| Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway. | Kinetochore scaffold 1 downregulation suppressed the development of non-small cell lung cancer by inactivating the phosphatidylinositol 3 kinase/protein kinase B (AKT)/nuclear factor-kappa B pathway.
Wu L, Zhang G, Zhu Q, Huang Y. | 04/12/2024 |
| A novel KNL1 intronic splicing variant likely destabilizes the KMN complex, causing primary microcephaly. | A novel KNL1 intronic splicing variant likely destabilizes the KMN complex, causing primary microcephaly.
Fellows BJ, Tolezano GC, Pires SF, Ruegg MSG, Knapp KM, Krepischi ACV, Bicknell LS. | 02/16/2024 |
| LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression. | LINC02418 promotes malignant behaviors in lung adenocarcinoma cells by sponging miR-4677-3p to upregulate KNL1 expression.
Wang T, Zhai R, Lv X, Wang K, Xu J., Free PMC Article | 05/29/2021 |
| CASC5 is a potential tumour driving gene in lung adenocarcinoma. | CASC5 is a potential tumour driving gene in lung adenocarcinoma.
Cui Y, Zhang C, Ma S, Guo W, Cao W, Guan F. | 02/27/2021 |
| [CASC5</I> Gene Expression Changes Correlate with Targeted Mutations in Leukemia]. | [CASC5</I> Gene Expression Changes Correlate with Targeted Mutations in Leukemia].
Bogdanov KV, Merzlikina OV, Mirolyubova YV, Girshova LL, Lomaia EG, Zaritskey AY. | 02/20/2021 |
| KNL1 protein expression was also significantly associated with poorer survival. Moreover, there was a significant correlation between KNL1 and BUB1 in colorectal cancer tissues. KNL1 plays an effective role in decreasing apoptosis and promoting the proliferation of colorectal cancer cells, suggesting that its inhibition may represent a promising therapeutic approach in patients with colorectal cancer. | Effect of KNL1 on the proliferation and apoptosis of colorectal cancer cells.
Bai T, Zhao Y, Liu Y, Cai B, Dong N, Li B., Free PMC Article | 01/11/2020 |
| KNL1 mutation is associated with Microcephaly. | Microcephaly Modeling of Kinetochore Mutation Reveals a Brain-Specific Phenotype.
Omer Javed A, Li Y, Muffat J, Su KC, Cohen MA, Lungjangwa T, Aubourg P, Cheeseman IM, Jaenisch R., Free PMC Article | 12/21/2019 |
| Data show how KNL1 binds both PP1 and microtubules. Unexpectedly, PP1 and microtubules bind KNL1 via overlapping binding sites. Co-sedimentation assays unequivocally demonstrated that microtubules and PP1 binding to KNL1 is mutually exclusive, with preferential formation of the KNL1:PP1 holoenzyme in the presence of PP1. | KNL1 Binding to PP1 and Microtubules Is Mutually Exclusive.
Bajaj R, Bollen M, Peti W, Page R., Free PMC Article | 09/21/2019 |
| Study demonstrates that KNL1 acts as a receptor of linear ubiquitin chains to anchor CENP-E at attached kinetochores. Thus, linear ubiquitin chains constitute a critical mechanism for chromosome congression and alignment by coupling the dynamic kinetochore microtubule motor CENP-E to the static one, the KMN network. | LUBAC controls chromosome alignment by targeting CENP-E to attached kinetochores.
Wu M, Chang Y, Hu H, Mu R, Zhang Y, Qin X, Duan X, Li W, Tu H, Zhang W, Wang G, Han Q, Li A, Zhou T, Iwai K, Zhang X, Li H., Free PMC Article | 02/23/2019 |
| Mutations in the CASC5 gene were found to encode a kinetochore protein essential for mitotic cell division and to cause autosomal recessive primary microcephaly 4. (Review) | D40/KNL1/CASC5 and autosomal recessive primary microcephaly.
Takimoto M. | 09/1/2018 |
| Therefore, Mps1 promotes checkpoint activation through sequentially phosphorylating Knl1, Bub1, and Mad1. This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 and to kinetochore-microtubule attachment. | A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling.
Ji Z, Gao H, Jia L, Li B, Yu H., Free PMC Article | 02/10/2018 |
| CASC5 may contribute to the morphological and structural changes of the human brain during recent evolution. The observed between-population divergence of CASC5 variants was driven by natural selection that tends to favor a larger gray matter volume in East Asians. | Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.
Shi L, Hu E, Wang Z, Liu J, Li J, Li M, Chen H, Yu C, Jiang T, Su B. | 07/29/2017 |
| Involvement of CASC5 in autosomal recessive microcephaly and a founder effect of the c.6125G>A mutation. | Refining the phenotype associated with CASC5 mutation.
