| Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia. | Cyclooxygenase-2 activates EGFR-ERK1/2 pathway via PGE2-mediated ADAM-17 signaling in testosterone-induced benign prostatic hyperplasia.
Abo-El Fetoh ME, Abdel-Fattah MM, Mohamed WR, Ramadan LAA, Afify H., Free PMC Article | 03/1/2023 |
| Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice. | Cardiomyocyte-specific knockout of ADAM17 ameliorates left ventricular remodeling and function in diabetic cardiomyopathy of mice.
Xue F, Cheng J, Liu Y, Cheng C, Zhang M, Sui W, Chen W, Hao P, Zhang Y, Zhang C., Free PMC Article | 08/6/2022 |
| MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression. | MiR-708-3p Alleviates Inflammation and Myocardial Injury After Myocardial Infarction by Suppressing ADAM17 Expression.
Qu Y, Zhang J, Zhang J, Xiao W. | 12/11/2021 |
| Influences of miR-708 on cerebral ischemia-reperfusion injury through targeted regulation of ADAM17. | Influences of miR-708 on cerebral ischemia-reperfusion injury through targeted regulation of ADAM17.
Gao J, Sun CH, Zhu YF, Tian HT, Liang HY, Zhang DP. | 07/3/2021 |
| Effect of miR-26a-5p targeting ADAM17 gene on apoptosis, inflammatory factors and oxidative stress response of myocardial cells in hypoxic model. | Effect of miR-26a-5p targeting ADAM17 gene on apoptosis, inflammatory factors and oxidative stress response of myocardial cells in hypoxic model.
Wen X, Yin Y, Li X, He T, Wang P, Song M, Gao J. | 05/29/2021 |
| Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease. | Pulmonary, cardiac and renal distribution of ACE2, furin, TMPRSS2 and ADAM17 in rats with heart failure: Potential implication for COVID-19 disease.
Khoury EE, Knaney Y, Fokra A, Kinaneh S, Azzam Z, Heyman SN, Abassi Z., Free PMC Article | 05/15/2021 |
| The inhibition of Nox4-ROS-ADAM17 pathway and over-activation of ERK1/2 might be associated with the beneficial role of rutaecarpine in hypertensive cardiac hypertrophy, thus providing additional evidence for preventing hypertensive cardiac hypertrophy with rutaecarpine. | Rutaecarpine prevents hypertensive cardiac hypertrophy involving the inhibition of Nox4-ROS-ADAM17 pathway.
Zeng SY, Yang L, Lu HQ, Yan QJ, Gao L, Qin XP., Free PMC Article | 07/11/2020 |
| Nox1/4 dual inhibitor GKT137831 protects against hypertensive cardiac remodelling in AAC-induced hypertensive rats, and the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways. | Nox1/4 dual inhibitor GKT137831 attenuates hypertensive cardiac remodelling associating with the inhibition of ADAM17-dependent proinflammatory cytokines-induced signalling pathways in the rats with abdominal artery constriction.
Zeng SY, Yang L, Yan QJ, Gao L, Lu HQ, Yan PK. | 03/30/2019 |
| CGRP has an anti-inflammatory effect in vascular smooth muscle cells (VSMCs) stimulated by Ang II; ADAM17 is involved in the protective effect of CGRP against Ang II-induced inflammation via the EGFR-ERK1/2 pathway in VSMCs | Evidence That ADAM17 Mediates the Protective Action of CGRP against Angiotensin II-Induced Inflammation in Vascular Smooth Muscle Cells.
Zeng SY, Yang L, Hong CL, Lu HQ, Yan QJ, Chen Y, Qin XP., Free PMC Article | 12/29/2018 |
| Enhanced ADAM17 expression, along with decreased TIMP-3 and increased TNF-alpha expression, especially within one week after acute myocardial infarction | Enhanced ADAM17 expression is associated with cardiac remodeling in rats with acute myocardial infarction.
Zheng DY, Zhao J, Yang JM, Wang M, Zhang XT. | 02/4/2017 |
| high glucose-induced HIF-1alpha activation and ADAM17 up-regulation. | High Glucose Up-regulates ADAM17 through HIF-1α in Mesangial Cells.
Li R, Uttarwar L, Gao B, Charbonneau M, Shi Y, Chan JS, Dubois CM, Krepinsky JC., Free PMC Article | 11/21/2015 |
| Angiotensin II induces ADAM17 expression in the vasculatures through a hypoxia inducible factor 1alpha-dependent transcriptional upregulation, potentially contributing to end-organ damage in the cardiovascular system. | Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1α.
