| Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm. | Regulation of matrix reloading by tumor endothelial marker 1 protects against abdominal aortic aneurysm.
Hong YK, Cheng TL, Hsu CK, Lee FT, Chang BI, Wang KC, Chang LY, Wu HL, Lai CH., Free PMC Article | 08/9/2024 |
| IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer. | IL-8 from CD248-expressing cancer-associated fibroblasts generates cisplatin resistance in non-small cell lung cancer.
Wu J, Zhang Q, Wu J, Yang Z, Liu X, Lou C, Wang X, Peng J, Zhang J, Shang Z, Xiao J, Wang N, Zhang R, Zhou J, Wang Y, Hu Z, Zhang R, Zhang J, Zeng Z., Free PMC Article | 03/8/2024 |
| TEM1/endosialin/CD248 promotes pathologic scarring and TGF-beta activity through its receptor stability in dermal fibroblasts. | TEM1/endosialin/CD248 promotes pathologic scarring and TGF-β activity through its receptor stability in dermal fibroblasts.
Hong YK, Lin YC, Cheng TL, Lai CH, Chang YH, Huang YL, Hung CY, Wu CH, Hung KS, Ku YC, Ho YT, Tang MJ, Lin SW, Shi GY, McGrath JA, Wu HL, Hsu CK., Free PMC Article | 02/12/2024 |
| [Expression of endosialin in human hypertrophic scars and its regulation on fibroblast phenotype]. | [Expression of endosialin in human hypertrophic scars and its regulation on fibroblast phenotype].
Zhang QY, Zhang LX, Han DH, Jiao XC, Zheng Z, Guo K, Yang YS. | 01/3/2024 |
| Inflammatory Mesenchymal Stem Cells Express Abundant Membrane-Bound and Soluble Forms of C-Type Lectin-like CD248. | Inflammatory Mesenchymal Stem Cells Express Abundant Membrane-Bound and Soluble Forms of C-Type Lectin-like CD248.
Payet M, Ah-Pine F, Guillot X, Gasque P., Free PMC Article | 06/13/2023 |
| Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8[+] T cells in clear cell renal cell carcinoma. | Endosialin-positive tumor-derived pericytes promote tumor progression through impeding the infiltration of CD8(+) T cells in clear cell renal cell carcinoma.
Lu T, Zhang J, Lu S, Yang F, Gan L, Wu X, Song H, Liu S, Xu C, Han D, Yang B, Wen W, Qin W, Yang L., Free PMC Article | 05/30/2023 |
| Fibroblast expression of CD248 may contribute to exacerbation of microvascular damage during systemic sclerosis. | Fibroblast expression of CD248 may contribute to exacerbation of microvascular damage during systemic sclerosis.
Cipriani P, Ruscitti P, Di Cola I, Vomero M, Abbruzzese F, Di Nino E, Ross R, Del Galdo F, Giacomelli R. | 03/8/2023 |
| CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer. | CD248 Regulates Wnt Signaling in Pericytes to Promote Angiogenesis and Tumor Growth in Lung Cancer.
Hong CL, Yu IS, Pai CH, Chen JS, Hsieh MS, Wu HL, Lin SW, Huang HP. | 10/22/2022 |
| Placental and plasma early predictive biomarkers for gestational diabetes mellitus. | Placental and plasma early predictive biomarkers for gestational diabetes mellitus.
Wei Y, He A, Huang Z, Liu J, Li R. | 07/23/2022 |
| Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling. | Tumor endothelial marker 1 is upregulated in heart after cardiac injury and participates in cardiac remodeling.
Chen PS, Feng WH, Tsai TH, Hong YK, Lee AS, Chang KC, Chung HC, Liu YW, Hsieh CC, Fang YH, Yang PJ, Luo CY, Liu PY, Cheng TL, Li YH., Free PMC Article | 07/2/2022 |
| Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice. | Role of tumor endothelial marker 1 (Endosialin/CD248) lectin-like domain in lipopolysaccharide-induced macrophage activation and sepsis in mice.
Cheng TL, Lin YS, Hong YK, Ma CY, Tsai HW, Shi GY, Wu HL, Lai CH. | 08/7/2021 |
| In addition to EIF2AK4, which has been already suggested to be associated with pulmonary veno-occlusive disease, we identified the novel candidate genes ATP13A3, CD248, EFCAB4B, involved in lung vascular remodeling that represent reliable drivers contributing to the disease according to their biological functions/inheritance patterns | A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial Hypertension.
Barozzi C, Galletti M, Tomasi L, De Fanti S, Palazzini M, Manes A, Sazzini M, Galiè N., Free PMC Article | 07/25/2020 |
| Data show that endosialin protein (CD248) gene silencing as well as miR-125b-5p overexpression markedly reversed drug resistance and inhibited epithelial-mesenchymal transition in colon cancer cells. | Modified TLR-mediated downregulation of miR-125b-5p enhances CD248 (endosialin)-induced metastasis and drug resistance in colorectal cancer cells.
Park GB, Jeong JY, Kim D. | 04/25/2020 |
| CD248 contributes to tumor growth, fibrosis, and neoplastic angiogenesis. (Review) | Linking myofibroblast generation and microvascular alteration: The role of CD248 from pathogenesis to therapeutic target (Review).
