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    PTEN phosphatase and tensin homolog [ Homo sapiens (human) ]

    Gene ID: 5728, updated on 6-Oct-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Rs12039395 Variant Influences the Expression of hsa-miR-181a-5p and PTEN Toward Colorectal Cancer Risk.

    Rs12039395 Variant Influences the Expression of hsa-miR-181a-5p and PTEN Toward Colorectal Cancer Risk.
    El-Korany WA, Zahran WE, Alm El-Din MA, Al-Shenawy HA, Soliman AF.

    09/29/2024
    RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.

    RNA-binding protein GIGYF2 orchestrates hepatic insulin resistance through STAU1/PTEN-mediated disruption of the PI3K/AKT signaling cascade.
    Lv Z, Ren Y, Li Y, Niu F, Li Z, Li M, Li X, Li Q, Huang D, Yu Y, Xiong Y, Qian L., Free PMC Article

    09/24/2024
    A retrospective analysis suggests PTEN expression is associated with favorable clinicopathological features of breast cancer.

    A retrospective analysis suggests PTEN expression is associated with favorable clinicopathological features of breast cancer.
    Derkyi-Kwarteng L, Ghartey FN, Aidoo E, Addae E, Imbeah EG, Brown AA, Acquah S., Free PMC Article

    09/24/2024
    The Role of PTEN in Chemoresistance Mediated by the HIF-1alpha/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia.

    The Role of PTEN in Chemoresistance Mediated by the HIF-1α/YY1 Axis in Pediatric Acute Lymphoblastic Leukemia.
    Antonio-Andres G, Morales-Martinez M, Jimenez-Hernandez E, Huerta-Yepez S., Free PMC Article

    09/3/2024
    A miRNA-21-Mediated PTEN/Akt/NF-kappaB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis.

    A miRNA-21-Mediated PTEN/Akt/NF-κB Axis Promotes Chronic Obstructive Pulmonary Disease Pathogenesis.
    Sai X, Qin C, Zhang Z, Yu H, Bian T., Free PMC Article

    08/26/2024
    Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m[6]A-modified PTEN mRNA in pancreatic ductal adenocarcinoma.

    Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m(6)A-modified PTEN mRNA in pancreatic ductal adenocarcinoma.
    Zheng D, Chen W, Peng J, Huang X, Zhang S, Zhuang Y.

    08/19/2024
    CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.

    CBLL1 promotes endometrial stromal cell senescence via inhibiting PTEN in recurrent spontaneous abortion.
    Liu X, Wei X, Wu J, Xu Y, Hu J, Qin C, Chen C, Lin Y.

    08/14/2024
    Non-canonical function of nuclear PTEN and its implication on tumorigenesis.

    Non-canonical function of nuclear PTEN and its implication on tumorigenesis.
    Misra S, Ghosh G, Chowdhury SG, Karmakar P.

    07/29/2024
    The NTE domain of PTENalpha/beta promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.

    The NTE domain of PTENα/β promotes cancer progression by interacting with WDR5 via its SSSRRSS motif.
    Huang X, Zhang C, Shang X, Chen Y, Xiao Q, Wei Z, Wang G, Zhen X, Xu G, Min J, Shen S, Liu Y., Free PMC Article

    07/16/2024
    [Genetic analysis of a Chinese pedigree affected with Cowden syndrome due to variant of PTEN gene].

    [Genetic analysis of a Chinese pedigree affected with Cowden syndrome due to variant of PTEN gene].
    Peng Z, Zhang C.

    07/2/2024
    Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.

    Thyroid nodules with DICER1 mutation or PTEN alteration: A comparative cytologic, clinical, and molecular study of 117 FNA cases.
    Jitpasutham T, Andrianus S, Gubbiotti M, Nosé V, Baloch ZW, Madrigal E, Faquin WC.

    06/11/2024
    PTEN hamartoma tumor syndrome: Clinical and genetic characterization in pediatric patients.

