| Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma. | Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma.
Liu Y, Liu J, Liu C, Jin J, Liu Y. | 02/23/2024 |
| Overexpression of BCCIP predicts an unfavorable prognosis and promotes the proliferation and migration of lung adenocarcinoma. | Overexpression of BCCIP predicts an unfavorable prognosis and promotes the proliferation and migration of lung adenocarcinoma.
Shi J, Lv X, Li W, Ming Z, Zeng L, Yuan J, Chen Y, Liu B, Yang S., Free PMC Article | 01/29/2022 |
| Structure of human BCCIP and implications for binding and modification of partner proteins. | Structure of human BCCIP and implications for binding and modification of partner proteins.
Choi WS, Liu B, Shen Z, Yang W., Free PMC Article | 08/28/2021 |
| BCCIPbeta facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma. | BCCIPβ facilitates p53 ubiquitination via binding with E6 protein in high-risk HPV positive head and neck squamous cell carcinoma.
Wang F, Wang J, Wang J, Zhang L, Fu H, Li J, Tian T, Zuo J, Lv W, Ma X. | 02/13/2021 |
| BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis. | BCCIP is required for nucleolar recruitment of eIF6 and 12S pre-rRNA production during 60S ribosome biogenesis.
Ye C, Liu B, Lu H, Liu J, Rabson AB, Jacinto E, Pestov DG, Shen Z., Free PMC Article | 01/16/2021 |
| BCCIP stabilized YY1 protein in colorectal cancer cells.Transcriptional regulation of BCCIP was associated with its ability to stabilize YY1.BCCIP promoter region contains YY1 binding site (CCGCCATC).BCCIP binds to and activates its promoter in a YY1-dependent fashion. | BCCIP binds to and activates its promoter in a YY1-dependent fashion in HCT116 cells.
Sui Y, Li F, Wu T, Ding J, Lu Z, Wang L, Yang Y, Wang F, Zhao L, Zhu H, Wei T, Jin J, Cai Y. | 06/15/2019 |
| We analyzed the BCCIP protein level in 470 cases of human breast cancer to determine the associations between BCCIP and 53BP1, p53, and subtypes of breast cancer. We further constructed a unique BCCIP knockdown mouse model to determine whether a partial BCCIP deficiency leads to spontaneous breast cancer formation | Roles of BCCIP deficiency in mammary tumorigenesis.
Droz-Rosario R, Lu H, Liu J, Liu NA, Ganesan S, Xia B, Haffty BG, Shen Z., Free PMC Article | 06/9/2018 |
| BCCIPbeta, as a S7 modulator, contributes to the regulation of ribosomal and extraribosomal functions of S7 and has implications in cell growth and tumor development. | BCCIPβ modulates the ribosomal and extraribosomal function of S7 through a direct interaction.
Ba Q, Li X, Huang C, Li J, Fu Y, Chen P, Duan J, Hao M, Zhang Y, Li J, Sun C, Ying H, Song H, Zhang R, Shen Z, Wang H., Free PMC Article | 04/7/2018 |
| this study identifies BCCIP as a novel factor critical for microtubule regulation and explicates a mechanism utilized by BCCIP in tumor suppression. | Regulation of spindle integrity and mitotic fidelity by BCCIP.
Huhn SC, Liu J, Ye C, Lu H, Jiang X, Feng X, Ganesan S, White E, Shen Z., Free PMC Article | 10/14/2017 |
| Expression of BCCIP beta was notably higher in tumor tissues of esophageal squamous cell carcinoma (ESCC) and Eca 109 cells. In vitro studies such as starvation and refeeding assay along with BCCIP beta-shRNA transfection assay demonstrated that BCCIP beta expression promoted proliferation of ESCC cells. | High Expression of BCCIP β Can Promote Proliferation of Esophageal Squamous Cell Carcinoma.
Chen L, Ni S, Li M, Shen C, Lin Z, Ouyang Y, Xia F, Liang L, Jiang W, Ni R, Zhang J. | 07/15/2017 |
| we demonstrate that BCCIPbeta induces a conformational change within the RAD51 filament that promotes release of ADP to help maintain an active presynaptic filament. Our findings reveal a functional role for BCCIPbeta as a RAD51 accessory factor in HR. | The β-isoform of BCCIP promotes ADP release from the RAD51 presynaptic filament and enhances homologous DNA pairing.
Kelso AA, Goodson SD, Watts LE, Ledford LL, Waldvogel SM, Diehl JN, Shah SB, Say AF, White JD, Sehorn MG., Free PMC Article | 06/10/2017 |
| the existence of both INO80 and YY1 is required for recruiting the INO80/YY1 complex to BCCIP promoter region. Our findings strongly indicate that BCCIP is a potential target gene of the INO80/YY1 complex. | Human INO80/YY1 chromatin remodeling complex transcriptionally regulates the BRCA2- and CDKN1A-interacting protein (BCCIP) in cells.
Su J, Sui Y, Ding J, Li F, Shen S, Yang Y, Lu Z, Wang F, Cao L, Liu X, Jin J, Cai Y., Free PMC Article | 06/10/2017 |
| The BCCIPbeta, but not BCCIPalpha, interacts with EIF6 and RPL23/UL14 and stabilizes the latter. | The beta-isoform of the BRCA2 and CDKN1A(p21)-interacting protein (BCCIP) stabilizes nuclear RPL23/uL14.
