| PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis. | PTGER3 knockdown inhibits the vulnerability of triple-negative breast cancer to ferroptosis.
Wang S, Zhang Y, Zhang D, Meng J, Che N, Zhao X, Liu T., Free PMC Article | 07/8/2024 |
| E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation. | E prostanoid receptor-3 promotes oxidized low-density lipoprotein-induced human aortic smooth muscle cells inflammation.
Hu CJ, Wang YW, Huang WX, Xia YB., Free PMC Article | 03/30/2023 |
| Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome. | Altered Prostaglandin E Receptor Subtype 3 Expression in Lacrimal Glands of Patients with Chronic Stevens-Johnson Syndrome.
Singh S, Rao BS, Basu S. | 02/22/2023 |
| PGE2 -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase. | PGE(2) -EP3 axis promotes brown adipose tissue formation through stabilization of WTAP RNA methyltransferase.
Tao X, Du R, Guo S, Feng X, Yu T, OuYang Q, Chen Q, Fan X, Wang X, Guo C, Li X, Xue F, Chen S, Tong M, Lazarus M, Zuo S, Yu Y, Shen Y., Free PMC Article | 08/27/2022 |
| Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss. | Prostaglandin E2 receptor 3 promotes M1 macrophages polarization in unexplained recurrent pregnancy loss.
Ye Y, Peng L, Chelariu-Raicu A, Kuhn C, Dong X, Jeschke U, von Schönfeldt V. | 05/28/2022 |
| Prostaglandin E2 EP receptors in cardiovascular disease: An update. | Prostaglandin E2 EP receptors in cardiovascular disease: An update.
Bryson TD, Harding P. | 01/22/2022 |
| EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases. | EP3 Is an Independent Prognostic Marker Only for Unifocal Breast Cancer Cases.
Zati Zehni A, Jeschke U, Hester A, Kolben T, Ditsch N, Jacob SN, Mumm JN, Heidegger HH, Mahner S, Vilsmaier T., Free PMC Article | 03/20/2021 |
| EP3 and uPAR could represent novel therapeutic targets in the treatment of cervical cancer in advantaged stages. | Prostaglandin E2 receptor 3 (EP3) signaling promotes migration of cervical cancer via urokinase-type plasminogen activator receptor (uPAR).
Ye Y, Peng L, Vattai A, Deuster E, Kuhn C, Dannecker C, Mahner S, Jeschke U, von Schönfeldt V, Heidegger HH., Free PMC Article | 08/12/2020 |
| These results suggest that PGE2 regulates human brain endothelial cell migration via cooperation of EP2, EP3, and EP4 receptors. | PGE(2) -induced migration of human brain endothelial cell is mediated though protein kinase A in cooperation of EP receptors.
Khan GA, Bhagat S, Alam MI. | 05/9/2020 |
| Prostaglandin E2 -EP3 receptor subtype gene deletion in mother and son impairs platelet aggregation. | Prostaglandin E(2) -EP(3) receptor subtype gene deletion in mother and son impairs platelet aggregation.
Goharian TS, Fagerberg CR, Jensen BL, Graakjaer J, Brasch-Andersen C, Nybo M. | 01/4/2020 |
| our results demonstrate that PGE2 activates TRPM7 via EP3/PKA signalling pathway, and that PGE2 enhances migration and proliferation of human glioblastoma cells by up-regulation of the TRPM7 channel. | Prostaglandin E2 increases migration and proliferation of human glioblastoma cells by activating transient receptor potential melastatin 7 channels.
Tian Y, Yang T, Yu S, Liu C, He M, Hu C., Free PMC Article | 11/2/2019 |
| The potential prognostic relevance of EP3 expression for OS in TA-MUC1 negative patients might reflect an interplay between the COX and the MUC1 pathway, as it has been shown that MUC1 could induce COX2 expression. | EP3 receptor is a prognostic factor in TA-MUC1-negative ovarian cancer.
Czogalla B, Kuhn C, Heublein S, Schmöckel E, Mayr D, Kolben T, Trillsch F, Burges A, Mahner S, Jeschke U, Hester A. | 10/5/2019 |
| These findings identify PTGER3 as a potential therapeutic target in chemoresistant ovarian cancers expressing high levels of this oncogenic protein | PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis.
Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Chavez-Reyes A, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G., Free PMC Article | 06/29/2019 |
| Single nucleotide polymorphism association analysis showed that the Toll-like receptor 3 (TLR3), prostaglandin-E receptor 3 (PTGER3), and IKZF1 gene were significantly associated with cold medicine-Stevens-Johnson syndrome and toxic epidermal necrolysis with severe ocular complications. | Results of Detailed Investigations Into Stevens-Johnson Syndrome With Severe Ocular Complications.
Ueta M. | 05/18/2019 |
| EP3 crystal structure reveals a completely enclosed binding pocket containing a structured water molecule and provides a description of the action of prostaglandins. | Crystal structure of misoprostol bound to the labor inducer prostaglandin E(2) receptor.