    PTEN hamartoma tumor syndrome: Clinical and genetic characterization in pediatric patients.
    Martín-Valbuena J, Gestoso-Uzal N, Justel-Rodríguez M, Isidoro-García M, Marcos-Vadillo E, Lorenzo-Hernández SM, Criado-Muriel MC, Prieto-Matos P., Free PMC Article

    05/29/2024
    miR-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K/Akt signaling pathway.

    miR-30a-5p attenuates hypoxia/reoxygenation-induced cardiomyocyte apoptosis by regulating PTEN protein expression and activating PI3K/Akt signaling pathway.
    Liang G, Guo C, Tang H, Zhang M., Free PMC Article

    05/29/2024
    FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression.

    FBXO32-mediated degradation of PTEN promotes lung adenocarcinoma progression.
    Wu J, Wen T, Marzio A, Song D, Chen S, Yang C, Zhao F, Zhang B, Zhao G, Ferri A, Cheng H, Ma J, Ren H, Chen QY, Yang Y, Qin S., Free PMC Article

    05/22/2024
    SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis.

    SNHG4-mediated PTEN destabilization confers oxaliplatin resistance in colorectal cancer cells by inhibiting ferroptosis.
    Li SQ, Xu WT, Yin YX, Wei HT, Li KZ, Xie MZ, Lv F, Xie LY, Hu BL.

    05/8/2024
    Effect of stability of PTEN on hepatocellular carcinoma.

    Effect of stability of PTEN on hepatocellular carcinoma.
    Hu Y, Mei H, Luan T, Sun H, Lu Q, Liu R.

    05/3/2024
    Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review.

    Therapeutic role of PTEN in tissue regeneration for management of neurological disorders: stem cell behaviors to an in-depth review.
    Li Y, Ma R, Hao X., Free PMC Article

    04/22/2024
    Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.

    Combined deletion of MEN1, ATRX and PTEN triggers development of high-grade pancreatic neuroendocrine tumors in mice.
    Fuentes ME, Lu X, Flores NM, Hausmann S, Mazur PK., Free PMC Article

    04/17/2024
    Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.

    Cancer and Autism: How PTEN Mutations Degrade Function at the Membrane and Isoform Expression in the Human Brain.
    Jang H, Chen J, Iakoucheva LM, Nussinov R.,

    04/8/2024
    Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production.

    Cancer-associated fibroblasts drive colorectal cancer cell progression through exosomal miR-20a-5p-mediated targeting of PTEN and stimulating interleukin-6 production.
    Ghofrani-Shahpar M, Pakravan K, Razmara E, Amooie F, Mahmoudian M, Heshmati M, Babashah S., Free PMC Article

    04/5/2024
    PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.

    PTEN deficiency potentiates HBV-associated liver cancer development through augmented GP73/GOLM1.
    Huang F, Guo J, Zhao N, Hou M, Gai X, Yang S, Cai P, Wang Y, Ma Q, Zhao Q, Li L, Yang H, Jing Y, Jin D, Hu Z, Zha X, Wang H, Mao Y, Liu F, Zhang H., Free PMC Article

    03/27/2024
    Cerebellar phenotypes in germline PTEN mutation carriers.

    Cerebellar phenotypes in germline PTEN mutation carriers.
    Gambini D, Ferrero S, Bulfamante G, Pisani L, Corbo M, Kuhn E.

    03/22/2024
    Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.

    Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.
    Huang Y, Wu Z, Peng Z, Liu A, Yuan W, Han D, Peng J., Free PMC Article

    03/20/2024
    PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFR[L858R]-induced lung cancer progression.

    PTEN decreases NR2F1 expression to inhibit ciliogenesis during EGFR(L858R)-induced lung cancer progression.
    Tran TTT, Hung JJ., Free PMC Article

    03/20/2024
    PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.

    PINK1-PTEN axis promotes metastasis and chemoresistance in ovarian cancer via non-canonical pathway.
    Zheng F, Zhong J, Chen K, Shi Y, Wang F, Wang S, Tang S, Yuan X, Shen Z, Tang S, Xia D, Wu Y, Lu W., Free PMC Article

    03/15/2024
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