| Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys. | Adhesion G Protein-Coupled Receptor Gpr126 (Adgrg6) Expression Profiling in Diseased Mouse, Rat, and Human Kidneys.
Kösters P, Cazorla-Vázquez S, Krüger R, Daniel C, Vonbrunn E, Amann K, Engel FB., Free PMC Article | 09/10/2024 |
| Analysis of GPR126 polymorphisms and their relationship with scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican patients. | Analysis of GPR126 polymorphisms and their relationship with scoliosis in Marfan syndrome and Marfan-like syndrome in Mexican patients.
Soto ME, Fuentevilla-Alvarez G, Koretzky SG, Vargas-Alarcón G, Torres-Paz YE, Meza-Toledo SE, Pérez-Torres I, Huesca-Gómez C, Gamboa R., Free PMC Article | 11/8/2023 |
| The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells. | The COPD GWAS gene ADGRG6 instructs function and injury response in human iPSC-derived type II alveolar epithelial cells.
Werder RB, Berthiaume KA, Merritt C, Gallagher M, Villacorta-Martin C, Wang F, Bawa P, Malik V, Lyons SM, Basil MC, Morrisey EE, Kotton DN, Zhou X, Cho MH, Wilson AA., Free PMC Article | 11/3/2023 |
| Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney. | Adhesion GPCR Gpr126 (Adgrg6) Expression Profiling in Zebrafish, Mouse, and Human Kidney.
Cazorla-Vázquez S, Kösters P, Bertz S, Pfister F, Daniel C, Dedden M, Zundler S, Jobst-Schwan T, Amann K, Engel FB., Free PMC Article | 08/14/2023 |
| Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression. | Noncoding SNP at rs1663689 represses ADGRG6 via interchromosomal interaction and reduces lung cancer progression.
Lei X, Tian X, Wang H, Xu X, Li G, Liu W, Wang D, Xiao Z, Zhang M, Li MJ, Zhang Z, Ma Z, Liu Z., Free PMC Article | 07/12/2023 |
| Progesterone activates GPR126 to promote breast cancer development via the Gi pathway. | Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P, Zhang P, Yu X, Sun JP., Free PMC Article | 05/14/2022 |
| Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome. | Genomic characterization of the adolescent idiopathic scoliosis-associated transcriptome and regulome.
Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu J, Rios J, Gray RS, Wise CA, Ahituv N., Free PMC Article | 09/11/2021 |
| Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells. | Functional genomics of GPR126 in airway smooth muscle and bronchial epithelial cells.
Hall RJ, O'Loughlin J, Billington CK, Thakker D, Hall IP, Sayers I. | 07/24/2021 |
| GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression. | GPR126 regulates colorectal cancer cell proliferation by mediating HDAC2 and GLI2 expression.
Cui H, Yu W, Yu M, Luo Y, Yang M, Cong R, Chu X, Gao G, Zhong M., Free PMC Article | 05/15/2021 |
| A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126). | A synthetic method to assay adhesion-family G-protein coupled receptors. Determination of the G-protein coupling profile of ADGRG6(GPR126).
Lizano E, Hayes JL, Willard FS. | 04/24/2021 |
| Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population | Asymmetric expression of GPR126 in the convex/concave side of the spine is associated with spinal skeletal malformation in adolescent idiopathic scoliosis population.
Xu E, Lin T, Jiang H, Ji Z, Shao W, Meng Y, Gao R, Zhou X. | 08/12/2020 |
| modulation of gpr126 expression in zebrafish by injection of either miR-27b or miR-27b inhibitor in single cell-stage embryos resulted in hypo- or hypertrabeculation, respectively | miR-27a/b is a posttranscriptional regulator of Gpr126 (Adgrg6).
Musa G, Srivastava S, Petzold J, Cazorla-Vázquez S, Engel FB. | 05/9/2020 |
| data demonstrate that the newly generated lacZ reporter mouse is a suitable model to study Gpr126 expression during development and adulthood, provide detailed insight into Gpr126 expression at the cellular level, and reveal that all identified Gpr126-expressing cells are known to be exposed to mechanical stimuli | Gpr126 (Adgrg6) is expressed in cell types known to be exposed to mechanical stimuli.
Musa G, Cazorla-Vázquez S, van Amerongen MJ, Stemmler MP, Eckstein M, Hartmann A, Braun T, Brabletz T, Engel FB. | 05/9/2020 |
| Alternative splicing regulates ECR conformation and receptor signaling, while mutagenesis of the calcium-binding site abolishes Gpr126 function in vivo. These results demonstrate that Gpr126 ECR utilizes a multi-faceted dynamic approach to regulate receptor function and provide relevant insights for ECR-targeted drug design. | Structural basis for adhesion G protein-coupled receptor Gpr126 function.
Leon K, Cunningham RL, Riback JA, Feldman E, Li J, Sosnick TR, Zhao M, Monk KR, Araç D., Free PMC Article | 04/4/2020 |
| The role of GPR126 in radial sorting and myelination in Schwann cells suggests a mechanism of pathogenesis for intellectual disability (ID). Involvement of GPR126 in lethal congenital contracture syndrome 9 has been identified previously, but this is the first report of a plausible candidate gene, GPR126, in ID. | GPR126: A novel candidate gene implicated in autosomal recessive intellectual disability.
