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    DAZ2 deleted in azoospermia 2 [ Homo sapiens (human) ]

    Gene ID: 57055, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.

    Direct reprogramming of human Sertoli cells into male germline stem cells with the self-renewal and differentiation potentials via overexpressing DAZL/DAZ2/BOULE genes.
    Zhang W, Chen W, Cui Y, Wen L, Yuan Q, Zhou F, Qiu Q, Sun M, Li Z, He Z., Free PMC Article

    03/19/2022
    study reported a new type of AZFc deletion (gr/gr-DAZ2-DAZ4-CDY1b) and hypothesis that this new deletion is the result of 2 successive events favored by the unstable structure of AZFc region; also demonstrated that this deletion constitutes a relative high-risk factor for male infertility in Tunisian population

    gr/gr-DAZ2-DAZ4-CDY1b deletion is a high-risk factor for male infertility in Tunisian population.
    Ghorbel M, Baklouti-Gargouri S, Keskes R, Chakroun N, Sellami A, Fakhfakh F, Ammar-Keskes L.

    04/1/2017
    Studies indicate that partial RNA-binding proteins DAZ1/2 deletion was associated wih male infertility, but partial RNA-binding proteins DAZ3/4 deletion was not associated with male infertility.

    Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility.
    Zhang Y, Li M, Xiao F, Teng R, Zhang C, Lan A, Gu K, Li J, Wang D, Li H, Jiang L, Zeng S, He M, Huang Y, Guo P, Zhang X, Yang X.

    11/28/2015
    There appears to be an asociation of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.

    Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population.
    Li Q, Qiao D, Song NH, Ding Y, Wang ZJ, Yang J, Wang W, Yin CJ.

    10/4/2014
    Deletion of DAZ2 and DAZ4 gene copies is associated with male infertility.

    Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men.
    Ghorbel M, Baklouti-Gargouri S, Keskes R, Chakroun N, Sellami A, Fakhfakh F, Ammar-Keskes L.

    09/27/2014
    All four DAZ genes are expressed in the human testis, and their products are highly polymorphic among men

    Polymorphic expression of DAZ proteins in the human testis.
    Kim B, Lee Y, Kim Y, Lee KH, Chun S, Rhee K, Seo JT, Kim SW, Paick JS.

    01/21/2010
    Observational study of genotype prevalence and gene-disease association. (HuGE Navigator)

    A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians.
    Zhang F, Li Z, Wen B, Jiang J, Shao M, Zhao Y, He Y, Song X, Qian J, Lu D, Jin L.

    03/18/2009
    AZFc subdeletions do not seem to cause severe impairment of spermatogenesis in Chilean men.

    AZFc partial deletions in Chilean men with severe spermatogenic failure.
    Lardone MC, Parodi DA, Ebensperger M, PeƱaloza P, Cornejo V, Valdevenito R, Pommer R, Castro A.

    01/21/2010
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles03/13/2008
    Observational study of genotype prevalence. (HuGE Navigator)

    DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men.
    Yang Y, Xiao CY, A ZC, Zhang SZ, Li X, Zhang SX.

    03/13/2008
    DAZ gene copy number in severely idiopathic infertile men. Gene deletion of two copies of DAZ (DAZI and 2) was the cause of spermatogenic damage.

    A novel approach for the analysis of DAZ gene copy number in severely idiopathic infertile men.
    Ferlin A, Moro E, Rossi A, Foresta C.

    01/21/2010
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