| Expression of TIGAR and its correlation with clinicopathology, prognosis, and 18F-FDG PET/CT parameters in patients with resectable pancreatic ductal adenocarcinoma. | Expression of TIGAR and its correlation with clinicopathology, prognosis, and 18F-FDG PET/CT parameters in patients with resectable pancreatic ductal adenocarcinoma.
Song Y, Wang PY, Zheng Y, Liu C, Wang XM. | 07/26/2024 |
| TIGAR Protects Against Adenine-Induced Ferroptosis in Human Proximal Tubular Epithelial Cells by Activating the mTOR/S6KP70 Axis. | TIGAR Protects Against Adenine-Induced Ferroptosis in Human Proximal Tubular Epithelial Cells by Activating the mTOR/S6KP70 Axis.
Tan QL, Zhang MX, Yao DH, Yan Y, Yang XF, Qin ZH, Gong Y, Meng Q. | 06/23/2023 |
| Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux. | Inhibition of TIGAR Increases Exogenous p53 and Cisplatin Combination Sensitivity in Lung Cancer Cells by Regulating Glycolytic Flux.
Fu J, Yu S, Zhao X, Zhang C, Shen L, Liu Y, Yu H., Free PMC Article | 01/11/2023 |
| TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway. | TIGAR drives colorectal cancer ferroptosis resistance through ROS/AMPK/SCD1 pathway.
Liu MY, Li HM, Wang XY, Xia R, Li X, Ma YJ, Wang M, Zhang HS. | 04/16/2022 |
| The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells. | The Expression of TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Can Be Controlled by the Antioxidant Orchestrator NRF2 in Human Carcinoma Cells.
Simon-Molas H, Sánchez-de-Diego C, Navarro-Sabaté À, Castaño E, Ventura F, Bartrons R, Manzano A., Free PMC Article | 03/12/2022 |
| Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis. | Targeting neuroinflammation to treat cerebral ischemia - The role of TIGAR/NADPH axis.
Li QQ, Li JY, Zhou M, Qin ZH, Sheng R. | 01/29/2022 |
| TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation. | TCF19 and p53 regulate transcription of TIGAR and SCO2 in HCC for mitochondrial energy metabolism and stress adaptation.
Mondal P, Gadad SS, Adhikari S, Ramos EI, Sen S, Prasad P, Das C. | 08/28/2021 |
| Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma. | Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma.
Chu J, Niu X, Chang J, Shao M, Peng L, Xi Y, Lin A, Wang C, Cui Q, Luo Y, Fan W, Chen Y, Sun Y, Guo W, Tan W, Lin D, Wu C., Free PMC Article | 05/1/2021 |
| TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy. | TIGAR impedes compression-induced intervertebral disc degeneration by suppressing nucleus pulposus cell apoptosis and autophagy.
Li Z, Shao Z, Chen S, Huang D, Peng Y, Chen S, Ma K. | 10/24/2020 |
| Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway. | Down-regulation of TFAM increases the sensitivity of tumour cells to radiation via p53/TIGAR signalling pathway.
Jiang X, Wang J., Free PMC Article | 08/13/2020 |
| TIGAR expression is modulated during pancreatic ductal adenocarcinoma development | Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer.
Cheung EC, DeNicola GM, Nixon C, Blyth K, Labuschagne CF, Tuveson DA, Vousden KH., Free PMC Article | 07/25/2020 |
| TIGAR promotes metabolic reprogramming and regulates NSC differentiation through an epigenetic mechanism. | TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation.
Zhou W, Zhao T, Du J, Ji G, Li X, Ji S, Tian W, Wang X, Hao A., Free PMC Article | 06/6/2020 |
| TIGAR protein, is present in SN Lewy bodies of both sporadic PD and DLB. The absence of TIGAR protein in the pathological inclusions of MND or MSA suggests disease specificity and further raises the possibility that TIGAR may be involved in PD pathogenesis. | TIGAR inclusion pathology is specific for Lewy body diseases.
López KLR, Simpson JE, Watson LC, Mortiboys H, Hautbergue GM, Bandmann O, Highley JR. | 05/30/2020 |
| The miR-885-5p and its precursor both can interact mechanically with TIGAR promoter binding site and alter local chromatin structure, and subsequently upregulate TIGAR expression and participate in liver tumorigenesis. | miR-885-5p plays an accomplice role in liver cancer by instigating TIGAR expression via targeting its promoter.
Zou S, Rao Y, Chen W. | 11/16/2019 |
| Study found that downregulation of TIGAR reduced the invasion and metastasis of non-small-cell lung cancer (NSCLC) cells in vitro and in vivo. TIGAR and Met protein expression was positively correlated with late stages of lung cancer. Patients with high co-expression of TIGAR and Met presented a significantly worse survival. In addition, Met signaling pathway is involved in TIGAR-induced invasion and metastasis. | Met is involved in TIGAR-regulated metastasis of non-small-cell lung cancer.
Shen M, Zhao X, Zhao L, Shi L, An S, Huang G, Liu J., Free PMC Article | 08/3/2019 |
| TIGAR knockdown enhanced glioma cell sensitivity to cell hypoxia, irradiation and temozolomide. | Knockdown of the TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) Sensitizes Glioma Cells to Hypoxia, Irradiation and Temozolomide.
