| Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS. | Adipose triglyceride lipase suppresses noncanonical inflammasome by hydrolyzing LPS.
Li W, Liu Q, Qian Y, Wang C, Kong C, Sun L, Sun L, Liu H, Zhang Y, Jiang D, Jiang C, Wang S, Xia P. | 10/31/2024 |
| Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort. | Association between Polymorphism rs61876744 in PNPLA2 Gene and Keratoconus in a Saudi Cohort.
Kondkar AA, Azad TA, Sultan T, Khatlani T, Alshehri AA, Lobo GP, Kalantan H, Al-Obeidan SA, Al-Muammar AM., Free PMC Article | 01/3/2024 |
| ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression. | ATGL promotes colorectal cancer growth by regulating autophagy process and SIRT1 expression.
Su BC, Xiao KM, Wang KL, Yang SF, Huang ZX, Luo JW. | 11/14/2023 |
| BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells. | BETi enhance ATGL expression and its lipase activity to exert their antitumoral effects in triple-negative breast cancer (TNBC) cells.
Rossi T, Zamponi R, Chirico M, Pisanu ME, Iorio E, Torricelli F, Gugnoni M, Ciarrocchi A, Pistoni M., Free PMC Article | 01/14/2023 |
| ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids. | ATGL is a biosynthetic enzyme for fatty acid esters of hydroxy fatty acids.
Patel R, Santoro A, Hofer P, Tan D, Oberer M, Nelson AT, Konduri S, Siegel D, Zechner R, Saghatelian A, Kahn BB., Free PMC Article | 07/9/2022 |
| Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences. | Resting skeletal muscle PNPLA2 (ATGL) and CPT1B are associated with peak fat oxidation rates in men and women but do not explain observed sex differences.
Chrzanowski-Smith OJ, Edinburgh RM, Smith E, Thomas MP, Walhin JP, Koumanov F, Williams S, Betts JA, Gonzalez JT. | 04/9/2022 |
| The Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure. | The Role of Adipose Triglyceride Lipase and Cytosolic Lipolysis in Cardiac Function and Heart Failure.
Kintscher U, Foryst-Ludwig A, Haemmerle G, Zechner R., Free PMC Article | 02/26/2022 |
| Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection. | Burkholderia pseudomallei interferes with host lipid metabolism via NR1D2-mediated PNPLA2/ATGL suppression to block autophagy-dependent inhibition of infection.
Tang M, Hu Z, Rao C, Chen J, Yuan S, Zhang J, Mao C, Yan J, Xia Y, Zhang M, Yue J, Xiang Y, Xie J, Mao X, Li Q., Free PMC Article | 01/22/2022 |
| Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice. | Hepatocyte-specific deletion of adipose triglyceride lipase (adipose triglyceride lipase/patatin-like phospholipase domain containing 2) ameliorates dietary induced steatohepatitis in mice.
Fuchs CD, Radun R, Dixon ED, Mlitz V, Timelthaler G, Halilbasic E, Herac M, Jonker JW, Ronda OAHO, Tardelli M, Haemmerle G, Zimmermann R, Scharnagl H, Stojakovic T, Verkade HJ, Trauner M. | 01/15/2022 |
| Dietary fat content and adipose triglyceride lipase and hormone-sensitive lipase gene expressions in adults' subcutaneous and visceral fat tissues. | Dietary fat content and adipose triglyceride lipase and hormone-sensitive lipase gene expressions in adults' subcutaneous and visceral fat tissues.
Zareie R, Yuzbashian E, Rahimi H, Asghari G, Zarkesh M, Hedayati M, Djazayery A, Movahedi A, Mirmiran P, Khalaj A. | 12/4/2021 |
| Association of the PNPLA2, SCD1 and Leptin Expression with Fat Distribution in Liver and Adipose Tissue From Obese Subjects. | Association of the PNPLA2, SCD1 and Leptin Expression with Fat Distribution in Liver and Adipose Tissue From Obese Subjects.
Cruz-Color L, Hernández-Nazará ZH, Maldonado-González M, Navarro-Muñíz E, Domínguez-Rosales JA, Torres-Baranda JR, Ruelas-Cinco EDC, Ramírez-Meza SM, Ruíz-Madrigal B. | 10/16/2021 |
| Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway. | Adipose triglyceride lipase promotes the proliferation of colorectal cancer cells via enhancing the lipolytic pathway.
