| Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis. | Hepatocyte-derived MASP1-enriched small extracellular vesicles activate HSCs to promote liver fibrosis.
Liu X, Tan S, Liu H, Jiang J, Wang X, Li L, Wu B. | 03/23/2023 |
| Identification of substrates of MBL Associated Serine Protease-1 (MASP-1) from human plasma using N-terminomics strategy. | Identification of substrates of MBL Associated Serine Protease-1 (MASP-1) from human plasma using N-terminomics strategy.
Bhagwat SR, Choudhary K, Pandya N, Sharma S, Srivastava S, Kumar A, Hajela K. | 10/22/2022 |
| Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma. | Comprehensive analysis of the immune and prognostic implication of MASP1 in stomach adenocarcinoma.
Zhang CH, Xu ZQ, Peng LL, Wang JJ, Gu HT. | 10/15/2022 |
| MASP1 Gene Polymorphism and MASP-3 Serum Levels in Patients with Chronic Chagas Disease. | MASP1 Gene Polymorphism and MASP-3 Serum Levels in Patients with Chronic Chagas Disease.
Oliveira Cavalcanti E, Freitas Lidani KC, de Freitas Oliveira Toré C, de Messias Reason IJ, Andrade FA. | 10/15/2022 |
| Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model. | Complement lectin pathway components MBL and MASP-1 promote haemostasis upon vessel injury in a microvascular bleeding model.
Golomingi M, Kohler J, Jenny L, Hardy ET, Dobó J, Gál P, Pál G, Kiss B, Lam WA, Schroeder V., Free PMC Article | 09/3/2022 |
| Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation. | Synergy of protease-binding sites within the ecotin homodimer is crucial for inhibition of MASP enzymes and for blocking lectin pathway activation.
Nagy ZA, Héja D, Bencze D, Kiss B, Boros E, Szakács D, Fodor K, Wilmanns M, Kocsis A, Dobó J, Gál P, Harmat V, Pál G., Free PMC Article | 07/2/2022 |
| MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes. | MicroRNA-122-5p regulates coagulation and inflammation through MASP1 and HO-1 genes.
Wang H, Zhang C, Zhang C, Wang Y, Zhai K, Tong Z. | 04/23/2022 |
| MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis. | MASP-1 and MASP-3 Bind Directly to Aspergillus fumigatus and Promote Complement Activation and Phagocytosis.
Rosbjerg A, Würzner R, Garred P, Skjoedt MO., Free PMC Article | 01/22/2022 |
| Mannose-binding lectin-associated serine protease-1 cleaves plasminogen and plasma fibronectin: prefers plasminogen over known fibrinogen substrate. | Mannose-binding lectin-associated serine protease-1 cleaves plasminogen and plasma fibronectin: prefers plasminogen over known fibrinogen substrate.
Choudhary K, Patel PK, Are VN, Makde RD, Hajela K. | 11/27/2021 |
| Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood. | Proprotein Convertase Is the Highest-Level Activator of the Alternative Complement Pathway in the Blood.
Oroszlán G, Dani R, Végh BM, Varga D, Ács AV, Pál G, Závodszky P, Farkas H, Gál P, Dobó J. | 08/28/2021 |
| Sacral protuberance with cleft lip and palate: Prenatal presentation of 3MC syndrome. | Sacral protuberance with cleft lip and palate: Prenatal presentation of 3MC syndrome.
Lawson C, Blakemore KJ, Ryan R, Hooper JE, Tsimis M, Jelin A., Free PMC Article | 05/1/2021 |
| Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome. | Association of Polymorphisms of MASP1/3, COLEC10, and COLEC11 Genes with 3MC Syndrome.
Gajek G, Świerzko AS, Cedzyński M., Free PMC Article | 04/17/2021 |
| C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1. | C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1.
Alberts A, Klingberg A, Wessig AK, Combes C, Witte T, Brand K, Pich A, Neumann K., Free PMC Article | 11/28/2020 |
| MASP-1 Increases Endothelial Permeability. | MASP-1 Increases Endothelial Permeability.
Debreczeni ML, Németh Z, Kajdácsi E, Schwaner E, Makó V, Masszi A, Doleschall Z, Rigó J, Walter FR, Deli MA, Pál G, Dobó J, Gál P, Cervenak L., Free PMC Article | 10/24/2020 |
| Polymorphisms regulating MASP-3/MAp44 availability in serum modulate leprosy susceptibility, underlining the importance of lectin pathway regulation against pathogens that exploit phagocytosis to parasitize host macrophages. | Adding MASP1 to the lectin pathway-Leprosy association puzzle: Hints from gene polymorphisms and protein levels.
Weinschutz Mendes H, Boldt ABW, von Rosen Seeling Stahlke E, Jensenius JC, Thiel S, Messias-Reason IJT., Free PMC Article | 07/4/2020 |
| Interactions of MASP-1 with the fibrinolytic system may be relevant in the development and therapy of cardiovascular and thrombotic diseases. | MASP-1 of the complement system alters fibrinolytic behaviour of blood clots.
