Lalioti ME, Gorgoulis VG, Patmanidi AL, Stathopoulos GT, Bravou V, Lygerou Z, Taraviras S. | 10/26/2019 |
| Geminin plays important roles in pre-meiotic DNA replication and subsequent spermatogenesis. | Geminin deletion in pre-meiotic DNA replication stage causes spermatogenesis defect and infertility.
Yuan Y, Ma XS, Liang QX, Xu ZY, Huang L, Meng TG, Lin F, Schatten H, Wang ZB, Sun QY., Free PMC Article | 06/16/2018 |
| Geminin and Zic1 could cooperatively activate the expression of several shared targets encoding transcription factors that control neurogenesis, neural plate patterning, and neuronal differentiation. | Gene regulatory networks in neural cell fate acquisition from genome-wide chromatin association of Geminin and Zic1.
Sankar S, Yellajoshyula D, Zhang B, Teets B, Rockweiler N, Kroll KL., Free PMC Article | 05/19/2018 |
| Lack of Geminin promotes adult neural stem cell commitment toward the oligodendrocytic lineage at the expense of the neuronal differentiation without altering their ability to self-renew. | Geminin Participates in Differentiation Decisions of Adult Neural Stem Cells Transplanted in the Hemiparkinsonian Mouse Brain.
Taouki I, Tasiudi E, Lalioti ME, Kyrousi C, Skavatsou E, Kaplani K, Lygerou Z, Kouvelas ED, Mitsacos A, Giompres P, Taraviras S. | 04/28/2018 |
| These results provide proof-of-principle that preventing geminin function could prevent malignancy in tumors derived from pluripotent cells by selectively eliminating the progenitor cells with little harm to normal cells. | Geminin Is Essential for Pluripotent Cell Viability During Teratoma Formation, but Not for Differentiated Cell Viability During Teratoma Expansion.
Adler-Wailes DC, Kramer JA, DePamphilis ML., Free PMC Article | 09/16/2017 |
| cell penetrating (CP) Geminin is imported into the nucleus after incorporation and also the incorporated CP-Geminin directly interacted with Cdt1 or Brahma/Brg1 as the same manner as Geminin | Manipulation of Cell Cycle and Chromatin Configuration by Means of Cell-Penetrating Geminin.
Ohno Y, Suzuki-Takedachi K, Yasunaga S, Kurogi T, Santo M, Masuhiro Y, Hanazawa S, Ohtsubo M, Naka K, Takihara Y., Free PMC Article | 07/22/2017 |
| Study shows that ablation of Geminin induces massive rereplication as a result of unrestrained Cdt1 activity in embryonic stem cells, whereas it has no such effect in embryonic fibroblasts in which alternative regulation of Cdt1 activity is intact. | Geminin is an indispensable inhibitor of Cdt1 in mouse embryonic stem cells.
Hosogane M, Bosu L, Fukumoto E, Yamada H, Sato S, Nakayama K. | 04/22/2017 |
| Maternal geminin does not regulate oogenesis and oocyte meiotic maturation, but it does control accurate DNA replication and timely cleavage of fertilized eggs. | Geminin deletion in mouse oocytes results in impaired embryo development and reduced fertility.
Ma XS, Lin F, Wang ZW, Hu MW, Huang L, Meng TG, Jiang ZZ, Schatten H, Wang ZB, Sun QY., Free PMC Article | 12/17/2016 |
| Regulation of gene expression by geminin occurs only after pluripotent cells differentiate into cells in which geminin is not essential for viability. | Geminin is Essential to Prevent DNA Re-Replication-Dependent Apoptosis in Pluripotent Cells, but not in Differentiated Cells.
Huang YY, Kaneko KJ, Pan H, DePamphilis ML. | 08/6/2016 |
| Geminin is an important regulator of self-renewal and survival of enteric nervous system progenitor cells. | Inactivation of Geminin in neural crest cells affects the generation and maintenance of enteric progenitor cells, leading to enteric aganglionosis.
Stathopoulou A, Natarajan D, Nikolopoulou P, Patmanidi AL, Lygerou Z, Pachnis V, Taraviras S. | 06/28/2016 |
| geminin is indispensable for fetal hematopoiesis and regulates the generation of a physiological pool of stem and progenitor cells in the fetal hematopoietic system. | Geminin deletion increases the number of fetal hematopoietic stem cells by affecting the expression of key transcription factors.
