| A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion. | A KLK6 Activity-Based Probe Reveals a Role for KLK6 Activity in Pancreatic Cancer Cell Invasion.
Zhang L, Lovell S, De Vita E, Jagtap PKA, Lucy D, Goya Grocin A, Kjær S, Borg A, Hennig J, Miller AK, Tate EW., Free PMC Article | 12/24/2022 |
| KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma. | KLK6 Functions as an Oncogene and Unfavorable Prognostic Factor in Bladder Urothelial Carcinoma.
Zhao K, Gao M, Lin M., Free PMC Article | 10/15/2022 |
| Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis. | Kallikrein-Related Peptidase 6 (KLK6) as a Contributor toward an Aggressive Cancer Cell Phenotype: A Potential Role in Colon Cancer Peritoneal Metastasis.
Bouzid H, Soualmia F, Oikonomopoulou K, Soosaipillai A, Walker F, Louati K, Lo Dico R, Pocard M, El Amri C, Ignatenko NA, Darmoul D., Free PMC Article | 07/30/2022 |
| Ectopic expression of KLK6 in MDA-MB-435 melanoma cells reduces tumorigenicity in vivo. | Ectopic expression of KLK6 in MDA-MB-435 melanoma cells reduces tumorigenicity in vivo.
Pampalakis G, Zingkou E, Zoumpourlis V, Sotiropoulou G. | 10/16/2021 |
| Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer. | Molecular Pathways Associated with Kallikrein 6 Overexpression in Colorectal Cancer.
Pandey R, Zhou M, Chen Y, Darmoul D, Kisiel CC, Nfonsam VN, Ignatenko NA., Free PMC Article | 09/4/2021 |
| Comprehensive Identification of the Human Secretome as Potential Indicators in Treatment Outcome of HPV-Positive and -Negative Cervical Cancer Patients. | Comprehensive Identification of the Human Secretome as Potential Indicators in Treatment Outcome of HPV-Positive and -Negative Cervical Cancer Patients.
Kong L, Wang J, Cheng J, Zang C, Chen F, Wang W, Zhao H, Wang Y, Wang D. | 04/13/2021 |
| KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease. | KLK6 expression in skin induces PAR1-mediated psoriasiform dermatitis and inflammatory joint disease.
Billi AC, Ludwig JE, Fritz Y, Rozic R, Swindell WR, Tsoi LC, Gruzska D, Abdollahi-Roodsaz S, Xing X, Diaconu D, Uppala R, Camhi MI, Klenotic PA, Sarkar MK, Husni ME, Scher JU, McDonald C, Kahlenberg JM, Midura RJ, Gudjonsson JE, Ward NL., Free PMC Article | 02/6/2021 |
| Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of alpha-synuclein in multiple system atrophy. | Exploring the putative role of kallikrein-6, calpain-1 and cathepsin-D in the proteolytic degradation of α-synuclein in multiple system atrophy.
Kiely AP, Miners JS, Courtney R, Strand C, Love S, Holton JL. | 08/22/2020 |
| previously unknown pathways implicating KLK6 in breast cancer, are reported. | Biochemical pathways mediated by KLK6 protease in breast cancer.
Pampalakis G, Zingkou E, Sidiropoulos KG, Diamandis EP, Zoumpourlis V, Yousef GM, Sotiropoulou G., Free PMC Article | 06/20/2020 |
| KLK6 expression is significantly downregulated in healthy palatal mucosa of smokers | Whole transcriptome analysis of smoker palatal mucosa identifies multiple downregulated innate immunity genes.
Wang Y, Anderson EP, Tatakis DN. | 11/18/2019 |
| KLK6 is an important molecular link in the development of skin inflammation. | KLK6 protease accelerates skin tumor formation and progression.
Khoury N, Zingkou E, Pampalakis G, Sofopoulos M, Zoumpourlis V, Sotiropoulou G. | 06/15/2019 |
| High KLK6 expression is associated with metastasis of colon cancer. | Let‑7i‑5p inhibits the proliferation and metastasis of colon cancer cells by targeting kallikrein‑related peptidase 6.
Song J, Wang L, Ma Q, Yang Y, Yang Z, Wang B, He N. | 11/3/2018 |
| Results showed a significant downregulation of KLK6 mRNA expression in breast cancer (BC) tissue sections compared to the non-cancerous component. The expression of KLK6 is positively associated with tumor grade and is overexpressed in aggressive phenotypes such as TNBC. | Kallikrein-related peptidase 6 (KLK6) expression differentiates tumor subtypes and predicts clinical outcome in breast cancer patients.
Haritos C, Michaelidou K, Mavridis K, Missitzis I, Ardavanis A, Griniatsos J, Scorilas A. | 09/15/2018 |
| KLK6-PAR2 expression is down-regulated and PAR1 is up-regulated when DeltaNp63beta expression is decreased, leading to EMT with enhancing migration and invasion through ERK signal reduction at the invasive front | Differential roles of kallikrein-related peptidase 6 in malignant transformation and ΔNp63β-mediated epithelial-mesenchymal transition of oral squamous cell carcinoma.