Saadi A, Verny F, Siquier-Pernet K, Bole-Feysot C, Nitschke P, Munnich A, Abada-Dendib M, Chaouch M, Abramowicz M, Colleaux L. | 10/22/2016 |
| Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner | Targeted Knockdown of the Kinetochore Protein D40/Knl-1 Inhibits Human Cancer in a p53 Status-Independent Manner.
Urata YN, Takeshita F, Tanaka H, Ochiya T, Takimoto M., Free PMC Article | 08/6/2016 |
| We propose that CASC5 has a key role for the correct functioning of DNA damage response proteins, and a defect in this connection might affect upstream and downstream DNA damage response events as response to increased genotoxic stress. | A novel homozygous splicing mutation of CASC5 causes primary microcephaly in a large Pakistani family.
Szczepanski S, Hussain MS, Sur I, Altmüller J, Thiele H, Abdullah U, Waseem SS, Moawia A, Nürnberg G, Noegel AA, Baig SM, Nürnberg P. | 05/21/2016 |
| Data show sequential multisite regulation of the microtubule-associated protein KNL1-kinase-adaptor complex BUB1/BUB3 interaction. | Sequential multisite phospho-regulation of KNL1-BUB3 interfaces at mitotic kinetochores.
Vleugel M, Omerzu M, Groenewold V, Hadders MA, Lens SMA, Kops GJPL. | 06/20/2015 |
| Mechanisms of mitosis-specific assembly of the checkpoint platform Knl1/MIS12/NDC80 at human kinetochores. | Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
Kim S, Yu H., Free PMC Article | 03/21/2015 |
| PP2A-B56 is a key phosphatase for the removal of the Mps1-mediated Knl1 phosphorylations necessary for Bub1/BubR1 recruitment in mammalian cells. | PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing.
Espert A, Uluocak P, Bastos RN, Mangat D, Graab P, Gruneberg U., Free PMC Article | 11/29/2014 |
| Protein phosphatase 1 (PP1) binding to KNL1 during prometaphase reduces the levels of Bub proteins at kinetochores to approximately the level recruited by four active MELT repeats. | A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation.
Zhang G, Lischetti T, Nilsson J. | 10/11/2014 |
| In cells depleted of endogenous Knl1, kinetochore-targeted Knl1(1-250) suffices to restore spindle assembly checkpoint and chromosome alignment | KI motifs of human Knl1 enhance assembly of comprehensive spindle checkpoint complexes around MELT repeats.
Krenn V, Overlack K, Primorac I, van Gerwen S, Musacchio A. | 08/23/2014 |
| KNL1 is a requirement for Aurora B activity at kinetochores and for wild-type kinetochore-MT attachment dynamics. | KNL1 facilitates phosphorylation of outer kinetochore proteins by promoting Aurora B kinase activity.
Caldas GV, DeLuca KF, DeLuca JG., Free PMC Article | 04/12/2014 |
| KNL1 contains an extensive array of short linear sequence modules that encompass TxxOmega and MELT motifs and that can independently localize BUB1. | Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation.
Vleugel M, Tromer E, Omerzu M, Groenewold V, Nijenhuis W, Snel B, Kops GJ., Free PMC Article | 04/12/2014 |
| Data provide strong evidence for CASC5 as a novel MCPH gene, and underscore the role of kinetochore integrity in proper volumetric development of the human brain. | Kinetochore KMN network gene CASC5 mutated in primary microcephaly.
Genin A, Desir J, Lambert N, Biervliet M, Van Der Aa N, Pierquin G, Killian A, Tosi M, Urbina M, Lefort A, Libert F, Pirson I, Abramowicz M. | 06/1/2013 |
| we identify the Blinkin motif critical for interaction with BUBR1, define the stoichiometry and affinity of the interaction, and present a 2.2 Angstrom resolution crystal structure of the complex | Structure of a Blinkin-BUBR1 complex reveals an interaction crucial for kinetochore-mitotic checkpoint regulation via an unanticipated binding Site.
Bolanos-Garcia VM, Lischetti T, Matak-Vinković D, Cota E, Simpson PJ, Chirgadze DY, Spring DR, Robinson CV, Nilsson J, Blundell TL., Free PMC Article | 03/10/2012 |
| Expression levels of D40 mRNA and proteins decrease according to the degree of spermatogenesis impairment in male infertile patients. | Testis cancer gene D40 expression and its relationship with clinicopathological features in infertile men.
Sasao T, Takimoto M, Itoh N, Maeda T, Tanaka T, Masumori N, Tsukamoto T. | 06/4/2011 |