| alpha-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells. | α-Kleisin subunit of cohesin preserves the genome integrity of embryonic stem cells.
Yoon S, Choi EH, Park SJ, Kim KP., Free PMC Article | 02/28/2023 |
| MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage. | MicroRNA-202 safeguards meiotic progression by preventing premature SEPARASE-mediated REC8 cleavage.
Chen J, Gao C, Luo M, Zheng C, Lin X, Ning Y, Ma L, He W, Xie D, Liu K, Hong K, Han C., Free PMC Article | 08/13/2022 |
| Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes. | Meiotic genes in premature ovarian insufficiency: variants in HROB and REC8 as likely genetic causes.
Tucker EJ, Bell KM, Robevska G, van den Bergen J, Ayers KL, Listyasari N, Faradz SM, Dulon J, Bakhshalizadeh S, Sreenivasan R, Nouyou B, Carre W, Akloul L, Duros S, Domin-Bernhard M, Belaud-Rotureau MA, Touraine P, Jaillard S, Sinclair AH., Free PMC Article | 04/9/2022 |
| EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8. | EWSR1 affects PRDM9-dependent histone 3 methylation and provides a link between recombination hotspots and the chromosome axis protein REC8.
Tian H, Billings T, Petkov PM., Free PMC Article | 08/14/2021 |
| Our genetic analysis demonstrates that cohesins containing STAG3 and REC8 are the main complex required for centromeric cohesion, and RAD21L cohesins are required for normal clustering of pericentromeric heterochromatin. Furthermore, the STAG3/REC8 and STAG3/RAD21L cohesins are the primary cohesins required for axis formation. | Genetic Interactions Between the Meiosis-Specific Cohesin Components, STAG3, REC8, and RAD21L.
Ward A, Hopkins J, Mckay M, Murray S, Jordan PW., Free PMC Article | 11/18/2017 |
| REC8-containing cohesin complexes provide canonical SCC, not RAD21 or RAD21L, at the prophase stage of meiosis I in spermatocytes. | High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation.
Agostinho A, Manneberg O, van Schendel R, Hernández-Hernández A, Kouznetsova A, Blom H, Brismar H, Höög C., Free PMC Article | 08/19/2017 |
| To decipher the functions of the two meiosis-specific kleisins, REC8 or RAD21L, together with the only meiosis-specific SMC protein SMC1b, we generated Smc1b-/-Rec8-/- and Smc1b-/-Rad21L-/- mouse mutants. | Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis.
Biswas U, Hempel K, Llano E, Pendas A, Jessberger R., Free PMC Article | 04/29/2017 |
| Rec8 establishes cohesion when activated during DNA replication in fetal oocytes using tamoxifen-inducible Cre. In contrast, no new cohesion is detected when Rec8 is activated in arrested oocytes by tamoxifen despite cohesin synthesis. | Chromosome Cohesion Established by Rec8-Cohesin in Fetal Oocytes Is Maintained without Detectable Turnover in Oocytes Arrested for Months in Mice.
Burkhardt S, Borsos M, Szydlowska A, Godwin J, Williams SA, Cohen PE, Hirota T, Saitou M, Tachibana-Konwalski K., Free PMC Article | 01/14/2017 |
| Plk1 activity is required for meiotic spindle assembly and REC8 cleavage, with pPlk1Ser137 being the action executor, in mouse oocytes during meiotic division. | Unique subcellular distribution of phosphorylated Plk1 (Ser137 and Thr210) in mouse oocytes during meiotic division and pPlk1(Ser137) involvement in spindle formation and REC8 cleavage.
Du J, Cao Y, Wang Q, Zhang N, Liu X, Chen D, Liu X, Xu Q, Ma W., Free PMC Article | 09/17/2016 |
| effects ofAte1ablation are inferred to be caused, at least in part, by the failure to destroy the C-terminal fragment of Rec8 in the absence of N-terminal arginylation. | Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.
Liu YJ, Liu C, Chang Z, Wadas B, Brower CS, Song ZH, Xu ZL, Shang YL, Liu WX, Wang LN, Dong W, Varshavsky A, Hu RG, Li W., Free PMC Article | 08/20/2016 |
| Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 pathway, and open avenues to investigate early meiosis through analysis of Rec8 induction and function | Retinoic acid activates two pathways required for meiosis in mice.
Koubova J, Hu YC, Bhattacharyya T, Soh YQ, Gill ME, Goodheart ML, Hogarth CA, Griswold MD, Page DC., Free PMC Article | 11/7/2015 |
| STAG3-REC8 cohesin complexes have a critical role in supporting meiotic chromosome structure and functions. | STAG3-mediated stabilization of REC8 cohesin complexes promotes chromosome synapsis during meiosis.
Fukuda T, Fukuda N, Agostinho A, Hernández-Hernández A, Kouznetsova A, Höög C., Free PMC Article | 08/9/2014 |
| Findings indicate that cohesin-mediated long-range interactions facilitate discrete gene expression states within preexisting chromosomal compartments. | Cohesin-based chromatin interactions enable regulated gene expression within preexisting architectural compartments.