Yin H, Li W, Mo L, Deng S, Lin W, Ma C, Luo Z, Luo C, Hong H., Free PMC Article | 09/25/2021 |
| Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells. | Loss of ephrin B2 receptor (EPHB2) sets lipid rheostat by regulating proteins DGAT1 and ATGL inducing lipid droplet storage in prostate cancer cells.
Morales A, Greenberg M, Nardi F, Gil V, Hayward SW, Crawford SE, Franco OE., Free PMC Article | 09/11/2021 |
| Downregulation of adipose triglyceride lipase by EB viral-encoded LMP2A links lipid accumulation to increased migration in nasopharyngeal carcinoma. | Downregulation of adipose triglyceride lipase by EB viral-encoded LMP2A links lipid accumulation to increased migration in nasopharyngeal carcinoma.
Zheng S, Matskova L, Zhou X, Xiao X, Huang G, Zhang Z, Ernberg I., Free PMC Article | 09/4/2021 |
| Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes. | Association between PNPLA2 Gene Polymorphisms and the Risk of Diabetic Kidney Disease in a Chinese Han Population with Type 2 Diabetes.
Zhao H, Zhang H, Wang Y, Zhao T, Yan M, Dong X, Wang Q, Li J, Ma L, Li P., Free PMC Article | 05/29/2021 |
| Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals. | Decoration of myocellular lipid droplets with perilipins as a marker for in vivo lipid droplet dynamics: A super-resolution microscopy study in trained athletes and insulin resistant individuals.
Gemmink A, Daemen S, Brouwers B, Hoeks J, Schaart G, Knoops K, Schrauwen P, Hesselink MKC. | 04/24/2021 |
| Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer. | Hypoxia, hypoxia-inducible gene 2 (HIG2)/HILPDA, and intracellular lipolysis in cancer.
Povero D, Johnson SM, Liu J., Free PMC Article | 03/28/2021 |
| Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling. | Adipose triglyceride lipase activity regulates cancer cell proliferation via AMP-kinase and mTOR signaling.
Xie H, Heier C, Kien B, Vesely PW, Tang Z, Sexl V, Schoiswohl G, Strießnig-Bina I, Hoefler G, Zechner R, Schweiger M., Free PMC Article | 01/2/2021 |
| Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis. | Protein-protein interactions regulate the activity of Adipose Triglyceride Lipase in intracellular lipolysis.
Kulminskaya N, Oberer M. | 09/26/2020 |
| The homozygous variant c.245G > A/p.G82D in PNPLA2 is associated with arrhythmogenic cardiomyopathy phenotypic manifestations. | The homozygous variant c.245G > A/p.G82D in PNPLA2 is associated with arrhythmogenic cardiomyopathy phenotypic manifestations.
Rao M, Guo G, Li M, Chen S, Chen K, Chen X, Song J, Hu S. | 09/5/2020 |
| The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. | The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly.
Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T., Free PMC Article | 08/15/2020 |
| PNPLA2 influences TRL secretion, but is not involved in lipid-droplet homeostasis in human hepatoma cells, a physiological role that is quite distinct from the metabolic function of PNPLA2 in nonhepatic tissues. | PNPLA2 influences secretion of triglyceride-rich lipoproteins by human hepatoma cells.
Taxiarchis A, Mahdessian H, Silveira A, Fisher RM, Van't Hooft FM., Free PMC Article | 07/18/2020 |
| Rab18 plays a role upstream of the cytosolic lipolytic enzyme adipose triglyceride lipase (ATGL) and that recruitment of ATGL by Rab18 is mediated by elements of the Arf/GBF1 machinery. We find that Arf4-GFP is accumulated on the subset of lipid droplets associated with Rab18. | Rab18 regulates lipolysis via Arf/GBF1 and adipose triglyceride lipase.
Dejgaard SY, Presley JF. | 07/18/2020 |
| The role of ATGL and its deficiency in lipid and glucose homeostasis in humans and transgenic mice has been discussed. (Review) | The role of adipose triglyceride lipase in lipid and glucose homeostasis: lessons from transgenic mice.
Trites MJ, Clugston RD., Free PMC Article | 05/9/2020 |
| PEDF promotes ubiquitination and proteasomal degradation of ATGL in hepatocytes through COP1.PEDF enhances nuclear import of predominantly cytosolic ATGL protein for its subsequent proteasomal degradation in the nucleus. | PEDF promotes nuclear degradation of ATGL through COP1.
Niyogi S, Ghosh M, Adak M, Chakrabarti P. | 04/11/2020 |