Jenny L, Noser D, Larsen JB, Dobó J, Gál P, Pál G, Schroeder V. | 01/25/2020 |
| OPN selectively interacted with beta-Catenin and knockdown of beta-Catenin abrogated the effects induced by OPN. OPN recruited MAPK1 and activated MEK-MAPK1 pathway to mediate the S675 phosphorylation of beta-Catenin and nucleus accumulation, which induced the activation of Wnt signaling. | Osteopontin promotes metastasis of intrahepatic cholangiocarcinoma through recruiting MAPK1 and mediating Ser675 phosphorylation of β-Catenin.
Zheng Y, Zhou C, Yu XX, Wu C, Jia HL, Gao XM, Yang JM, Wang CQ, Luo Q, Zhu Y, Zhang Y, Wei JW, Sheng YY, Dong QZ, Qin LX., Free PMC Article | 11/30/2019 |
| Study results demonstrate a significant association of MASP1 polymorphism rs3774275 and MASP1 serum levels with the development of pulmonary tuberculosis in an Indian population. | AmpliSeq Screening of Genes Encoding the C-Type Lectin Receptors and Their Signaling Components Reveals a Common Variant in MASP1 Associated with Pulmonary Tuberculosis in an Indian Population.
Klassert TE, Goyal S, Stock M, Driesch D, Hussain A, Berrocal-Almanza LC, Myakala R, Sumanlatha G, Valluri V, Ahmed N, Schumann RR, Flores C, Slevogt H., Free PMC Article | 03/30/2019 |
| Using a specific and potent inhibitor of MASP-1, SGMI-1, as well as other MASP-1 inhibitors with different mechanisms of action, the authors demonstrated that, in addition to its functions in the lectin pathway, MASP-1 is essential for bacterial Lipopolysaccharide-induced alternative complement pathway activation, whereas it has little effect on zymosan-induced alternative complement pathway activation. | Cutting Edge: A New Player in the Alternative Complement Pathway, MASP-1 Is Essential for LPS-Induced, but Not for Zymosan-Induced, Alternative Pathway Activation.
Paréj K, Kocsis A, Enyingi C, Dani R, Oroszlán G, Beinrohr L, Dobó J, Závodszky P, Pál G, Gál P. | 02/23/2019 |
| PTX-3 and MASP-3 enhanced prediction of myocardial infarction compared to the traditional Framingham risk score alone | Pentraxin 3, ficolin-2 and lectin pathway associated serine protease MASP-3 as early predictors of myocardial infarction - the HUNT2 study.
Vengen IT, Enger TB, Videm V, Garred P., Free PMC Article | 12/22/2018 |
| Study proposes that RaRF may be a factor in the resistance mechanism and thus a potential target for leukemia therapy using retinoic acid. | RaRF confers RA resistance by sequestering RAR to the nucleolus and regulating MCL1 in leukemia cells.
Youn H, Lee HK, Sohn HR, Park UH, Kim EJ, Youn B, Um SJ. | 10/20/2018 |
| We present the first case with an intragenic MASP1 deletion featuring 3MC syndrome. Our patient features typical 3MCS symptoms and a characteristic face but no cleft lip/palate. | Biallelic intragenic deletion in MASP1 in an adult female with 3MC syndrome.
Graul-Neumann LM, Mensah MA, Klopocki E, Uebe S, Ekici AB, Thiel CT, Reis A, Zweier C. | 10/13/2018 |
| Studies results provide evidence that Crohn's disease patients have an impairment in mannose-binding lectin-mannose-associated serine protease functional activity and that this defect is associated with mannose-binding lectin 2 and NOD2 variants. | Polymorphisms in the Mannose-Binding Lectin Gene are Associated with Defective Mannose-Binding Lectin Functional Activity in Crohn's Disease Patients.
Choteau L, Vasseur F, Lepretre F, Figeac M, Gower-Rousseau C, Dubuquoy L, Poulain D, Colombel JF, Sendid B, Jawhara S., Free PMC Article | 06/2/2018 |
| These results indicate that PLTP and MASP-1 can serve as plasma biomarkers for the early diagnosis and treatment of Age-related macular degeneration , which is critical for preventing Age-related macular degeneration -related blindness. | Proteomics-based identification and validation of novel plasma biomarkers phospholipid transfer protein and mannan-binding lectin serine protease-1 in age-related macular degeneration.
Kim HJ, Ahn SJ, Woo SJ, Hong HK, Suh EJ, Ahn J, Park JH, Ryoo NK, Lee JE, Kim KW, Park KH, Lee C., Free PMC Article | 05/19/2018 |
| MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked. | MASP-3 is the exclusive pro-factor D activator in resting blood: the lectin and the alternative complement pathways are fundamentally linked.
Dobó J, Szakács D, Oroszlán G, Kortvely E, Kiss B, Boros E, Szász R, Závodszky P, Gál P, Pál G., Free PMC Article | 05/12/2018 |