| Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer. | Expression of the membrane tetraspanin claudin 18 on cancer cells promotes T lymphocyte infiltration and antitumor immunity in pancreatic cancer.
De Sanctis F, Dusi S, Caligola S, Anselmi C, Petrova V, Rossi B, Angelini G, Erdeljan M, Wöll S, Schlitter AM, Metzler T, Steiger K, Borok Z, Bailey P, Bauer A, Halin C, Boschi F, Giugno R, Canè S, Lawlor R, Corbo V, Scarpa A, Constantin G, Ugel S, Vascotto F, Sahin U, Türeci Ö, Bronte V. | 06/25/2024 |
| FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer. | FAP-targeted CAR-T suppresses MDSCs recruitment to improve the antitumor efficacy of claudin18.2-targeted CAR-T against pancreatic cancer.
Liu Y, Sun Y, Wang P, Li S, Dong Y, Zhou M, Shi B, Jiang H, Sun R, Li Z., Free PMC Article | 04/15/2023 |
| Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs. | Deficiency of lung-specific claudin-18 leads to aggravated infection with Cryptococcus deneoformans through dysregulation of the microenvironment in lungs.
Sato K, Matsumoto I, Suzuki K, Tamura A, Shiraishi A, Kiyonari H, Kasamatsu J, Yamamoto H, Miyasaka T, Tanno D, Miyahara A, Zong T, Kagesawa T, Oniyama A, Kawamura K, Kitai Y, Umeki A, Kanno E, Tanno H, Ishii K, Tsukita S, Kawakami K., Free PMC Article | 01/29/2022 |
| Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells. | Claudin-18 Loss Alters Transcellular Chloride Flux but not Tight Junction Ion Selectivity in Gastric Epithelial Cells.
Caron TJ, Scott KE, Sinha N, Muthupalani S, Baqai M, Ang LH, Li Y, Turner JR, Fox JG, Hagen SJ., Free PMC Article | 12/25/2021 |
| Results found that Cldn18 deficiency induced the development of gastric tumors under chronic active gastritis in the absence of H pylori infection. Age-dependent changes in several signaling networks involving inflammation-, stemness-, and Wnt-related pathways, may accelerate this gastric tumorigenesis in a multi-faceted manner. | Deficiency of Stomach-Type Claudin-18 in Mice Induces Gastric Tumor Formation Independent of H pylori Infection.
Suzuki K, Sentani K, Tanaka H, Yano T, Suzuki K, Oshima M, Yasui W, Tamura A, Tsukita S., Free PMC Article | 04/11/2020 |
| expression associated with peripheral lung epithelial cell maturation and plays a key role in the corticosteroid-induced expression of surfactant proteins | Claudin18 associated with corticosteroid-induced expression of surfactant proteins in pulmonary epithelial cells.
Shi F, Liao Y, Dong Y, Wang Y, Xie Y, Wan H. | 11/30/2019 |
| claudin family member highly expressed in lung alveolar epithelium, leads to lung enlargement, parenchymal expansion, increased abundance and proliferation of known distal lung progenitors, the alveolar epithelial type II (AT2) cells, activation of Yes-associated protein (YAP), increased organ size, and tumorigenesis in mice | Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis.
Zhou B, Flodby P, Luo J, Castillo DR, Liu Y, Yu FX, McConnell A, Varghese B, Li G, Chimge NO, Sunohara M, Koss MN, Elatre W, Conti P, Liebler JM, Yang C, Marconett CN, Laird-Offringa IA, Minoo P, Guan K, Stripp BR, Crandall ED, Borok Z., Free PMC Article | 07/20/2019 |
| Lack of CAIX results in persistent acid backflux via claudin-18 downregulation, causing loss of parietal cells, hypergastrinaemia and foveolar hyperplasia. | Genetic ablation of carbonic anhydrase IX disrupts gastric barrier function via claudin-18 downregulation and acid backflux.
