| Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells. | Anoctamin 2-chloride channels reduce simple spike activity and mediate inhibition at elevated calcium concentration in cerebellar Purkinje cells.
Auer F, Franco Taveras E, Klein U, Kesenheimer C, Fleischhauer D, Möhrlen F, Frings S., Free PMC Article | 10/16/2021 |
| a hypothesis where immune reactivity toward EBNA1 through molecular mimicry with ANO2 contributes to the etiopathogenesis of Multiple sclerosis. | Molecular mimicry between Anoctamin 2 and Epstein-Barr virus nuclear antigen 1 associates with multiple sclerosis risk.
Tengvall K, Huang J, Hellström C, Kammer P, Biström M, Ayoglu B, Lima Bomfim I, Stridh P, Butt J, Brenner N, Michel A, Lundberg K, Padyukov L, Lundberg IE, Svenungsson E, Ernberg I, Olafsson S, Dilthey AT, Hillert J, Alfredsson L, Sundström P, Nilsson P, Waterboer T, Olsson T, Kockum I., Free PMC Article | 03/28/2020 |
| residues facing the putative channel pore are responsible both for controlling the ion selectivity and the gating of the channel, providing an initial understanding of molecular mechanism of ion permeation in TMEM16B | Permeation Mechanisms in the TMEM16B Calcium-Activated Chloride Channels.
Pifferi S., Free PMC Article | 08/26/2017 |
| data revealed prominently increased autoantibody reactivity against the chloride-channel protein anoctamin 2 (ANO2) in multiple sclerosis cases compared with controls | Anoctamin 2 identified as an autoimmune target in multiple sclerosis.
Ayoglu B, Mitsios N, Kockum I, Khademi M, Zandian A, Sjöberg R, Forsström B, Bredenberg J, Lima Bomfim I, Holmgren E, Grönlund H, Guerreiro-Cacais AO, Abdelmagid N, Uhlén M, Waterboer T, Alfredsson L, Mulder J, Schwenk JM, Olsson T, Nilsson P., Free PMC Article | 07/30/2016 |
| Olfactory function impairment in Italian patients with type 3 von Willebrand disease with partial deletion of TMEM16B. | Assessment of the olfactory function in Italian patients with type 3 von Willebrand disease caused by a homozygous 253 Kb deletion involving VWF and TMEM16B/ANO2.
Cenedese V, Mezzavilla M, Morgan A, Marino R, Ettorre CP, Margaglione M, Gasparini P, Menini A., Free PMC Article | 10/10/2015 |
| results reveal multidimensional regulation of TMEM16A/16B by preassociated apoCaM and introduce ChIMP as a versatile tool to probe the macromolecular complex and function of Ca(2+)-activated chloride channels | Preassociated apocalmodulin mediates Ca2+-dependent sensitization of activation and inactivation of TMEM16A/16B Ca2+-gated Cl- channels.
Yang T, Hendrickson WA, Colecraft HM., Free PMC Article | 04/18/2015 |
| ANO2 is present in human myometrium. | Calcium-activated chloride channels anoctamin 1 and 2 promote murine uterine smooth muscle contractility.
Bernstein K, Vink JY, Fu XW, Wakita H, Danielsson J, Wapner R, Gallos G., Free PMC Article | 01/31/2015 |
| The third intracellular loop of TMEM16B is the site involved in calcium ion sensitivity, whereas the C-terminal part affects the rate of transition between the open and the closed state of the channel. | TMEM16A-TMEM16B chimaeras to investigate the structure-function relationship of calcium-activated chloride channels.
Scudieri P, Sondo E, Caci E, Ravazzolo R, Galietta LJ. | 08/10/2013 |
| Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) | Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR., Free PMC Article | 06/30/2010 |
| Ano2 likely amplifies the odor-induced generator potential in olfactory sensory neuron cilia by sensing elevated calcium levels, permitting the outward flow of chloride ions from the cell. | ANO2 is the cilial calcium-activated chloride channel that may mediate olfactory amplification.
Stephan AB, Shum EY, Hirsh S, Cygnar KD, Reisert J, Zhao H., Free PMC Article | 07/27/2009 |
| This study suggested that TMEM16B to be a strong candidate for the long sought-after Ca(2+)-dependent chloride channel in the photoreceptor synapse. | TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals.
Stöhr H, Heisig JB, Benz PM, Schöberl S, Milenkovic VM, Strauss O, Aartsen WM, Wijnholds J, Weber BH, Schulz HL., Free PMC Article | 01/21/2010 |
| Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) | Genome-wide association study of panic disorder in the Japanese population.
Otowa T, Yoshida E, Sugaya N, Yasuda S, Nishimura Y, Inoue K, Tochigi M, Umekage T, Miyagawa T, Nishida N, Tokunaga K, Tanii H, Sasaki T, Kaiya H, Okazaki Y. | 02/11/2009 |
| VWF and TMEM16B deletions may have a role in severe von Willebrand disease type 3 | A common 253-kb deletion involving VWF and TMEM16B in German and Italian patients with severe von Willebrand disease type 3.
Schneppenheim R, Castaman G, Federici AB, Kreuz W, Marschalek R, Oldenburg J, Oyen F, Budde U. | 01/21/2010 |
| C12orf3, FLJ10261 (ORAOV2), C11orf25 and FLJ34272 constitute a family of eight-transmembrane proteins with N- and C-terminal tails facing the cytoplasm. | FLJ10261 gene, located within the CCND1-EMS1 locus on human chromosome 11q13, encodes the eight-transmembrane protein homologous to C12orf3, C11orf25 and FLJ34272 gene products.
Katoh M, Katoh M. | 12/2/2003 |