| PLXDC1 serves as a potential prognostic marker and involves in malignant progression and macrophage polarization in colon cancer. | PLXDC1 serves as a potential prognostic marker and involves in malignant progression and macrophage polarization in colon cancer.
Fu Y, Zhang X, Qiao Q. | 11/5/2024 |
| Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV). | Plxdc family members are novel receptors for the rhesus monkey rhadinovirus (RRV).
Großkopf AK, Schlagowski S, Fricke T, Ensser A, Desrosiers RC, Hahn AS., Free PMC Article | 07/24/2021 |
| Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients | Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.
Pietrzyk Ł, Wdowiak P. | 04/18/2020 |
| Study revealed that over-expression of PLXDC1 per se was able to change partly the growth features of U87MG glioblastoma cells. Molecularly, PLXDC1 regulated the epithelial to mesenchymal transition program of tumor cells, whereby its silencing increased the mRNA levels of epithelial transcripts, whereas those of mesenchymal marker genes were reduced. | Glioblastoma endothelium drives bevacizumab-induced infiltrative growth via modulation of PLXDC1.
Falchetti ML, D'Alessandris QG, Pacioni S, Buccarelli M, Morgante L, Giannetti S, Lulli V, Martini M, Larocca LM, Vakana E, Stancato L, Ricci-Vitiani L, Pallini R., Free PMC Article | 06/8/2019 |
| PLXDC1 silencing by the HA-CH-NP/siRNA significantly inhibited tumor growth in A2780 tumor-bearing mice. | Selective delivery of PLXDC1 small interfering RNA to endothelial cells for anti-angiogenesis tumor therapy using CD44-targeted chitosan nanoparticles for epithelial ovarian cancer.
Kim GH, Won JE, Byeon Y, Kim MG, Wi TI, Lee JM, Park YY, Lee JW, Kang TH, Jung ID, Shin BC, Ahn HJ, Lee YJ, Sood AK, Han HD, Park YM., Free PMC Article | 10/20/2018 |
| Immunohistochemical analysis of 122 gliomas showed that TGLI1 expression was positively correlated with VEGF-C, TEM7 and microvessel density. | The gain-of-function GLI1 transcription factor TGLI1 enhances expression of VEGF-C and TEM7 to promote glioblastoma angiogenesis.
Carpenter RL, Paw I, Zhu H, Sirkisoon S, Xing F, Watabe K, Debinski W, Lo HW., Free PMC Article | 08/6/2016 |
| PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. | Identification of PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF.
Cheng G, Zhong M, Kawaguchi R, Kassai M, Al-Ubaidi M, Deng J, Ter-Stepanian M, Sun H., Free PMC Article | 09/12/2015 |
| TEM-7 is a vascular protein associated with angiogenic states. TEM-7 is a novel and attractive target for antiangiogenic therapy. | Tumor endothelial marker 7 (TEM-7): a novel target for antiangiogenic therapy.
Bagley RG, Rouleau C, Weber W, Mehraein K, Smale R, Curiel M, Callahan M, Roy A, Boutin P, St Martin T, Nacht M, Teicher BA. | 03/17/2012 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| All osteosarcoma cell lines, 6/9 tumors but none of the bone specimens expressed mRNA of TEM7 secreted forms 1 and 2. | Preferential expression of the secreted and membrane forms of tumor endothelial marker 7 transcripts in osteosarcoma.
Halder C, Ossendorf C, Maran A, Yaszemski M, Bolander ME, Fuchs B, Sarkar G., Free PMC Article | 02/1/2010 |
| TEM7 may play significant role in proliferation and maintenance of neovascular endothelial cells in fibrovascular membranes. TEM7 may be molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy. | TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy.
Yamaji Y, Yoshida S, Ishikawa K, Sengoku A, Sato K, Yoshida A, Kuwahara R, Ohuchida K, Oki E, Enaida H, Fujisawa K, Kono T, Ishibashi T. | 01/21/2010 |
| TEM7 expression level closely parallels histology-based prognostication of OGS metastasis and, therefore, it is a therapeutic target. | High expression of tumor endothelial marker 7 is associated with metastasis and poor survival of patients with osteogenic sarcoma.
Fuchs B, Mahlum E, Halder C, Maran A, Yaszemski M, Bode B, Bolander M, Sarkar G., Free PMC Article | 01/21/2010 |