Hosseini M, Fattahi Z, Abedini SS, Hu H, Ropers HH, Kalscheuer VM, Najmabadi H, Kahrizi K. | 02/15/2020 |
| In NMIBC, somatic GPR126 noncoding mutations occurred in 47.7% of samples and were negatively associated with GPR126 mRNA levels. GPR126 mutations had higher frequencies in nonsmoker patients and were associated with a prior history of NMIBC. GPR126 overexpression was detected in 70.5% of samples. | High Prevalence of a Hotspot of Noncoding Somatic Mutations in Intron 6 of GPR126 in Bladder Cancer.
Garinet S, Pignot G, Vacher S, Le Goux C, Schnitzler A, Chemlali W, Sirab N, Barry Delongchamps N, Zerbib M, Sibony M, Allory Y, Damotte D, Bieche I. | 02/1/2020 |
| The analysis included a total of 6,873 cases and 38,916 controls and yielded significant association (combined P = 2.95 x 10(-20); odds ratio = 1.22), providing convincing evidence of the worldwide association between rs6570507 and adolescent idiopathic scoliosis susceptibility. In silico analyses strongly suggested that GPR126 is a susceptibility gene at this locus. | A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis.
Kou I, Watanabe K, Takahashi Y, Momozawa Y, Khanshour A, Grauers A, Zhou H, Liu G, Fan YH, Takeda K, Ogura Y, Zhou T, Iwasaki Y, Kubo M, Wu Z, Matsumoto M, Japan Scoliosis Clinical Research Group (JSCRG), Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), Einarsdottir E, Kere J, Huang D, Qiu G, Qiu Y, Wise CA, Song YQ, Wu N, Su P, Gerdhem P, Ikegawa S., Free PMC Article | 10/26/2019 |
| GPR126 single nucleotide polymorphisms rs225694, rs7774095 and rs2294773 are significantly associated with adolescent idiopathic scoliosis in Northern Chinese Han patients. | Genetic polymorphisms of GPR126 are functionally associated with PUMC classifications of adolescent idiopathic scoliosis in a Northern Han population.
Liu G, Liu S, Lin M, Li X, Chen W, Zuo Y, Liu J, Niu Y, Zhao S, Long B, Wu Z, Wu N, Qiu G., Free PMC Article | 10/19/2019 |
| Gene expression analysis of ADGRG6 in human lung tissue revealed a decreased expression in patients with chronic obstructive pulmonary disease | Heritability and genome-wide association study of diffusing capacity of the lung.
Terzikhan N, Sun F, Verhamme FM, Adams HHH, Loth D, Bracke KR, Stricker BHC, Lahousse L, Dupuis J, Brusselle GG, O'Connor GT. | 08/3/2019 |
| Chondrogenic differentiation experiment showed that GPR126-exon6(in) has a high expression level relative to GPR126-exon6(ex) during chondrogenic differentiation of hMSCs. Our findings indicate that newly discovered SNP is related to cartilage development and may provide valuable insights into the etiology and pathogenesis of adolescent idiopathic scoliosis. | A Genetic Variant in GPR126 Causing a Decreased Inclusion of Exon 6 Is Associated with Cartilage Development in Adolescent Idiopathic Scoliosis Population.
Xu E, Shao W, Jiang H, Lin T, Gao R, Zhou X., Free PMC Article | 07/20/2019 |
| The genetic variants in EPAS1, GPR126 may contribute to the physiological adaptations to hypobaric hypoxia, possibly by altering lung function. | Evidence of Early-Stage Selection on EPAS1 and GPR126 Genes in Andean High Altitude Populations.
Eichstaedt CA, Pagani L, Antao T, Inchley CE, Cardona A, Mörseburg A, Clemente FJ, Sluckin TJ, Metspalu E, Mitt M, Mägi R, Hudjashov G, Metspalu M, Mormina M, Jacobs GS, Kivisild T., Free PMC Article | 06/29/2019 |
| SNPs of the GPR126 gene were functionally associated with adolescent idiopathic scoliosis in a Chinese population. | Genetic Variant of GPR126 Gene is Functionally Associated With Adolescent Idiopathic Scoliosis in Chinese Population.
Qin X, Xu L, Xia C, Zhu W, Sun W, Liu Z, Qiu Y, Zhu Z. | 06/8/2019 |
| Authors find recurrent ADGRG6 enhancer mutations and FRS2 duplications which are associated with higher protein expression in the tumor and poor prognosis. Functional assays demonstrate that depletion of ADGRG6 or FRS2 expression in UBC cells compromise their abilities to recruit endothelial cells and induce tube formation. | Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer.
Wu S, Ou T, Xing N, Lu J, Wan S, Wang C, Zhang X, Yang F, Huang Y, Cai Z., Free PMC Article | 04/13/2019 |
| The association of a single nucleotide polymorphism in GPR126 with aggressive periodontitis in a Japanese population. The role of GPR126 in maintaining the homeostasis of periodontal ligament tissues. | A Putative Association of a Single Nucleotide Polymorphism in GPR126 with Aggressive Periodontitis in a Japanese Population.
Kitagaki J, Miyauchi S, Asano Y, Imai A, Kawai S, Michikami I, Yamashita M, Yamada S, Kitamura M, Murakami S., Free PMC Article | 08/26/2017 |
| Together, these data uncover Gpr126 as a genetic cause for the pathogenesis of Adolescent idiopathic scoliosis (AIS) and pectus excavatum in a mouse model. | Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice.
Karner CM, Long F, Solnica-Krezel L, Monk KR, Gray RS., Free PMC Article | 05/21/2016 |