Karamitros D, Patmanidi AL, Kotantaki P, Potocnik AJ, Bähr-Ivacevic T, Benes V, Lygerou Z, Kioussis D, Taraviras S. | 02/21/2015 |
| these data demonstrate a requirement for Geminin for neural tube patterning and neuronal differentiation during mammalian neurulation in vivo. | Geminin loss causes neural tube defects through disrupted progenitor specification and neuronal differentiation.
Patterson ES, Waller LE, Kroll KL., Free PMC Article | 11/8/2014 |
| geminin is required for Sox2 expression, and thus for the maintenance of totipotency, pluripotency and the early neural lineage. | Geminin is required for the maintenance of pluripotency.
Tabrizi GA, Böse K, Reimann Y, Kessel M., Free PMC Article | 05/10/2014 |
| geminin acts both like a component of the FGF4 signal transduction pathway that governs trophoblast proliferation and differentiation, and geminin is required to maintain endocycles. | The dual roles of geminin during trophoblast proliferation and differentiation.
de Renty C, Kaneko KJ, DePamphilis ML., Free PMC Article | 04/26/2014 |
| Data indicate that geminin supported neural differentiation. | Geminin promotes an epithelial-to-mesenchymal transition in an embryonic stem cell model of gastrulation.
Slawny N, O'Shea KS., Free PMC Article | 11/2/2013 |
| Geminin dysregulation may be restored by derepressed Hoxb4 and Hoxa9 in Scmh1-deficient mice. | Scmh1 has E3 ubiquitin ligase activity for geminin and histone H2A and regulates geminin stability directly or indirectly via transcriptional repression of Hoxa9 and Hoxb4.
Yasunaga S, Ohtsubo M, Ohno Y, Saeki K, Kurogi T, Tanaka-Okamoto M, Ishizaki H, Shirai M, Mihara K, Brock HW, Miyoshi J, Takihara Y., Free PMC Article | 03/30/2013 |
| Geminin is required during preimplantation development. Geminin knockdown inhibited the epithelial to mesenchymal transition via its ability to affect Wnt signaling and E-cadherin expression. | Geminin is required for epithelial to mesenchymal transition at gastrulation.
Emmett LS, O'Shea KS., Free PMC Article | 01/26/2013 |
| Geminin promotes the neuronal precursor cell state by modulating both the epigenetic status and expression of genes encoding neurogenesis-promoting factors. | Geminin regulates the transcriptional and epigenetic status of neuronal fate-promoting genes during mammalian neurogenesis.
Yellajoshyula D, Lim JW, Thompson DM Jr, Witt JS, Patterson ES, Kroll KL., Free PMC Article | 01/5/2013 |
| Geminin is absolutely required for mitotic proliferation of spermatogonia but does not regulate their differentiation. | Geminin is required for mitotic proliferation of spermatogonia.
Barry KA, Schultz KM, Payne CJ, McGarry TJ. | 12/8/2012 |
| Geminin regulates cortical progenitor proliferation and differentiation | Geminin regulates cortical progenitor proliferation and differentiation.
Spella M, Kyrousi C, Kritikou E, Stathopoulou A, Guillemot F, Kioussis D, Pachnis V, Lygerou Z, Taraviras S. | 11/19/2011 |
| Geminin has been shown to coordinate proliferation and differentiation by regulating cell cycle progression, chromatin organization, and transcription in the nervous system. (Review) | T cell proliferation and homeostasis: an emerging role for the cell cycle inhibitor geminin.
Karamitros D, Kotantaki P, Lygerou Z, Kioussis D, Taraviras S. | 11/12/2011 |
| Idas as a novel Geminin binding partner, implicated in cell cycle progression, and a putative regulator of proliferation-differentiation decisions during development. | Idas, a novel phylogenetically conserved geminin-related protein, binds to geminin and is required for cell cycle progression.
Pefani DE, Dimaki M, Spella M, Karantzelis N, Mitsiki E, Kyrousi C, Symeonidou IE, Perrakis A, Taraviras S, Lygerou Z., Free PMC Article | 09/10/2011 |
| Geminin antagonizes the chromatin-remodeling protein Brg1 to maintain expression of Oct4, Sox2, and Nanog. The results define a pluripotency pathway by which suppressed anaphase-promoting complex/cyclosome activity protects geminin from degradation in G1. | Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog.
Yang VS, Carter SA, Hyland SJ, Tachibana-Konwalski K, Laskey RA, Gonzalez MA., Free PMC Article | 08/27/2011 |