| Identification of a novel compound heterozygous mutation and a homozygous mutation of SLURP1 in Chinese families with Mal de Meleda. | Identification of a novel compound heterozygous mutation and a homozygous mutation of SLURP1 in Chinese families with Mal de Meleda.
Wang T, Tang Z, Xiao T, Ren J, He S, Liu Y, Xiao S, Wang X., Free PMC Article | 07/3/2023 |
| Endogenous alpha7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier. | Endogenous α7 nAChR Agonist SLURP1 Facilitates Escherichia coli K1 Crossing the Blood-Brain Barrier.
He X, Wang L, Liu L, Gao J, Long B, Chi F, Hu T, Wan Y, Gong Z, Li L, Zhen P, Zhang T, Cao H, Huang SH., Free PMC Article | 01/15/2022 |
| Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis. | Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis.
Shulepko MA, Bychkov ML, Shenkarev ZO, Kulbatskii DS, Makhonin AM, Paramonov AS, Chugunov AO, Kirpichnikov MP, Lyukmanova EN. | 12/18/2021 |
| Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors. | Structural Diversity and Dynamics of Human Three-Finger Proteins Acting on Nicotinic Acetylcholine Receptors.
Paramonov AS, Kocharovskaya MV, Tsarev AV, Kulbatskii DS, Loktyushov EV, Shulepko MA, Kirpichnikov MP, Lyukmanova EN, Shenkarev ZO., Free PMC Article | 03/6/2021 |
| Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells. | Recombinant Analogue of the Human Protein SLURP-1 Inhibits the Growth of U251 MG and A172 Glioma Cells.
Shulepko MA, Bychkov ML, Lyukmanova EN, Kirpichnikov MP. | 02/20/2021 |
| these results elucidate the beneficial effects of SLURP1 in stabilizing the Human Corneal Limbal Epithelial intercellular junctions. | The secreted Ly-6/uPAR related protein-1 (SLURP1) stabilizes epithelial cell junctions and suppresses TNF-α-induced cytokine production.
Campbell G, Swamynathan S, Tiwari A, Swamynathan SK., Free PMC Article | 06/20/2020 |
| Slurp1 regulate the synthesis pathway of Triglycerides through Sfrp5 in hepatocyte steatosis model. | Sfrp5 interacts with Slurp1 to regulate the accumulation of triglycerides in hepatocyte steatosis model.
Zhao A, Jiang F, Yang G, Liu H, Li L. | 02/8/2020 |
| More than 20 genes have been reported to be associated with PPKs including desmoglein 1 (DSG1) a key molecular component for epidermal adhesion and differentiation. Mal de Meleda (MDM) is a rare inherited autosomal recessive genodermatosis characterized by transgrediens PPK, associated with mutations in the secreted LY6/PLAUR domain containing 1 (SLURP1) gene. | Novel nonsense variants in SLURP1 and DSG1 cause palmoplantar keratoderma in Pakistani families.
Akbar A, Prince C, Payne C, Fasham J, Ahmad W, Baple EL, Crosby AH, Harlalka GV, Gul A., Free PMC Article | 12/7/2019 |
| SLURP1 immunostaining is significantly increased in lesional skin of psoriasis vulgaris and not in psoriasiform dermatitis, which demonstrates the role of SLURP1 in the pathogenesis of psoriasis | Lesional upregulation of SLURP1 immunostaining parallels disease severity in psoriasis vulgaris patients.
Assaf M, Salah E. | 08/31/2019 |
| SLURPs inhibit growth of epithelial cancer cells in vitro and merit further investigation as potential agents for anticancer therapy | Human secreted proteins SLURP-1 and SLURP-2 control the growth of epithelial cancer cells via interactions with nicotinic acetylcholine receptors.
Lyukmanova EN, Bychkov ML, Sharonov GV, Efremenko AV, Shulepko MA, Kulbatskii DS, Shenkarev ZO, Feofanov AV, Dolgikh DA, Kirpichnikov MP., Free PMC Article | 08/10/2019 |
| Our results are discussed in the context of recent studies on heterologously produced SLURP-1 and indicate that N-terminal extensions of SLURP-1 may affect its activity and selectivity on its targets. In this respect, synthetic SLURP-1 appears to be a better probe for structure-function studies. | Interaction of Synthetic Human SLURP-1 with the Nicotinic Acetylcholine Receptors.
Durek T, Shelukhina IV, Tae HS, Thongyoo P, Spirova EN, Kudryavtsev DS, Kasheverov IE, Faure G, Corringer PJ, Craik DJ, Adams DJ, Tsetlin VI., Free PMC Article | 07/13/2019 |
| These findings strongly suggest that down regulation of SLURP1 expression may be implicated in the pathogenesis of various solid tumors, particularly malignancies of squamous lineage, and thus this gene may be a squamous lineage-specific tumor suppressor. | SLURP-1 is mutated in Mal de Meleda, a potential molecular signature for melanoma and a putative squamous lineage tumor suppressor gene.
Bergqvist C, Kadara H, Hamie L, Nemer G, Safi R, Karouni M, Marrouche N, Abbas O, Hasbani DJ, Kibbi AG, Nassar D, Shimomura Y, Kurban M. | 08/11/2018 |
| This is the first mal de Meleda case of Javanese ethnicity to be documented, and the unique mutation has not previously been reported. | Identification of novel homozygous SLURP1 mutation in a Javanese family with Mal de Meleda.