Li T, Liu X, Riederer B, Nikolovska K, Singh AK, Mäkelä KA, Seidler A, Liu Y, Gros G, Bartels H, Herzig KH, Seidler U., Free PMC Article | 07/20/2019 |
| The presented data substantiate the hypothesis that claudin-18 is a central barrier-forming component of tight junctions and show that IL-13 downregulates claudin-18. These data also suggest that the loss of claudin-18 is associated with increased sensitization to aeroantigens and airway responsiveness | Claudin-18 deficiency is associated with airway epithelial barrier dysfunction and asthma.
Sweerus K, Lachowicz-Scroggins M, Gordon E, LaFemina M, Huang X, Parikh M, Kanegai C, Fahy JV, Frank JA., Free PMC Article | 07/22/2017 |
| The claudin-18 knockout mice exhibited decreased P2X7 mRNA transcript abundance as measured by mRNA expression microarray | P2X7R-dependent regulation of glycogen synthase kinase 3β and claudin-18 in alveolar epithelial type I cells of mice lung.
Barth K, Bläsche R, Neißer A, Bramke S, Frank JA, Kasper M. | 06/24/2017 |
| CLDN18 deficiency results in epithelial barrier dysfunction, injury, and impaired alveolarization in mice. | Claudin-18 deficiency results in alveolar barrier dysfunction and impaired alveologenesis in mice.
LaFemina MJ, Sutherland KM, Bentley T, Gonzales LW, Allen L, Chapin CJ, Rokkam D, Sweerus KA, Dobbs LG, Ballard PL, Frank JA., Free PMC Article | 11/29/2014 |
| Identify a role for claudin 18 in alveolar fluid homeostasis beyond its direct contributions to barrier properties. | Knockout mice reveal key roles for claudin 18 in alveolar barrier properties and fluid homeostasis.
Li G, Flodby P, Luo J, Kage H, Sipos A, Gao D, Ji Y, Beard LL, Marconett CN, DeMaio L, Kim YH, Kim KJ, Laird-Offringa IA, Minoo P, Liebler JM, Zhou B, Crandall ED, Borok Z., Free PMC Article | 10/4/2014 |
| we conclude that the estrogen effects on osteoclasts may in part be mediated via regulation of Cldn-18 signaling | Disruption of claudin-18 diminishes ovariectomy-induced bone loss in mice.
Kim HY, Alarcon C, Pourteymour S, Wergedal JE, Mohan S., Free PMC Article | 04/20/2013 |
| Cldn-18 is a novel negative regulator of bone resorption and osteoclast differentiation | Claudin 18 is a novel negative regulator of bone resorption and osteoclast differentiation.
Linares GR, Brommage R, Powell DR, Xing W, Chen ST, Alshbool FZ, Lau KH, Wergedal JE, Mohan S., Free PMC Article | 11/17/2012 |
| Claudin-18 forms a paracellular barrier against H(+) in the stomach. Deficiency causes paracellular H(+) leak, up-regulation of proinflammatory cytokines, recruitment of neutrophils, and atrophic gastritis. | Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice.
Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Sentani K, Yasui W, Rakugi H, Isaka Y, Tsukita S. | 05/12/2012 |
| Increased expression of claudin-18 is associated with ulcerative colitis. | Increased expression of the tight junction molecule claudin-18 A1 in both experimental colitis and ulcerative colitis.
Zwiers A, Fuss IJ, Leijen S, Mulder CJ, Kraal G, Bouma G. | 01/21/2010 |
| Claudin-18 is expressed at the variety of epithelial tissues in inner ear including Organ of Corti, stria vascularis, Reissner's membrane, spiral limbus, vestibular sensory epithelia, and dark cell area. | Expression patterns of claudins, tight junction adhesion molecules, in the inner ear.
Kitajiri SI, Furuse M, Morita K, Saishin-Kiuchi Y, Kido H, Ito J, Tsukita S. | 12/5/2012 |