| CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling. | CRISPR/Cas9-mediated Bag-1 knockout increased mesenchymal characteristics of MCF-7 cells via Akt hyperactivation-mediated actin cytoskeleton remodeling.
Kilbas PO, Can ND, Kizilboga T, Ezberci F, Doganay HL, Arisan ED, Dinler Doganay G., Free PMC Article | 02/12/2022 |
| Mutation of the BAG-1 domain decreases its protective effect against hypoxia/reoxygenation by regulating HSP70 and the PI3K/AKT signalling pathway in SY-SH5Y cells. | Mutation of the BAG-1 domain decreases its protective effect against hypoxia/reoxygenation by regulating HSP70 and the PI3K/AKT signalling pathway in SY-SH5Y cells.
Chen Y, Wang K, Di J, Guan C, Wang S, Li Q, Qu Y. | 12/4/2021 |
| Bag-1L Protects against Cell Apoptosis in an In Vitro Model of Lung Ischemia-Reperfusion Injury through the C-Terminal ""Bag"" Domain. | Bag-1L Protects against Cell Apoptosis in an In Vitro Model of Lung Ischemia-Reperfusion Injury through the C-Terminal "Bag" Domain.
Lv JL, Shi LN, Zhai CY, Wang GJ, Qu Y., Free PMC Article | 09/25/2021 |
| Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma. | Integrated case-control and somatic-germline interaction analyses of soft-tissue sarcoma.
Hu F, Yu Y, Chen JS, Hu H, Scheet P, Huff CD. | 09/4/2021 |
| Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders. | Genes involved in glucocorticoid receptor signalling affect susceptibility to mood disorders.
Szczepankiewicz D, Narożna B, Celichowski P, Sakrajda K, Kołodziejski P, Banach E, Zakowicz P, Pruszyńska-Oszmałek E, Pawlak J, Wiłkość M, Dmitrzak-Węglarz M, Skibińska M, Bejger A, Twarowska-Hauser J, Rybakowski JK, Nogowski L, Szczepankiewicz A. | 08/21/2021 |
| Inhibition of BAG-1 induced SH-SY5Y cell apoptosis without affecting Hsp70 expression. | Inhibition of BAG-1 induced SH-SY5Y cell apoptosis without affecting Hsp70 expression.
Song YK, Li Z, Wang Y, Qu Y, Li QS, Man XY, Wang FT, Hu D. | 05/15/2021 |
| Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics. | Expression of BAG1 is associated with prognosis in kidney renal clear cell carcinoma based on bioinformatics.
Wu H, Liu M, He Y, Meng G, Guo W, Guo Q., Free PMC Article | 05/15/2021 |
| Co-Chaperone Bag-1 Plays a Role in the Autophagy-Dependent Cell Survival through Beclin 1 Interaction. | Co-Chaperone Bag-1 Plays a Role in the Autophagy-Dependent Cell Survival through Beclin 1 Interaction.
Turk M, Tatli O, Alkan HF, Ozfiliz Kilbas P, Alkurt G, Dinler Doganay G., Free PMC Article | 05/15/2021 |
| The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to the G-quadruplex of the BAG-1 5'UTR. | The Small Nuclear Ribonucleoprotein Polypeptide A (SNRPA) binds to the G-quadruplex of the BAG-1 5'UTR.
Bolduc F, Turcotte MA, Perreault JP. | 01/9/2021 |
| Bag-1 is overexpressed in breast tumors in all molecular subtypes. Bag-1 forms complexes with B-Raf, C-Raf and Akt in breast cancer cells, enhancing their phosphorylation and activation, and ultimately leading to phosphorylation of the pro-apoptotic Bad protein at Ser112 and Ser136. This causes Bad's re-localization to the nucleus, and inhibits apoptosis in favor of cell survival. | Bag-1 stimulates Bad phosphorylation through activation of Akt and Raf kinases to mediate cell survival in breast cancer.
Kizilboga T, Baskale EA, Yildiz J, Akcay IM, Zemheri E, Can ND, Ozden C, Demir S, Ezberci F, Dinler-Doganay G., Free PMC Article | 05/9/2020 |
| We demonstrated a critical role for the rG4 in the control of both cap-dependent and independent translation of the BAG-1 mRNA in colorectal cancer cells. Additionally, we found an upstream ORF that also represses BAG-1 mRNA translation | G-quadruplex located in the 5'UTR of the BAG-1 mRNA affects both its cap-dependent and cap-independent translation through global secondary structure maintenance.
Jodoin R, Carrier JC, Rivard N, Bisaillon M, Perreault JP., Free PMC Article | 12/14/2019 |
| Study in human osteosarcoma line U2OS expressing a conditional MYC-ER allele revealed that small isoform of BAG1, BAG1S, in cooperation with the HSP70 chaperone complex, selectively mediates cell survival in MYC overexpressing tumor cells and identified a set of specific pro-survival clients controlled by the HSP70/BAG1S chaperone complex. | Interaction between the BAG1S isoform and HSP70 mediates the stability of anti-apoptotic proteins and the survival of osteosarcoma cells expressing oncogenic MYC.
Gennaro VJ, Wedegaertner H, McMahon SB., Free PMC Article | 07/20/2019 |
| Bag-1 targeted therapy might enhance the therapeutic potential of conventional anti-cancer drugs in the treatment of breast cancer. | Bag-1 silencing enhanced chemotherapeutic drug-induced apoptosis in MCF-7 breast cancer cells affecting PI3K/Akt/mTOR and MAPK signaling pathways.