Kaneko N, Kawano S, Yasuda K, Hashiguchi Y, Sakamoto T, Matsubara R, Goto Y, Jinno T, Maruse Y, Morioka M, Hattori T, Tanaka S, Tanaka H, Kiyoshima T, Nakamura S. | 08/11/2018 |
| KLK6 may be the key protease involved in the proteolytic modification of PFK-M. | Kallikrein-related peptidase 6 can cleave human-muscle-type 6-phosphofructo-1-kinase into highly active shorter fragments.
Andrejc D, Legiša M. | 08/4/2018 |
| Our data demonstrate for the first time increased levels of KLK6 in mucosal melanomas of the head and neck | Expression of Kallikrein-Related Peptidase 6 in Primary Mucosal Malignant Melanoma of the Head and Neck.
Thierauf J, Veit JA, Lennerz JK, Weissinger SE, Affolter A, Döscher J, Bergmann C, Knopf A, Grünow J, Grünmüller L, Mauch C, Plinkert PK, Hoffmann TK, Hess J., Free PMC Article | 07/28/2018 |
| Induction of autophagic processes through KLK6 expression may increase acquisition of resistance of gastric cancer cells to auranofin-induced autophagy. | Kallikrein-related peptidase 6 induces chemotherapeutic resistance by attenuating auranofin-induced cell death through activation of autophagy in gastric cancer.
Kim TW, Lee SJ, Kim JT, Kim SJ, Min JK, Bae KH, Jung H, Kim BY, Lim JS, Yang Y, Yoon DY, Choe YK, Lee HG., Free PMC Article | 02/24/2018 |
| Our data provide experimental evidence that KLK6 controls metastasis formation in colon cancer via specific downstream network of miRNA-mRNA effectors. | Specific microRNA-mRNA Regulatory Network of Colon Cancer Invasion Mediated by Tissue Kallikrein-Related Peptidase 6.
Sells E, Pandey R, Chen H, Skovan BA, Cui H, Ignatenko NA., Free PMC Article | 02/24/2018 |
| Data show that kallikrein 6 (KLK6) expression is induced in mouse and human skin during chronic glucocorticoid treatment. | Important role of kallikrein 6 for the development of keratinocyte proliferative resistance to topical glucocorticoids.
Kishibe M, Baida G, Bhalla P, Lavker RM, Schlosser B, Iinuma S, Yoshida S, Dudley JT, Budunova I., Free PMC Article | 02/17/2018 |
| FST and KLK6 may have significance in breast cancer detection | An integrated cell line-based discovery strategy identified follistatin and kallikrein 6 as serum biomarker candidates of breast carcinoma.
Mangé A, Dimitrakopoulos L, Soosaipillai A, Coopman P, Diamandis EP, Solassol J. | 11/26/2017 |
| KLK6 overexpression and likely its proteolytic activity is associated with alterations in downstream miRNAs and their targets, and these differ with the molecular subtypes of breast cancer. | KLK6-regulated miRNA networks activate oncogenic pathways in breast cancer subtypes.
Sidiropoulos KG, Ding Q, Pampalakis G, White NM, Boulos P, Sotiropoulou G, Yousef GM., Free PMC Article | 11/11/2017 |
| Molecular models of peptides were built into the KLK6 structure and the marked preference of the cut between the two R of the examined peptides was related to the extended conformation of the substrates | Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?
Silva RN, Oliveira LCG, Parise CB, Oliveira JR, Severino B, Corvino A, di Vaio P, Temussi PA, Caliendo G, Santagada V, Juliano L, Juliano MA. | 07/22/2017 |
| Our fine-mapping study has identified novel loci in the KLK6 region strongly associated with aggressive PCa. | Germline Mutations in the Kallikrein 6 Region and Predisposition for Aggressive Prostate Cancer.
Briollais L, Ozcelik H, Xu J, Kwiatkowski M, Lalonde E, Sendorek DH, Fleshner NE, Recker F, Kuk C, Olkhov-Mitsel E, Savas S, Hanna S, Juvet T, Hunter GA, Friedlander M, Li H, Chadwick K, Prassas I, Soosaipillai A, Randazzo M, Trachtenberg J, Toi A, Shiah YJ, Fraser M, van der Kwast T, Bristow RG, Bapat B, Diamandis EP, Boutros PC, Zlotta AR. | 07/15/2017 |
| mRNA expression levels of KLK6 and KLK8 in advanced serous ovarian cancer | Clinical relevance of kallikrein-related peptidase 6 (KLK6) and 8 (KLK8) mRNA expression in advanced serous ovarian cancer.
Ahmed N, Dorn J, Napieralski R, Drecoll E, Kotzsch M, Goettig P, Zein E, Avril S, Kiechle M, Diamandis EP, Schmitt M, Magdolen V., Free PMC Article | 07/8/2017 |
| Data demonstrate that elevated levels of KLK6, KLK7 and KLK9 proteins are associated with poor glioblastoma patients survival. | Prognostic significance of multiple kallikreins in high-grade astrocytoma.
Drucker KL, Gianinni C, Decker PA, Diamandis EP, Scarisbrick IA., Free PMC Article | 05/14/2016 |