Audet M, White KL, Breton B, Zarzycka B, Han GW, Lu Y, Gati C, Batyuk A, Popov P, Velasquez J, Manahan D, Hu H, Weierstall U, Liu W, Shui W, Katritch V, Cherezov V, Hanson MA, Stevens RC., Free PMC Article | 05/11/2019 |
| EP3 crystal structure reveals important insights into the activation mechanism of EP3 receptor. | Crystal structure of the endogenous agonist-bound prostanoid receptor EP3.
Morimoto K, Suno R, Hotta Y, Yamashita K, Hirata K, Yamamoto M, Narumiya S, Iwata S, Kobayashi T. | 05/11/2019 |
| Low EP3 expression is associated with cervical dysplasia. | The role of EP3-receptor expression in cervical dysplasia.
Hester A, Ritzer M, Kuhn C, Schmoeckel E, Mayr D, Kolben T, Dannecker C, Mahner S, Jeschke U, Kolben TM. | 03/2/2019 |
| BRS-3 and EP3 interact to potentiate PGE2 signaling. This potentiating effect is receptor specific, and it occurs only when BRS-3 is paired to EP3. | Receptor-specific crosstalk between prostanoid E receptor 3 and bombesin receptor subtype 3.
Zhang Y, Liu Y, Wu L, Fan C, Wang Z, Zhang X, Alachkar A, Liang X, Civelli O., Free PMC Article | 01/19/2019 |
| In sporadic breast cancer, EP3 receptor expression is not significantly associated with clinicopathological parameters but is a significant prognostic factor for improved progression-free and overall survival. However, the functional aspects of EP3 receptor in breast cancer and the way how EP3 may oppose the pro-tumorigenic effects of PGE2 elevation and COX-2 overexpression are not fully understood so far. | EP3 (prostaglandin E2 receptor 3) expression is a prognostic factor for progression-free and overall survival in sporadic breast cancer.
Semmlinger A, von Schoenfeldt V, Wolf V, Meuter A, Kolben TM, Kolben T, Zeder-Goess C, Weis F, Gallwas J, Wuerstlein R, Hermelink K, Schmoeckel E, Harbeck N, Mayr D, Mahner S, Jeschke U, Ditsch N., Free PMC Article | 10/20/2018 |
| Study reports that EP3 expression is elevated in TSC2- deficient patient-derived cells compared with TSC2-addback cells, and that EP3 antagonist selectively suppresses the proliferation of TSC2-deficient cells. The elevated expression of EP3 is mediated by Rheb in an mTORC1-independent fashion. | Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells.
Li C, Liu X, Liu Y, Zhang E, Medepalli K, Masuda K, Li N, Wikenheiser-Brokamp KA, Osterburg A, Borchers MT, Kopras EJ, Plas DR, Sun J, Franz DN, Capal JK, Mays M, Sun Y, Kwiatkowski DJ, Alayev A, Holz MK, Krueger DA, Siroky BJ, Yu JJ. | 06/23/2018 |
| Study showed the EP3 expression is correlated to the FIGO classification and, demonstrates that an increased EP3 expression correlates with a negative outcome of overall survival of cervical carcinoma patients. In addition, different expression of EP3 was found in correlation to the histological subtype. Patients with adenocarcinoma and high expression of EP3 had a worse outcome survival. | The Prostaglandin EP3 Receptor Is an Independent Negative Prognostic Factor for Cervical Cancer Patients.
Heidegger H, Dietlmeier S, Ye Y, Kuhn C, Vattai A, Aberl C, Jeschke U, Mahner S, Kost B., Free PMC Article | 04/28/2018 |
| EP2 and EP3 receptors are involved in tolerance induction through IL-10 production by tol-DCs. | Up-regulation of EP(2) and EP(3) receptors in human tolerogenic dendritic cells boosts the immunosuppressive activity of PGE(2).
Flórez-Grau G, Cabezón R, Borgman KJE, España C, Lozano JJ, Garcia-Parajo MF, Benítez-Ribas D. | 10/7/2017 |
| Its signaling pathway impairs hippocampal presynaptic long-term plasticity in Alzheimer's disease. | PGE(2)-EP3 signaling pathway impairs hippocampal presynaptic long-term plasticity in a mouse model of Alzheimer's disease.
Maingret V, Barthet G, Deforges S, Jiang N, Mulle C, Amédée T. | 10/7/2017 |
| findings show that prostaglandin E2 EP3 receptor contributes to thrombin-induced brain damage via Rho-Rho kinase-mediated cytotoxicity and proinflammatory responses. | Inhibition of prostaglandin E2 receptor EP3 mitigates thrombin-induced brain injury.
Han X, Lan X, Li Q, Gao Y, Zhu W, Cheng T, Maruyama T, Wang J., Free PMC Article | 08/12/2017 |
| S211L within EP3 is the key residue to distinguish PGE1 and PGE2 binding to mediate diverse biological functions at the initial recognition step | The key residue within the second extracellular loop of human EP3 involved in selectively turning down PGE(2)- and retaining PGE(1)-mediated signaling in live cells.
Akasaka H, Thaliachery N, Zheng X, Blumenthal M, Nikhar S, Murdoch EE, Ling Q, Ruan KH. | 05/20/2017 |