| RNA helicase DHX33 regulates HMGB family genes in human cancer cells. | RNA helicase DHX33 regulates HMGB family genes in human cancer cells.
Wang X, Chen S, Wen F, Zeng Y, Zhang Y. | 09/1/2023 |
| Systematic analysis of the prognostic and immunological role of DHX33 in pan-cancer. | Systematic analysis of the prognostic and immunological role of DHX33 in pan-cancer.
Ding J, Zhou J, Shen X, Zhang M, Feng X, Xu Z. | 07/10/2023 |
| Comprehensive analysis of immune implication and prognostic value of DHX33 in sarcoma. | Comprehensive analysis of immune implication and prognostic value of DHX33 in sarcoma.
Zhang X, Shao Y, Zhou Y, Zhu Z, Wang X., Free PMC Article | 05/3/2023 |
| GSK-3beta phosphorylation of DHX33 leads to its ubiquitination mediated protein degradation. | GSK-3β phosphorylation of DHX33 leads to its ubiquitination mediated protein degradation.
Zhang Y, Chen S, Peng C. | 12/10/2022 |
| Long non-coding RNA HOTAIR promotes hepatocellular carcinoma progression by regulating miR-526b-3p/DHX33 axis. | Long non-coding RNA HOTAIR promotes hepatocellular carcinoma progression by regulating miR-526b-3p/DHX33 axis.
Liu Z, Ouyang G, Lu W, Zhang H. | 02/26/2022 |
| Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes. | Function of DHX33 in promoting Warburg effect via regulation of glycolytic genes.
Peng C, Hou ST, Deng CX, Zhang Y. | 09/11/2021 |
| DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription. | DHX33 Recruits Gadd45a To Cause DNA Demethylation and Regulates a Subset of Gene Transcription.
Feng W, Chen S, Wang J, Wang X, Chen H, Ning W, Zhang Y., Free PMC Article | 08/22/2020 |
| This study highlights that DHX33 protein is critical in glioblastoma cell proliferation and its potential as a novel therapeutic drug target. | The RNA helicase DHX33 is required for cancer cell proliferation in human glioblastoma and confers resistance to PI3K/mTOR inhibition.
Wang H, Yu J, Wang X, Zhang Y. | 04/11/2020 |
| DHX33 is highly expressed in human colon cancers. DHX33 and Wnt/beta-catenin reciprocally regulate each other. | DHX33 promotes colon cancer development downstream of Wnt signaling.
Zhu Y, Du Y, Zhang Y. | 03/14/2020 |
| Results reveal that DHX33 represses apoptosis through the direct upregulation of Bcl-2 gene transcription. AP-2beta is a binding partner for DHX33 and that DHX33 acts as a coactivator for AP-2beta to promote the transcription of antiapoptotic Bcl-2 gene. | DHX33 Interacts with AP-2β To Regulate Bcl-2 Gene Expression and Promote Cancer Cell Survival.
Wang J, Feng W, Yuan Z, Weber JD, Zhang Y., Free PMC Article | 02/5/2020 |
| DHX33 doublet is due to alternative translation initiation by two in-frame initiation codons. DHX33 translation initiation from either AUG codon happens at equal efficiency. Short DHX33 protein has similar cellular location and functions with full-length DHX33. Leaky scanning normally occurs in DHX33 mRNA translation, which may serve as a safeguard mechanism to ensure optimal DHX33 translation efficiency. | Alternative translation initiation from two in-frame start codons in DHX33 gene.
Wang J, Yuan Z, Zhang Y. | 11/10/2018 |
| In clinical samples, the expression of Rab1A or DHX33 was reversely correlated with miR-634. Re-expression of Rab1A or DHX33 abrogated the miR-634-mediated inhibition of cell proliferation and migration. Collectively, our data suggest a tumor suppressor role of miR-634 in hepatocellular carcinoma. | miR-634 exhibits anti-tumor activities toward hepatocellular carcinoma via Rab1A and DHX33.
Zhang CZ, Cao Y, Fu J, Yun JP, Zhang MF., Free PMC Article | 09/30/2017 |
| High expression of DHX33 is associated with non-Hodgkin's lymphoma and acute myeloid leukemia. | Role of DHX33 in c-Myc-induced cancers.
Fu J, Liu Y, Wang X, Yuan B, Zhang Y. | 09/9/2017 |
| Study demonstrates that DHX33 acts as a direct transcriptional regulator to promote cell cycle progression and plays an important role in driving cell proliferation during both embryo development and tumorigenesis. | DHX33 Transcriptionally Controls Genes Involved in the Cell Cycle.
Yuan B, Wang X, Fan C, You J, Liu Y, Weber JD, Zhong H, Zhang Y., Free PMC Article | 06/24/2017 |
| Our data therefore suggest DHX33 is overexpressed in HCC and serves as a promising prognostic biomarker for this deadly disease. | DHX33 expression is increased in hepatocellular carcinoma and indicates poor prognosis.
Tian QH, Zhang MF, Luo RG, Fu J, He C, Hu G, Zeng JS. | 05/7/2017 |
| The results reveal a newly recognized function of DHX33 in mRNA translation initiation, further solidifying its central role in promoting cell growth and proliferation. | The DHX33 RNA Helicase Promotes mRNA Translation Initiation.
Zhang Y, You J, Wang X, Weber J., Free PMC Article | 10/31/2015 |
| Data indicate that DHX33 forms the inflammasome complex with NLRP3 following stimulation with cytosolic RNA. | The DHX33 RNA helicase senses cytosolic RNA and activates the NLRP3 inflammasome.
Mitoma H, Hanabuchi S, Kim T, Bao M, Zhang Z, Sugimoto N, Liu YJ., Free PMC Article | 11/2/2013 |
| results directly implicate DHX33 as a crucial player in establishing rRNA synthesis rates in the face of Ras(V12) or ARF signals, adjusting ribosome biogenesis to match the appropriate growth or antigrowth signals. | P19ARF and RasV¹² offer opposing regulation of DHX33 translation to dictate tumor cell fate.
Zhang Y, Saporita AJ, Weber JD., Free PMC Article | 06/15/2013 |
| we show the mechanistic importance of DHX33 in rRNA transcription and proliferation | Identification of DHX33 as a mediator of rRNA synthesis and cell growth.
Zhang Y, Forys JT, Miceli AP, Gwinn AS, Weber JD., Free PMC Article | 12/31/2011 |
| Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) | Polymorphisms in innate immunity genes and risk of childhood leukemia.
Han S, Lan Q, Park AK, Lee KM, Park SK, Ahn HS, Shin HY, Kang HJ, Koo HH, Seo JJ, Choi JE, Ahn YO, Chanock SJ, Kim H, Rothman N, Kang D., Free PMC Article | 06/30/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesRisk of meningioma and common variation in genes related to innate immunity.
Rajaraman P, Brenner AV, Neta G, Pfeiffer R, Wang SS, Yeager M, Thomas G, Fine HA, Linet MS, Rothman N, Chanock SJ, Inskip PD. Common variation in genes related to innate immunity and risk of adult glioma.
Rajaraman P, Brenner AV, Butler MA, Wang SS, Pfeiffer RM, Ruder AM, Linet MS, Yeager M, Wang Z, Orr N, Fine HA, Kwon D, Thomas G, Rothman N, Inskip PD, Chanock SJ. | 06/30/2010 |