Obama T, Takayanagi T, Kobayashi T, Bourne AM, Elliott KJ, Charbonneau M, Dubois CM, Eguchi S., Free PMC Article | 07/25/2015 |
| We conclude that adenosine-stimulated exocytosis requires PKC- and ADAM17-dependent EGFR transactivation and that the function of ADAM17 in this pathway depends on the phosphorylation state of Ser-811 in its cytoplasmic domain. | A1 adenosine receptor-stimulated exocytosis in bladder umbrella cells requires phosphorylation of ADAM17 Ser-811 and EGF receptor transactivation.
Prakasam HS, Gallo LI, Li H, Ruiz WG, Hallows KR, Apodaca G., Free PMC Article | 07/25/2015 |
| ADAM17 mRNA expression is observed in the acute phase of wound healing in dermis for 15 days. | Gene expression and in situ localization of ADAM17 during skin wound healing.
Kawaguchi M, Suzuki T. | 01/3/2015 |
| TGF-beta stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19 | Canonical transforming growth factor-β signaling regulates disintegrin metalloprotease expression in experimental renal fibrosis via miR-29.
Ramdas V, McBride M, Denby L, Baker AH., Free PMC Article | 07/5/2014 |
| Our results provide new understanding of the role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in FKN expression and shedding. | Role of ADAM-17, p38 MAPK, cathepsins, and the proteasome pathway in the synthesis and shedding of fractalkine/CX₃ CL1 in rheumatoid arthritis.
Jones BA, Riegsecker S, Rahman A, Beamer M, Aboualaiwi W, Khuder SA, Ahmed S. | 01/4/2014 |
| Nox4 is required in Ang II-induced EGFR activation and subsequent cardiac hypertrophy; it increased the expression of ADAM17, which induced the release of mature HB-EGF. ROS were also required in the Nox4-mediated upregulation of ADAM17 expression. | Upregulation of Nox4 promotes angiotensin II-induced epidermal growth factor receptor activation and subsequent cardiac hypertrophy by increasing ADAM17 expression.
Zeng SY, Chen X, Chen SR, Li Q, Wang YH, Zou J, Cao WW, Luo JN, Gao H, Liu PQ. | 11/30/2013 |
| beta1 integrin has an important physiological role in ADAM17 activity regulation. | A disintegrin and metalloenzyme (ADAM) 17 activation is regulated by α5β1 integrin in kidney mesangial cells.
Gooz P, Dang Y, Higashiyama S, Twal WO, Haycraft CJ, Gooz M., Free PMC Article | 08/4/2012 |
| these results provide evidence for a pro-survival neuroprotective role of ADAM17 and its engagement in the process of preconditioning-induced hypoxic tolerance | Differential expression of ADAM15 and ADAM17 metalloproteases in the rat brain after severe hypobaric hypoxia and hypoxic preconditioning.
Rybnikova E, Gluschenko T, Galeeva A, Tulkova E, Nalivaeva NN, Makova NZ, Turner AJ, Samoilov M. | 06/30/2012 |
| TACE may play a role in modulating repulsive guidance molecule (RGM)-induced repulsive behavior of neurons by regulating neogenin expression on the cell surface. | TACE cleaves neogenin to desensitize cortical neurons to the repulsive guidance molecule.
Okamura Y, Kohmura E, Yamashita T. | 05/26/2012 |
| These results strongly suggest that TACE/ADAM17 participates in in vivo apoptosis of male germ cells induced by DNA damage. | Involvement of TACE/ADAM17 and ADAM10 in etoposide-induced apoptosis of germ cells in rat spermatogenesis.
Lizama C, Rojas-Benitez D, Antonelli M, Ludwig A, Moreno RD. | 02/4/2012 |
| These studies identify a novel signaling circuit in which Trk activates ADAM17-dependent p75NTR production to feedback to sustain Trk signaling and Trk-dependent survival. | Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling.
Kommaddi RP, Thomas R, Ceni C, Daigneault K, Barker PA. | 08/20/2011 |
| ADAM17 activation is involved in epidermal growth factor receptor activation and subsequent neointimal hyperplasia after vascular injury. | A disintegrin and metalloprotease 17 mediates neointimal hyperplasia in vasculature.
Takaguri A, Kimura K, Hinoki A, Bourne AM, Autieri MV, Eguchi S., Free PMC Article | 07/9/2011 |
| ADAM17 is one of the elements triggering physiological germ cell apoptosis during the first wave of spermaatogenesis. | TACE/ADAM17 is involved in germ cell apoptosis during rat spermatogenesis.
Lizama C, Rojas-Benítez D, Antonelli M, Ludwig A, Bustamante-Marín X, Brouwer-Visser J, Moreno RD. | 12/4/2010 |
| analysis of vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality [review] | Vitamin D inhibition of TACE and prevention of renal osteodystrophy and cardiovascular mortality.
Dusso A, Arcidiacono MV, Yang J, Tokumoto M., Free PMC Article | 09/27/2010 |