Maurer GD, Heller S, Wanka C, Rieger J, Steinbach JP., Free PMC Article | 06/8/2019 |
| Knockdown of TP53 induced glycolysis and apoptosis(TIGAR) was able to radiosensitize thioredoxin reductase-1-overexpressing gliomas by inhibiting irradiation -induced thioredoxin-1 nuclear transport. | TIGAR knockdown radiosensitizes TrxR1-overexpressing glioma in vitro and in vivo via inhibiting Trx1 nuclear transport.
Zhang Y, Chen F, Tai G, Wang J, Shang J, Zhang B, Wang P, Huang B, Du J, Yu J, Zhang H, Liu F., Free PMC Article | 11/3/2018 |
| findings demonstrate that the HTLV-1 latency-maintenance factor p30(II) induces the TP53-induced glycolysis and apoptosis regulator (TIGAR) and counters the oxidative stress, mitochondrial damage, and cytotoxicity caused by the viral oncoproteins Tax and HBZ | The TP53-Induced Glycolysis and Apoptosis Regulator mediates cooperation between HTLV-1 p30(II) and the retroviral oncoproteins Tax and HBZ and is highly expressed in an in vivo xenograft model of HTLV-1-induced lymphoma.
Hutchison T, Malu A, Yapindi L, Bergeson R, Peck K, Romeo M, Harrod C, Pope J, Smitherman L, Gwinn W, Ratner L, Yates C, Harrod R., Free PMC Article | 07/14/2018 |
| simultaneous mutations at all four acetylation sites completely abolish its ability to regulate metabolic targets, such as TIGAR and SLC7A11. Moreover, p53(4KR) is still capable of inducing the p53-Mdm2 feedback loop, but p53-dependent ferroptotic responses are markedly abrogated | Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression.
Wang SJ, Li D, Ou Y, Jiang L, Chen Y, Zhao Y, Gu W., Free PMC Article | 12/2/2017 |
| High TIGAR expression was an independent predictor of poor survival and high incidence of relapse in adult patients with CN-AML. TIGAR also showed high expression in multiple human leukemia cell lines and knockdown of TIGAR activated glycolysis through PFKFB3 upregulation in human leukemia cells. | TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia.
Qian S, Li J, Hong M, Zhu Y, Zhao H, Xie Y, Huang J, Lian Y, Li Y, Wang S, Mao J, Chen Y., Free PMC Article | 11/25/2017 |
| the upregulation of hsamiR101 in ccRCC was induced by hypoxia. Its expression deceased the protein expression of TIGAR and promoted glycolysis. This regulatory pathway may represent a novel mechanism of carcinogenesis and requires further investigation. | Hypoxia-induced hsa-miR-101 promotes glycolysis by targeting TIGAR mRNA in clear cell renal cell carcinoma.
Xu X, Liu C, Bao J. | 07/15/2017 |
| TIGAR expression in breast carcinoma cells promotes metabolic compartmentalization and tumor growth with a mitochondrial metabolic phenotype with lactate and glutamine catabolism. | TP53-inducible Glycolysis and Apoptosis Regulator (TIGAR) Metabolically Reprograms Carcinoma and Stromal Cells in Breast Cancer.
Ko YH, Domingo-Vidal M, Roche M, Lin Z, Whitaker-Menezes D, Seifert E, Capparelli C, Tuluc M, Birbe RC, Tassone P, Curry JM, Navarro-Sabaté À, Manzano A, Bartrons R, Caro J, Martinez-Outschoorn U., Free PMC Article | 06/3/2017 |
| we investigate the crosstalk between PFKFB3 and TIGAR (TP53-Induced Glycolysis and Apoptosis Regulator), a protein known to protect cells from oxidative stress. Our results show consistent TIGAR induction in HeLa cells in response to PFKFB3 knockdown | Akt mediates TIGAR induction in HeLa cells following PFKFB3 inhibition.
Simon-Molas H, Calvo-Vidal MN, Castaño E, Rodríguez-García A, Navarro-Sabaté À, Bartrons R, Manzano A. | 05/6/2017 |
| The study showed that miR-101 inhibited viability, induced apoptosis, pushed glucose metabolism flux from the pentose phosphate pathway into glycolysis in prostate cancer PC3 cell line by decreasing NADPH levels by throughly directly binding to 3'-UTR of TIGAR mRNA and repressing TIGAR expression. | miR-101 Enhances Cisplatin-Induced DNA Damage Through Decreasing Nicotinamide Adenine Dinucleotide Phosphate Levels by Directly Repressing Tp53-Induced Glycolysis and Apoptosis Regulator Expression in Prostate Cancer Cells.
Huang S, Yang Z, Ma Y, Yang Y, Wang S. | 04/15/2017 |
| This study demonstrated that a high p53 expression could be associated with the promotion of glycolysis in gastric cancer via the modulation of TIGAR expression. | Distinctive interrelation of p53 with SCO2, COX, and TIGAR in human gastric cancer.
Kim SH, Choi SI, Won KY, Lim SJ. | 03/25/2017 |