Radiono S, Pramono ZAD, Oh GGK, Surana U, Widiyani S, Danarti R. | 06/16/2018 |
| We identified a mutation in SLURP1 in five members of a consanguineous family in Pakistan, who had Mal de Meleda. | A novel homozygous mutation disrupting the initiation codon in the SLURP1 gene underlies mal de Meleda in a consanguineous family.
Shah K, Nasir A, Irfanullah, Shahzad S, Khan S, Ahmad W. | 01/20/2018 |
| novel splice site mutation c.58+5G>T in mal de Meleda in India | A novel mutation in SLURP1 in patients with mal de Meleda from the Indian subcontinent.
Nellen RG, Claessens T, Subramaniam R, Betkerur J, Prashanth A, Steijlen PM, van Geel M. | 10/1/2016 |
| Results of this study suggest understand Mal de Meleda, it will be important to identify proteins that interact with mutatated SLURP1. In any such studies, it will be important to assess binding of mutant SLURP1 proteins that cause Mal de Meleda. | Heterogeneity in the properties of mutant secreted lymphocyte antigen 6/urokinase receptor-related protein 1 (SLURP1) in Mal de Meleda.
Adeyo O, Oberer M, Ploug M, Fong LG, Young SG, Beigneux AP., Free PMC Article | 09/17/2016 |
| To our knowledge, the present study is the fi rst report on molecular investigation of Mal de Meleda from Libya. | The first Mal de Meleda case in Libya: identification of a SLURP1 mutation.
Bchetnia M, Bozgia M, Laroussi N, Ben Brick AS, Charfeddine C, Ben Halim N, Mokni M, Boubaker MS, Abdelhak S. | 09/3/2016 |
| This supports the hypothesis that the antiproliferative activity of SLURP-1 is related to 'metabotropic' signaling pathway through alpha7-nAChR, that activates intracellular signaling cascades without opening the receptor channel. | Human Secreted Ly-6/uPAR Related Protein-1 (SLURP-1) Is a Selective Allosteric Antagonist of α7 Nicotinic Acetylcholine Receptor.
Lyukmanova EN, Shulepko MA, Kudryavtsev D, Bychkov ML, Kulbatskii DS, Kasheverov IE, Astapova MV, Feofanov AV, Thomsen MS, Mikkelsen JD, Shenkarev ZO, Tsetlin VI, Dolgikh DA, Kirpichnikov MP., Free PMC Article | 07/16/2016 |
| SLURP1 participates in pathophysiology of psoriasis by regulating keratinocyte proliferation and differentiation, and by suppressing the growth of S. aureus | IL-22/STAT3-Induced Increases in SLURP1 Expression within Psoriatic Lesions Exerts Antimicrobial Effects against Staphylococcus aureus.
Moriwaki Y, Takada K, Nagasaki T, Kubo N, Ishii T, Kose K, Kageyama T, Tsuji S, Kawashima K, Misawa H., Free PMC Article | 06/11/2016 |
| Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda. | Palmoplantar keratoderma of the Gamborg-Nielsen type is caused by mutations in the SLURP1 gene and represents a variant of Mal de Meleda.
Zhao L, Vahlquist A, Virtanen M, Wennerstrand L, Lind LK, Lundström A, Hellström Pigg M. | 07/25/2015 |
| rSLURP-1 decreased production of TNFalpha by T-cells, downregulated IL-1 beta and IL-6 secretion by macrophages, and moderately upregulated IL-10 production by both types of immunocytes | Anti-inflammatory effects of the nicotinergic peptides SLURP-1 and SLURP-2 on human intestinal epithelial cells and immunocytes.
Chernyavsky AI, Galitovskiy V, Shchepotin IB, Grando SA., Free PMC Article | 02/14/2015 |
| This report further expands the spectrum of clinical phenotypes associated with mutations in SLURP1 in the Mediterranean population. | Particular Mal de Meleda phenotypes in Tunisia and mutations founder effect in the Mediterranean region.
Bchetnia M, Laroussi N, Youssef M, Charfeddine C, Ben Brick AS, Boubaker MS, Mokni M, Abdelhak S, Zili J, Benmously R., Free PMC Article | 06/7/2014 |
| mutations in SLURP1 as a cause for mal de Meleda and suggest an ancient founder effect for p.W15R in the western European population. | Haplotype analysis in western European patients with mal de Meleda: founder effect for the W15R mutation in the SLURP1 gene.
Nellen RG, Steijlen PM, Hennies HC, Fischer J, Munro CS, Jonkman MF, van Steensel MA, van Geel M. | 03/1/2014 |
| Those findings suggested that SLURP-1 and stimulus through alpha7 nicotinic ACh receptors actively controlled asthmatic condition by stimulating ciliary beating and also by suppressing airway inflammation. | Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells.
Narumoto O, Niikura Y, Ishii S, Morihara H, Okashiro S, Nakahari T, Nakano T, Matsumura H, Shimamoto C, Moriwaki Y, Misawa H, Yamashita N, Nagase T, Kawashima K, Yamashita N. | 11/16/2013 |
| The pro-oncogenic effects of tobacco nitrosamine (4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone) can be abolished, in part, by rSLURP-1 that also upregulated RUNX3. | Reciprocal effects of NNK and SLURP-1 on oncogene expression in target epithelial cells.
Kalantari-Dehaghi M, Bernard HU, Grando SA., Free PMC Article | 01/26/2013 |