Seitan VC, Faure AJ, Zhan Y, McCord RP, Lajoie BR, Ing-Simmons E, Lenhard B, Giorgetti L, Heard E, Fisher AG, Flicek P, Dekker J, Merkenschlager M., Free PMC Article | 07/12/2014 |
| Data show that nociceptin induces Rec8 phosphorylation, triggering chromosome dynamics, in spermatocytes during meiosis in postnatal testes. | Nociceptin induces Rec8 phosphorylation and meiosis in postnatal murine testes.
Eto K, Shiotsuki M, Abe S. | 11/2/2013 |
| We report here evidence from the mouse that partial loss of gene function for either Smc1b or Rec8 causes perturbations in the formation of the synaptonemal complex (SC) and affects both synapsis and recombination between homologs during meiotic prophase | Altered cohesin gene dosage affects Mammalian meiotic chromosome structure and behavior.
Murdoch B, Owen N, Stevense M, Smith H, Nagaoka S, Hassold T, McKay M, Xu H, Fu J, Revenkova E, Jessberger R, Hunt P., Free PMC Article | 06/15/2013 |
| show that spermatocytes from mice lacking the two meiosis-specific cohesin subunits RAD21L and REC8 were unable to initiate RAD51- but not DMC1-mediated double-strand break repair | Meiotic cohesin complexes are essential for the formation of the axial element in mice.
Llano E, Herrán Y, García-Tuñón I, Gutiérrez-Caballero C, de Álava E, Barbero JL, Schimenti J, de Rooij DG, Sánchez-Martín M, Pendás AM., Free PMC Article | 09/1/2012 |
| Separase is regulated by two independent mechanisms in meiosis I, binding to securin and inhibitory phosphorylation by CDK1; both must be disrupted to have any effect on either chromosome-associated REC8 levels or premature chromosome separation. | Age-dependent susceptibility of chromosome cohesion to premature separase activation in mouse oocytes.
Chiang T, Schultz RM, Lampson MA., Free PMC Article | 04/14/2012 |
| Rec8 cleavage triggers chiasmata resolution during meiosis I and sister centromere disjunction during meiosis II | Rec8-containing cohesin maintains bivalents without turnover during the growing phase of mouse oocytes.
Tachibana-Konwalski K, Godwin J, van der Weyden L, Champion L, Kudo NR, Adams DJ, Nasmyth K., Free PMC Article | 12/4/2010 |
| the Suv39h-HP1 pathway is not essential for enrichment and mitotic protection of cohesin at centromeres in mammalian cells | The Suv39h-HP1 histone methylation pathway is dispensable for enrichment and protection of cohesin at centromeres in mammalian cells.
Koch B, Kueng S, Ruckenbauer C, Wendt KS, Peters JM. | 01/21/2010 |
| results suggest that the proteolysis of securin is dependent on ubiquitin-proteasome pathway and is necessary for the degradation of Rec8 during meiotic metaphase-to-anaphase transitions in oocytes | Degradation of securin in mouse and pig oocytes is dependent on ubiquitin-proteasome pathway and is required for proteolysis of the cohesion subunit, Rec8, at the metaphase-to-anaphase transition.
Huo LJ, Zhong ZS, Liang CG, Wang Q, Yin S, Ai JS, Yu LZ, Chen DY, Schatten H, Sun QY. | 01/21/2010 |
| loss of armRec8 (homolog separation) and cytokinesis are suppressed until anaphase I by Securin | Loss of Rec8 from chromosome arm and centromere region is required for homologous chromosome separation and sister chromatid separation, respectively, in mammalian meiosis.
Lee J, Okada K, Ogushi S, Miyano T, Miyake M, Yamashita M. | 01/21/2010 |
| Proteolytic activity of separase is therefore essential for Rec8's removal from chromosome arms and for chiasma resolution but not for PBE. | Resolution of chiasmata in oocytes requires separase-mediated proteolysis.
Kudo NR, Wassmann K, Anger M, Schuh M, Wirth KG, Xu H, Helmhart W, Kudo H, McKay M, Maro B, Ellenberg J, de Boer P, Nasmyth K. | 01/21/2010 |
| a major role for REC8 in mammalian meiosis is to limit synapsis to between homologous chromosomes. | Absence of mouse REC8 cohesin promotes synapsis of sister chromatids in meiosis.
Xu H, Beasley MD, Warren WD, van der Horst GT, McKay MJ. | 01/21/2010 |
| Rec8 protein, in association with SMC3 and SMC1beta but not SMC1alpha, is involved in meiosis-specific chromosome behavior; homologous chromosome separation is triggered by selective loss of Rec8 from chromosome arms in meiosis I. | Temporally and spatially selective loss of Rec8 protein from meiotic chromosomes during mammalian meiosis.
Lee J, Iwai T, Yokota T, Yamashita M. | 01/21/2010 |
| Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice. | Analyses of mRNA expression patterns of cohesin subunits Rad21 and Rec8 in mice: germ cell-specific expression of rec8 mRNA in both male and female mice.
Lee J, Yokota T, Yamashita M. | 01/21/2010 |