| MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis. | MicroRNA-141-regulated KLK10 and TNFSF-15 gene expression in hepatoblastoma cells as a novel mechanism in liver carcinogenesis.
Awad AM, Dabous E, Alalem M, Alalem N, Nasr ME, Elawdan KA, Nasr GM, Said W, El Khashab K, Basiouny MS, Guirgis AA, Khalil H., Free PMC Article | 06/26/2024 |
| KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation. | KLK10 derived from tumor endothelial cells accelerates colon cancer cell proliferation and hematogenous liver metastasis formation.
Kato K, Noda T, Kobayashi S, Sasaki K, Iwagami Y, Yamada D, Tomimaru Y, Takahashi H, Uemura M, Asaoka T, Shimizu J, Doki Y, Eguchi H., Free PMC Article | 06/3/2024 |
| KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway. | KLK10 promotes the progression of KRAS mutant colorectal cancer via PAR1-PDK1-AKT signaling pathway.
Wu K, Wu B, Yan K, Ding Q, Miao Z. | 03/13/2024 |
| Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer. | Kallikrein-related peptidase 10 predicts prognosis and mediates tumor immunomodulation in colorectal cancer.
Luo YC, Lv YL, He RX, Shi XX, Jiang T. | 12/1/2023 |
| Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia. | Prospective quantitative gene expression analysis of kallikrein-related peptidase KLK10 as a diagnostic biomarker for childhood acute lymphoblastic leukemia.
Ahmad SM, Ahmed BS, Khidhir KG, Rahman HS., Free PMC Article | 01/21/2023 |
| miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10. | miR-194-3p represses the docetaxel resistance in colon cancer by targeting KLK10.
Zhao J, Wang Y, Wang Y, Gao J, Wu X, Li H. | 08/13/2022 |
| MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10. | MiR-194-3p modulates the progression of colorectal cancer by targeting KLK10.
Liu T, Fang Y. | 06/18/2022 |
| The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility. | The Role of Kallikrein10 (KLK10) Polymorphism in Prostate Cancer Susceptibility.
Güleç Yılmaz S, Yencilek F, Yıldırım A, Akdeniz FT, Dalan AB, Barut Z, İsbir T. | 03/26/2022 |
| Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway. | Kallikrein-related peptidase (KLK10) cessation blunts colorectal cancer cell growth and glucose metabolism by regulating the PI3K/Akt/mTOR pathway.
Wei H, Dong C, Shen Z. | 11/21/2020 |
| The data suggest that via inhibition of BCL-2 expression, overexpressed NES1 might enhance the effect of radiation therapy of (131)I uptake in hNIS overexpressed PC3 cells. | NES1/KLK10 and hNIS gene therapy enhanced iodine-131 internal radiation in PC3 proliferation inhibition.
Hu J, Shen W, Qu Q, Fei X, Miao Y, Huang X, Liu J, Wu Y, Li B. | 05/23/2020 |
| findings show that KLK10 promotes trastuzumab resistance, at least in part, through the PI3K/AKT signaling pathway, suggesting that KLK10 is a potentially target to overcome trastuzumab resistance, and the combination might overcome trastuzumab resistance in KLK10-overexpressed gastric cancer patients. | NES1/KLK10 promotes trastuzumab resistance via activation of PI3K/AKT signaling pathway in gastric cancer.
Tang L, Long Z, Zhao N, Feng G, Guo X, Yu M. | 05/18/2019 |
| MiR-199b-5p promotes cell proliferation, migration and suppresses apoptosis in cervical cancer cells. KLK10 is a direct target of miR-199b-5p. MiR-199b-5p expression is increased and positively correlated with KI-67 in human cervical cancer tissues and cell lines. | MiR-199b-5p promotes tumor growth and metastasis in cervical cancer by down-regulating KLK10.
Xu LJ, Duan Y, Wang P, Yin HQ. | 12/22/2018 |
| blockade of KLK10 attenuates epithelial-mesenchymal transition and activation of FAK-SRC-ERK signaling, which explains the mechanism of KLK10 in promoting metastasis. | Aberrant upregulation of KLK10 promotes metastasis via enhancement of EMT and FAK/SRC/ERK axis in PDAC.
Cao XY, Zhang XX, Yang MW, Hu LP, Jiang SH, Tian GA, Zhu LL, Li Q, Sun YW, Zhang ZG. | 10/13/2018 |
| To the best of our knowledge, this is the first report on KLK10 exon 3 unmethylated PCR product concentration as potential early epigenetic diagnostic marker in primary ovarian tumors. | KLK10 exon 3 unmethylated PCR product concentration: a new potential early diagnostic marker in ovarian cancer? - A pilot study.
El Sherbini MA, Mansour AA, Sallam MM, Shaban EA, Shehab ElDin ZA, El-Shalakany AH., Free PMC Article | 09/29/2018 |
| KLK10 was verified to be a potential therapeutic target for reversing trastuzumab resistance in breast cancer cells. | Identification of KLK10 as a therapeutic target to reverse trastuzumab resistance in breast cancer.