Wyler E, Wandrey F, Badertscher L, Montellese C, Alper D, Kutay U. | 01/27/2016 |
| Results indicate that BCCIP germ line mutations are unlikely to be a major contributor to familial breast/ovarian cancer risk in our population. | Mutation analysis of the BCCIP gene for breast cancer susceptibility in breast/ovarian cancer families.
Bonache S, Gutierrez-Enriquez S, Tenés A, Masas M, Balmaña J, Diez O. | 01/11/2014 |
| regulation of p21 intracellular distribution is a new mechanism for BCCIP to modulate p21 functions | BCCIP is required for the nuclear localization of the p21 protein.
Fan J, Wray J, Meng X, Shen Z., Free PMC Article | 01/21/2010 |
| BCCIP protein expression was not detectable in approximately 45% of all astrocytic tumors. | Alterations of BCCIP, a BRCA2 interacting protein, in astrocytomas.
Liu J, Lu H, Ohgaki H, Merlo A, Shen Z., Free PMC Article | 01/21/2010 |
| BCCIP is phosphorylated by the Src tyrosine kinase and dephosphorylated by the PTPmu tyrosine phosphatase; neurite outgrowth assays suggest that BCCIP and PTPmu are in a common signal transduction pathway. | BCCIP associates with the receptor protein tyrosine phosphatase PTPmu.
Phillips-Mason PJ, Mourton T, Major DL, Brady-Kalnay SM., Free PMC Article | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (3) articlesPredisposition for TMPRSS2-ERG fusion in prostate cancer by variants in DNA repair genes.
Luedeke M, Linnert CM, Hofer MD, Surowy HM, Rinckleb AE, Hoegel J, Kuefer R, Rubin MA, Vogel W, Maier C. New common variants affecting susceptibility to basal cell carcinoma.
Stacey SN, Sulem P, Masson G, Gudjonsson SA, Thorleifsson G, Jakobsdottir M, Sigurdsson A, Gudbjartsson DF, Sigurgeirsson B, Benediktsdottir KR, Thorisdottir K, Ragnarsson R, Scherer D, Hemminki K, Rudnai P, Gurzau E, Koppova K, Botella-Estrada R, Soriano V, Juberias P, Saez B, Gilaberte Y, Fuentelsaz V, Corredera C, Grasa M, Höiom V, Lindblom A, Bonenkamp JJ, van Rossum MM, Aben KK, de Vries E, Santinami M, Di Mauro MG, Maurichi A, Wendt J, Hochleitner P, Pehamberger H, Gudmundsson J, Magnusdottir DN, Gretarsdottir S, Holm H, Steinthorsdottir V, Frigge ML, Blondal T, Saemundsdottir J, Bjarnason H, Kristjansson K, Bjornsdottir G, Okamoto I, Rivoltini L, Rodolfo M, Kiemeney LA, Hansson J, Nagore E, Mayordomo JI, Kumar R, Karagas MR, Nelson HH, Gulcher JR, Rafnar T, Thorsteinsdottir U, Olafsson JH, Kong A, Stefansson K. Evaluating new candidate SNPs as low penetrance risk factors in sporadic breast cancer: a two-stage Spanish case-control study.
Vega A, Salas A, Milne RL, Carracedo B, Ribas G, Ruibal A, de León AC, González-Hernández A, Benítez J, Carracedo A. | 11/5/2008 |
| LYRIC/AEG-1 is a negative regulator of BCCIPalpha, promoting proteasomal degradation either through direct interaction, or potentially through an indirect mechanism involving downstream effects of the NF-kappaB signaling pathway. | LYRIC/AEG-1 overexpression modulates BCCIPalpha protein levels in prostate tumor cells.
Ash SC, Yang DQ, Britt DE., Free PMC Article | 01/21/2010 |
| BCCIP-dependent repair of double strand breaks by homologous recombination is an early RAD51 response to ionizing radiation-induced DNA damage. | Distinct RAD51 associations with RAD52 and BCCIP in response to DNA damage and replication stress.
Wray J, Liu J, Nickoloff JA, Shen Z., Free PMC Article | 01/21/2010 |
| suggest an essential role of BCCIP in the maintenance of genomic integrity | Roles of BCCIP in chromosome stability and cytokinesis.
Meng X, Fan J, Shen Z., Free PMC Article | 01/21/2010 |
| BRCA2 germline mutations appear to have a milder clinical phenotype when compared to non-BRCA2 mutations, since survival is higher among breast cancer patients carrying a BRCA2 mutation compared to sporadic breast cancers. | BRCA2 gene mutations in Greek patients with familial breast cancer.
Armakolas A, Ladopoulou A, Konstantopoulou I, Pararas B, Gomatos IP, Kataki A, Konstadoulakis MM, Stathopoulos GP, Markopoulos C, Leandros E, Gogas I, Yannoukakos D, Androulakis G. | 01/21/2010 |
| In BRCA2, two novel frame shift mutations were identified as 5073-5074delCT and 6866delC. | Novel germline BRCA1 and BRCA2 mutations in breast and breast/ovarian cancer families from the Czech Republic.
Machackova E, Damborsky J, Valik D, Foretova L. | 01/21/2010 |
| BCCIP is critical for BRCA2- and RAD51-dependent responses to DNA damage and homologous recombinational repair. | The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.
Lu H, Guo X, Meng X, Liu J, Allen C, Wray J, Nickoloff JA, Shen Z., Free PMC Article | 01/21/2010 |
| Overexpression of BCCIP beta delays the G1 to S progression and results in an elevated p21 expression | Inhibition of G1 to S cell cycle progression by BCCIP beta.
Meng X, Liu J, Shen Z. | 01/21/2010 |