Kilbas PO, Akcay IM, Doganay GD, Arisan ED. | 07/13/2019 |
| BAG1, CHMP2B, PEX3, and WIPI1 confirmed a strong differential gene expression, in 355 melanoma samples. | WIPI1, BAG1, and PEX3 Autophagy-Related Genes Are Relevant Melanoma Markers.
D'Arcangelo D, Giampietri C, Muscio M, Scatozza F, Facchiano F, Facchiano A., Free PMC Article | 03/23/2019 |
| Targeting mTOR with rapamycin may significantly potentiate the inhibitory effect in BAG1silenced cells. | Downregulation of BAG‑1 in T47D cells promotes resistance to tamoxifen via activation of the PI3K/Akt/mTOR signaling pathway.
Lu S, Du Y, Cui F, Feng X, Ma Y, Liu H. | 03/9/2019 |
| Here the authors show that the AF-1 domain of AR is bound by the cochaperone Bag-1L. | Development of Bag-1L as a therapeutic target in androgen receptor-dependent prostate cancer.
Cato L, Neeb A, Sharp A, Buzón V, Ficarro SB, Yang L, Muhle-Goll C, Kuznik NC, Riisnaes R, Nava Rodrigues D, Armant O, Gourain V, Adelmant G, Ntim EA, Westerling T, Dolling D, Rescigno P, Figueiredo I, Fauser F, Wu J, Rottenberg JT, Shatkina L, Ester C, Luy B, Puchta H, Troppmair J, Jung N, Bräse S, Strähle U, Marto JA, Nienhaus GU, Al-Lazikani B, Salvatella X, de Bono JS, Cato AC, Brown M., Free PMC Article | 06/2/2018 |
| Over expression of BAG-1 may be a biomarker for cisplatin resistance in patients with primary or recurrent head and neck squamous cell carcinoma. | Over-expression of BAG-1 in head and neck squamous cell carcinomas (HNSCC) is associated with cisplatin-resistance.
Liu S, Ren B, Gao H, Liao S, Zhai YX, Li S, Su XJ, Jin P, Stroncek D, Xu Z, Zeng Q, Li Y., Free PMC Article | 05/26/2018 |
| Increased BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signaling. | An increase in BAG-1 by PD-L1 confers resistance to tyrosine kinase inhibitor in non-small cell lung cancer via persistent activation of ERK signalling.
Lin PL, Wu TC, Wu DW, Wang L, Chen CY, Lee H. | 10/28/2017 |
| BAG-4/SODD, HSP70, and HSP90 are potential prognostic markers in node-negative breast carcinoma that merit further research. | BAG-1/SODD, HSP70, and HSP90 are potential prognostic markers of poor survival in node-negative breast carcinoma.
Davidson B, Valborg Reinertsen K, Trinh D, Reed W, Bøhler PJ. | 08/19/2017 |
| interaction with Bag1 then shifts hERG degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2, as determined by siRNA screening | Bag1 Co-chaperone Promotes TRC8 E3 Ligase-dependent Degradation of Misfolded Human Ether a Go-Go-related Gene (hERG) Potassium Channels.
Hantouche C, Williamson B, Valinsky WC, Solomon J, Shrier A, Young JC., Free PMC Article | 07/8/2017 |
| These results suggest that Bag1 and Bag3 control the stability of the Hsc70-client complex using at least two distinct protein-protein contacts, providing a previously under-appreciated layer of molecular regulation in the human Hsc70 system. | Non-canonical Interactions between Heat Shock Cognate Protein 70 (Hsc70) and Bcl2-associated Anthanogene (BAG) Co-Chaperones Are Important for Client Release.
Rauch JN, Zuiderweg ER, Gestwicki JE., Free PMC Article | 05/20/2017 |
| Taken together, these data indicate that Bag-1 up-regulation is required to maintain apoptosis resistance in human cytomegalovirus-infected cells. | Human cytomegalovirus inhibits apoptosis involving upregulation of the antiapoptotic protein Bag-1.
Li HP, Yuan CL, Zho YC. | 05/28/2016 |
| the combined effects of BAG-1 and XPD polymorphisms on chemotherapy sensitivity and survival in patients with advanced non-small-cell lung cancer, which might be the important predictive markers for platinum-based chemotherapy efficacy. | Association between polymorphisms of BAG-1 and XPD and chemotherapy sensitivity in advanced non-small-cell lung cancer patients treated with vinorelbine combined cisplatin regimen.
Li P, Wang YD, Cheng J, Chen JC, Ha MW. | 04/23/2016 |
| Bag-1 indirectly affects cell survival through c-Myc activated signalling that causes elevation of ornithine decarboxylase levels, leading to an increase of the polyamine content. | Bag-1 promotes cell survival through c-Myc-mediated ODC upregulation that is not preferred under apoptotic stimuli in MCF-7 cells.
Ozfiliz P, Kizilboga T, Demir S, Alkurt G, Palavan-Unsal N, Arisan ED, Dinler-Doganay G. | 02/6/2016 |
| Overexpression of miR-138 inhibited cell proliferation by directly suppressing the expression of Bag-1. | MiR-138 Suppresses Cell Proliferation by Targeting Bag-1 in Gallbladder Carcinoma.
Ma F, Zhang M, Gong W, Weng M, Quan Z., Free PMC Article | 02/6/2016 |