Wang Z, Ruan B, Jin Y, Zhang Y, Li J, Zhu L, Xu W, Feng L, Jin H, Wang X., Free PMC Article | 02/24/2018 |
| Pronounced correlations between KLK10/KLK11 (rs = 0.647) and between KLK9/KLK15 (rs = 0.716) mRNA, but not between other combinations, indicate coordinate expression of distinct pairs of peptidases | Clinical relevance of kallikrein-related peptidase 9, 10, 11, and 15 mRNA expression in advanced high-grade serous ovarian cancer.
Geng X, Liu Y, Diersch S, Kotzsch M, Grill S, Weichert W, Kiechle M, Magdolen V, Dorn J., Free PMC Article | 12/9/2017 |
| identification and molecular cloning of eight novel transcripts of the human KLK10 gene using 3' rapid amplification of cDNA ends (3' RACE) and next-generation sequencing (NGS), as well as their expression analysis in a wide panel of cell lines, originating from several distinct cancerous and normal tissues | Identification and molecular cloning of novel transcripts of the human kallikrein-related peptidase 10 (KLK10) gene using next-generation sequencing.
Adamopoulos PG, Kontos CK, Scorilas A. | 10/7/2017 |
| Data suggest that mature KLK9 (kallikrein 9) is a glycosylated chymotrypsin-like enzyme with strong preference for tyrosine over phenylalanine at P1 cleavage position; substrate specificity of KLK9 appears to extend to KLK10 and midkine; enzyme activity is enhanced by Mg2+ and Ca2+, but is reversibly attenuated by Zn2+; KLK9 is inhibited in vitro by many naturally occurring or synthetic protease inhibitors. | Biochemical and functional characterization of the human tissue kallikrein 9.
Filippou PS, Farkona S, Brinc D, Yu Y, Prassas I, Diamandis EP. | 07/29/2017 |
| KLK10 potentially plays a crucial role in esophageal cancer cell growth. | Upregulated KLK10 inhibits esophageal cancer proliferation and enhances cisplatin sensitivity in vitro.
Li L, Xu N, Fan N, Meng Q, Luo W, Lv L, Ma W, Liu X, Liu L, Xu F, Wang H, Mao W, Li Y. | 04/29/2017 |
| KLK10 may function as a tumour suppressor by repressing proliferation, enhancing apoptosis and decreasing glucose metabolism in PC3 cells. | NES1/KLK10 gene represses proliferation, enhances apoptosis and down-regulates glucose metabolism of PC3 prostate cancer cells.
Hu J, Lei H, Fei X, Liang S, Xu H, Qin D, Wang Y, Wu Y, Li B., Free PMC Article | 10/22/2016 |
| treated and untreated prolactin-producing pituitary adenomas and carcinomas as well as TSH-producing pituitary adenomas and carcinomas were conclusively immunopositive for KLK10 | Human kallikrein 10 in surgically removed human pituitary adenomas.
Rotondo F, Di Ieva A, Kovacs K, Cusimano MD, Syro LV, Diamandis EP, Yousef GM. | 04/9/2016 |
| Immunoexpression of KLK10 in the ACTH-secreting tumors as well as in the Crooke cell tumors was significantly increased when compared with the nonfunctioning tumors and in the corticotrophs of non-tumorous pituitaries. | Human kallikrein 10 expression in surgically removed human pituitary corticotroph adenomas: an immunohistochemical study.
Di Meo A, Rotondo F, Kovacs K, Cusimano MD, Syro LV, Di Ieva A, Diamandis EP, Yousef GM. | 04/9/2016 |
| Data indicate that elevated expression of microRNA-375 in head and neck squamous cell carcinoma (HNSCC) cells significantly reduces kallikrein 6 (KLK6), kallikrein 10 (KLK10), and matrix metalloproteinase 9 (MMP9) messenger RNA expression. | MicroRNA-375 Suppresses Extracellular Matrix Degradation and Invadopodial Activity in Head and Neck Squamous Cell Carcinoma.
Jimenez L, Sharma VP, Condeelis J, Harris T, Ow TJ, Prystowsky MB, Childs G, Segall JE., Free PMC Article | 03/19/2016 |
| is the first correlation of oral squamous cell carcinoma with KLK10 rs3745535G>T polymorphisms | Polymorphisms in Kallikrein7 and 10 genes and oral cancer risks in Taiwan betel quid chewers and smokers.
Wang YY, Lin YC, Hung HC, Tien WY, Shieh TY. | 09/26/2015 |
| KLK6 and KLK10 may be useful markers and potential therapeutic targets in gastroesophageal junction tumors | Evaluation of human tissue kallikrein-related peptidases 6 and 10 expression in early gastroesophageal adenocarcinoma.
Grin A, Samaan S, Tripathi M, Rotondo F, Kovacs K, Bassily MN, Yousef GM. | 06/20/2015 |