| Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA2 Prostanoids/TP Axis. | Prostacyclin Synthase Deficiency Leads to Exacerbation or Occurrence of Endothelium-Dependent Contraction and Causes Cardiovascular Disorders Mainly via the Non-TxA(2) Prostanoids/TP Axis.
Ge J, Zhou Y, Li H, Zeng R, Xie K, Leng J, Chen X, Yu G, Shi X, Xu Y, He D, Guo P, Zhou Y, Luo H, Luo W, Liu B. | 10/8/2024 |
| Identification of Prostaglandin I2 Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis. | Identification of Prostaglandin I(2) Synthase Rare Variants in Patients With Williams Syndrome and Severe Peripheral Pulmonary Stenosis.
Chida-Nagai A, Akagawa H, Sawai S, Ma YJ, Yakuwa S, Muneuchi J, Yasuda K, Yamazawa H, Yamamoto T, Takakuwa E, Tomaru U, Furutani Y, Kato T, Harada G, Inai K, Nakanishi T, Manabe A, Takeda A, Jing ZC., Free PMC Article | 06/3/2024 |
| Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer. | Analysis and experimental validation of fatty acid metabolism-related genes prostacyclin synthase (PTGIS) in endometrial cancer.
Wang B, Ge S, Wang Z, Wang W, Wang Y, Leng H, Ma X., Free PMC Article | 10/24/2023 |
| Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments. | Validating the role of PTGIS gene in colorectal cancer by bioinformatics analysis and in vitro experiments.
Ding H, Wang KY, Chen SY, Guo KW, Qiu WH., Free PMC Article | 10/4/2023 |
| rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS. | rRNA-Derived Small RNA rsRNA-28S Regulates the Chemoresistance of Prostate Cancer Cells by Targeting PTGIS.
Qiao D, Liu Y, Lei Y, Zhang C, Bu Y, Tang Y, Zhang Y. | 06/3/2023 |
| Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma. | Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma.
Lei K, Liang R, Tan B, Li L, Lyu Y, Wang K, Wang W, Wang K, Hu X, Wu D, Lin H, Wang M., Free PMC Article | 02/4/2023 |
| Reduced levels of prostaglandin I2 synthase: a distinctive feature of the cancer-free trichothiodystrophy. | Reduced levels of prostaglandin I(2) synthase: a distinctive feature of the cancer-free trichothiodystrophy.
Lombardi A, Arseni L, Carriero R, Compe E, Botta E, Ferri D, Uggè M, Biamonti G, Peverali FA, Bione S, Orioli D., Free PMC Article | 12/4/2021 |
| A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases. | A new insight into subinteractomes of functional antagonists: Thromboxane (CYP5A1) and prostacyclin (CYP8A1) synthases.
Ershov PV, Yablokov E, Zgoda V, Mezentsev Y, Gnedenko O, Kaluzhskiy L, Svirid A, Gilep A, Usanov SA, Ivanov A. | 11/27/2021 |
| Derivation of an induced pluripotent stem cell line (PUMCHi003-A) from a patient with pulmonary arterial hypertension carrying heterozygous mutation in PTGIS gene. | Derivation of an induced pluripotent stem cell line (PUMCHi003-A) from a patient with pulmonary arterial hypertension carrying heterozygous mutation in PTGIS gene.
Zhang SJ, Lian TY, Zhu XJ, Lu D, Xu XQ, Jiang X, Jing ZC. | 08/7/2021 |
| Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension. | Association of Rare PTGIS Variants With Susceptibility and Pulmonary Vascular Response in Patients With Idiopathic Pulmonary Arterial Hypertension.
Wang XJ, Xu XQ, Sun K, Liu KQ, Li SQ, Jiang X, Zhao QH, Wang L, Peng FH, Ye J, Wu Y, Jiang R, Zhang J, Huang W, Wei WB, Yan Y, Li JH, Liu QQ, Li S, Wang Y, Zhang SY, Zhang X, Jing ZC., Free PMC Article | 02/2/2021 |
| We identified an association between a PGIS variant and SAB risk that is modified by NSAIDs use during pregnancy and directly associated with increased levels of PGE metabolites. This suggests the potential use of genetic information to guide pharmaceutical intervention to prevent adverse pregnancy outcomes. | Nonsteroidal Anti-inflammatory Drug Interaction with Prostacyclin Synthase Protects from Miscarriage.
Velez Edwards DR, Edwards TL, Bray MJ, Torstenson E, Jones S, Shrubsole MJ, Muff HJ, Hartmann KE., Free PMC Article | 04/27/2019 |
| In examining the tumor suppressor PTGIS as a potential biomarker for treatment with either 5-Aza-dC or TSA, 5-Aza-dC effectively stabilized cell cycling, restricted genetic instability and derepressed PTGIS expression | Evaluation of Epigenetic Drug Targeting of Heterogenous Tumor Cell Fractions Using Potential Biomarkers of Response in Ovarian Cancer.