Di Benedetto P, Ruscitti P, Liakouli V, Del Galdo F, Giacomelli R, Cipriani P. | 01/11/2020 |
| CD248 exerts detrimental effects on WAT phenotype and systemic glucose homeostasis which may be reversed by suppression of adipocyte CD248. Therefore, CD248 may constitute a target to treat obesity-associated co-morbidities. | Specific loss of adipocyte CD248 improves metabolic health via reduced white adipose tissue hypoxia, fibrosis and inflammation.
Petrus P, Fernandez TL, Kwon MM, Huang JL, Lei V, Safikhan NS, Karunakaran S, O'Shannessy DJ, Zheng X, Catrina SB, Albone E, Laine J, Virtanen K, Clee SM, Kieffer TJ, Noll C, Carpentier AC, Johnson JD, Rydén M, Conway EM., Free PMC Article | 12/14/2019 |
| These findings identify novel protein interactions involving CLEC14A, CD93 and CD248 with MMRN2 as targetable components of vessel formation | Multimerin-2 is a ligand for group 14 family C-type lectins CLEC14A, CD93 and CD248 spanning the endothelial pericyte interface.
Khan KA, Naylor AJ, Khan A, Noy PJ, Mambretti M, Lodhia P, Athwal J, Korzystka A, Buckley CD, Willcox BE, Mohammed F, Bicknell R., Free PMC Article | 11/26/2017 |
| Data show that podoplanin (PDPN), CD106 (VCAM-1) and CD248 protein were increased in diseased compared to healthy tendon cells. | Persistent stromal fibroblast activation is present in chronic tendinopathy.
Dakin SG, Buckley CD, Al-Mossawi MH, Hedley R, Martinez FO, Wheway K, Watkins B, Carr AJ., Free PMC Article | 11/11/2017 |
| the data demonstrate a critical role for endosialin-expressing primary tumor pericytes in mediating metastatic dissemination and identify endosialin as a promising therapeutic target in breast cancer | Endosialin-Expressing Pericytes Promote Metastatic Dissemination.
Viski C, König C, Kijewska M, Mogler C, Isacke CM, Augustin HG. | 07/22/2017 |
| Endosialin is a potential regulator of phenotypic remodeling of vascular smooth muscle cells contributing to atherosclerosis. | Endosialin Promotes Atherosclerosis Through Phenotypic Remodeling of Vascular Smooth Muscle Cells.
Hasanov Z, Ruckdeschel T, König C, Mogler C, Kapel SS, Korn C, Spegg C, Eichwald V, Wieland M, Appak S, Augustin HG. | 06/24/2017 |
| Tumour cell endosialin expression was seen in 89% of undifferentiated pleomorphic sarcomas, 77% of adult fibrosarcomas/spindle cell sarcomas, 62% of synovial sarcomas, 51% of leiomyosarcomas and 31% of rhabdomyosarcomas. | Endosialin expression in soft tissue sarcoma as a potential marker of undifferentiated mesenchymal cells.
Thway K, Robertson D, Jones RL, Selfe J, Shipley J, Fisher C, Isacke CM., Free PMC Article | 05/27/2017 |
| CD248 overexpression is possibly involved in the pathogenesis of IPF and it has potential as a disease severity marker. | Role of CD248 as a potential severity marker in idiopathic pulmonary fibrosis.
Bartis D, Crowley LE, D'Souza VK, Borthwick L, Fisher AJ, Croft AP, Pongrácz JE, Thompson R, Langman G, Buckley CD, Thickett DR., Free PMC Article | 01/14/2017 |
| TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer | TEM1 expression in cancer-associated fibroblasts is correlated with a poor prognosis in patients with gastric cancer.
Fujii S, Fujihara A, Natori K, Abe A, Kuboki Y, Higuchi Y, Aizawa M, Kuwata T, Kinoshita T, Yasui W, Ochiai A., Free PMC Article | 09/17/2016 |
| MORAb-004 reduced CD248 on pericytes, impaired tumor microvasculature maturation and ultimately suppressed tumor development. | Targeting endosialin/CD248 through antibody-mediated internalization results in impaired pericyte maturation and dysfunctional tumor microvasculature.
Rybinski K, Imtiyaz HZ, Mittica B, Drozdowski B, Fulmer J, Furuuchi K, Fernando S, Henry M, Chao Q, Kline B, Albone E, Wustner J, Lin J, Nicolaides NC, Grasso L, Zhou Y., Free PMC Article | 07/30/2016 |
| The authors show that endosialin, a C-type lectin, expressed in the liver exclusively by HSC and portal fibroblasts, is upregulated in liver fibrosis in mouse and man. | Hepatic stellate cell-expressed endosialin balances fibrogenesis and hepatocyte proliferation during liver damage.
Mogler C, Wieland M, König C, Hu J, Runge A, Korn C, Besemfelder E, Breitkopf-Heinlein K, Komljenovic D, Dooley S, Schirmacher P, Longerich T, Augustin HG., Free PMC Article | 11/7/2015 |
| The genes CD248, Ephb1 and P2RY2 were detected as the top overexpressed in GC biopsies. | Increased expression of P2RY2, CD248 and EphB1 in gastric cancers from Chilean patients.
Aquea G, Bresky G, Lancellotti D, Madariaga JA, Zaffiri V, Urzua U, Haberle S, Bernal G. | 12/20/2014 |