Singh AK, Chandra N, Bapat SA. | 09/3/2016 |
| Based on the predicted crystal structure of CYP8A1( *)5 using the Molecular Operating Environment platform, the distance from CYP8A1 Cys441 to the heme was altered with a significantly changed binding free energy for the mutant protein. | Analysis of genetic polymorphism and biochemical characterization of a functionally decreased variant in prostacyclin synthase gene (CYP8A1) in humans.
Cho SA, Rohn-Glowacki KJ, Jarrar YB, Yi M, Kim WY, Shin JG, Lee SJ. | 06/27/2015 |
| results indicate that PGIS expression was associated with radiotherapy efficiency | Prostacyclin-synthase expression in head and neck carcinoma patients and its prognostic value in the response to radiotherapy.
Camacho M, Piñeiro Z, Alcolea S, García J, Balart J, Terra X, Avilés-Jurado FX, Soler M, Quer M, León X, Vila L. | 03/21/2015 |
| Type-2 diabetes is associated with higher COX-2 expression, but lower eNOS and PGIS expression in subcutaneous arteries. | Reduced expression of prostacyclin synthase and nitric oxide synthase in subcutaneous arteries of type 2 diabetic patients.
Safiah Mokhtar S, M Vanhoutte P, W S Leung S, Imran Yusof M, Wan Sulaiman WA, Zaharil Mat Saad A, Suppian R, Ghulam Rasool AH. | 07/12/2014 |
| In a case-control study unaffected carriers of a BMPR2 mutation, linked to pulmonary artery hypertension (PAH), were most often found to have prostacyclin synthase promoter sequence variants, which were thought to protect against PAH. | Functional prostacyclin synthase promoter polymorphisms. Impact in pulmonary arterial hypertension.
Stearman RS, Cornelius AR, Lu X, Conklin DS, Del Rosario MJ, Lowe AM, Elos MT, Fettig LM, Wong RE, Hara N, Cogan JD, Phillips JA 3rd, Taylor MR, Graham BB, Tuder RM, Loyd JE, Geraci MW., Free PMC Article | 07/5/2014 |
| These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts. | VEGF expression is augmented by hypoxia‑induced PGIS in human fibroblasts.
Wang J, Ikeda R, Che XF, Ooyama A, Yamamoto M, Furukawa T, Hasui K, Zheng CL, Tajitsu Y, Oka T, Tabata S, Nishizawa Y, Eizuru Y, Akiyama S. | 04/12/2014 |
| High PTGIS expression is associated with colorectal cancer hepatic metastasis. | Combination of haptoglobin and osteopontin could predict colorectal cancer hepatic metastasis.
Sun L, Pan J, Peng L, Fang L, Zhao X, Sun L, Yang Z, Ran Y. | 10/27/2012 |
| The CC genotype of C1117A polymorphism is associated with higher risk of LM-CAD | CYP8A1 gene polymorphisms and left main coronary artery disease.
Bousoula E, Kolovou V, Vasiliadis I, Karakosta A, Xanthos T, Johnson EO, Skandalakis P, Kolovou GD. | 09/8/2012 |
| Overexpression of PTGIS is associated with liver metastasis in colon cancer. | Overexpression of PTGIS could predict liver metastasis and is correlated with poor prognosis in colon cancer patients.
Lichao S, Liang P, Chunguang G, Fang L, Zhihua Y, Yuliang R. | 09/1/2012 |
| diabetes preferentially increases PGIS nitration that is associated with excessive vascular inflammation in atherosclerotic carotid arteries from patients with type 2 diabetes | Enhanced tyrosine nitration of prostacyclin synthase is associated with increased inflammation in atherosclerotic carotid arteries from type 2 diabetic patients.
He C, Choi HC, Xie Z., Free PMC Article | 01/1/2011 |
| downregulated in endometriosis tissues | DNA microarray analysis in a mouse model for endometriosis and validation of candidate factors with human adenomyosis.
Kusakabe KT, Abe H, Kondo T, Kato K, Okada T, Otsuki Y. | 11/27/2010 |
| Review: PGI2 function depends on the different alleles of the PTGIS gene and that they may influence the risk of cardiovascular disease. | Genetic polymorphisms of prostacyclin synthase gene and cardiovascular disease.
Nakayama T. | 07/12/2010 |
| PGIS overexpression apparently protects insulin-producing cells against cytokine toxicity via suppression of endoplasmic reticulum and mitochondrial stress-mediated cell death pathways | Protection against cytokine toxicity through endoplasmic reticulum and mitochondrial stress prevention by prostacyclin synthase overexpression in insulin-producing cells.
Gurgul-Convey E, Lenzen S., Free PMC Article | 05/10/2010 |
| MI is associated with the CC genotype of rs5629 in the human CYP8A1 gene. The A-C-T haplotype appears to be a useful genetic marker and the C-T-T haplotype might be a protective factor of MI in Chinese people. | Haplotype analysis of the CYP8A1 gene associated with myocardial infarction.
Xiang Xie, Ma YT, Fu ZY, Yang YN, Xiang Ma, Chen BD, Wang YH, Fen Liu. | 03/15/2010 |