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    CCL28 C-C motif chemokine ligand 28 [ Homo sapiens (human) ]

    Gene ID: 56477, updated on 14-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma.

    Pericytes recruited by CCL28 promote vascular normalization after anti-angiogenesis therapy through RA/RXRA/ANGPT1 pathway in lung adenocarcinoma.
    Chen Y, Zhang Z, Pan F, Li P, Yao W, Chen Y, Xiong L, Wang T, Li Y, Huang G., Free PMC Article

    09/6/2024
    Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.

    Analysis of the mucosal chemokines CCL28, CXCL14, and CXCL17 in dry eye disease: An in vitro and clinical investigation.
    Domínguez-López A, Blanco-Vázquez M, Calderón-García AÁ, García-Vázquez C, González-García MJ, Calonge M, Enríquez-de-Salamanca A.

    03/28/2024
    LncRNA H19 aggravates primary graft dysfunction after lung transplantation via KLF5-mediated activation of CCL28.

    LncRNA H19 aggravates primary graft dysfunction after lung transplantation via KLF5-mediated activation of CCL28.
    Li J, Han Z, Zhu Z, Wei L.

    10/4/2023
    Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.

    Mucosal CCL28 Chemokine Improves Protection against Genital Herpes through Mobilization of Antiviral Effector Memory CCR10+CD44+ CD62L-CD8+ T Cells and Memory CCR10+B220+CD27+ B Cells into the Infected Vaginal Mucosa.
    Dhanushkodi NR, Prakash S, Quadiri A, Zayou L, Srivastava R, Tran J, Dang V, Shaik AM, Chilukurri A, Suzer B, Vera P, Sun M, Nguyen P, Lee A, Salem A, Loi J, Singer M, Nakayama T, Vahed H, Nesburn AB, BenMohamed L., Free PMC Article

    06/26/2023
    Serum CCL28 as a biomarker for diagnosis and evaluation of Sjogren's syndrome.

    Serum CCL28 as a biomarker for diagnosis and evaluation of Sjögren's syndrome.
    Yu X, Zhu F, Yu X, Wang J, Wu B, Li C.

    02/14/2023
    Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.

    Inhibition of CCL28/CCR10-Mediated eNOS Downregulation Improves Skin Wound Healing in the Obesity-Induced Mouse Model of Type 2 Diabetes.
    Chen Z, Haus JM, Chen L, Jiang Y, Sverdlov M, DiPietro LA, Xiong N, Wu SC, Koh TJ, Minshall RD., Free PMC Article

    10/8/2022
    CCL28 Downregulation Attenuates Pancreatic Cancer Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms.

    CCL28 Downregulation Attenuates Pancreatic Cancer Progression Through Tumor Cell-Intrinsic and -Extrinsic Mechanisms.
    Yan J, Yuan P, Gui L, Wang Z, Yin P, Gao WQ, Ma B., Free PMC Article

    03/12/2022
    Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation.

    Knockdown of CCL28 inhibits endometriosis stromal cell proliferation and invasion via ERK signaling pathway inactivation.
    Wu Y, Zhu F, Sun W, Shen W, Zhang Q, Chen H., Free PMC Article

    03/12/2022
    Expression of Chemokine CCL28 in Ulcerative Colitis Patients.

    Expression of Chemokine CCL28 in Ulcerative Colitis Patients.
    Lee DS, Lee KL, Jeong JB, Shin S, Kim SH, Kim JW., Free PMC Article

    09/25/2021
    Hypoxia Induces Overexpression of CCL28 to Recruit Treg Cells to Enhance Angiogenesis in Lung Adenocarcinoma.

    Hypoxia Induces Overexpression of CCL28 to Recruit Treg Cells to Enhance Angiogenesis in Lung Adenocarcinoma.
    Liu B, Wei C.

    03/6/2021
    this review discusses the role of CCL28 in innate and adaptive immunity

    CCL28 chemokine: An anchoring point bridging innate and adaptive immunity.
    Mohan T, Deng L, Wang BZ., Free PMC Article

    05/12/2018
    Results show that CCL28 expression was up-regulated under hypoxic condition in lung adenocarcinoma cells. Besides other effects on tumor biology such as immunosuppression, CCL28 could promote angiogenesis in lung adenocarcinoma by directly activating its receptor, CCR3, on microvascular endothelial cells.

    Hypoxia induced CCL28 promotes angiogenesis in lung adenocarcinoma by targeting CCR3 on endothelial cells.
    Huang G, Tao L, Shen S, Chen L., Free PMC Article

    04/28/2018
    our results show for the first time that CCL28 contributes to breast cancer progression through the ERK/MAPKmediated anti-apoptotic and metastatic signaling pathway. Antagonists of CCL28 and the MAPK signaling pathway may be used synergistically to treat breast cancer patients.

    CCL28 promotes breast cancer growth and metastasis through MAPK-mediated cellular anti-apoptosis and pro-metastasis.
    Yang XL, Liu KY, Lin FJ, Shi HM, Ou ZL., Free PMC Article

    04/21/2018
    HCC recruits Tregs to promote angiogenesis under hypoxic condition by upregulating CCL28 expression. These findings establish a link between Tregs and hypoxia in HCC growth and may provide a new potential therapeutic target for treating HCC.

    Hypoxia-induced CCL28 promotes recruitment of regulatory T cells and tumor growth in liver cancer.
    Ren L, Yu Y, Wang L, Zhu Z, Lu R, Yao Z., Free PMC Article

    03/3/2018
    CCL28 was absent in saliva of primary Sjogren's syndrome patients. This finding did not correlate with salivary IgA levels.

    Absence of salivary CCL28 in primary Sjögren's syndrome.
    Hernandez-Molina G, Burkhardt AM, Lima G, Zlotnik A, Betanzos JL, Bahena S, Llorente L.

    03/19/2016
    disease severity of atopic dermatitis in children is not correlated to the level of CCL28, but rather related to that of total IgE

    CCL28 Cannot Replace IgE for Severity by Objective SCORAD Index in Atopic Dermatitis in Children.
    Yoon JH, Nam Y, Song EY, Roh EY, Yoon HS, Shin S.

    12/19/2015
    CCL28-CCR3 interactions are involved in the homeostatic trafficking of CD4(+) T cells to the upper airways.

    A role for CCL28-CCR3 in T-cell homing to the human upper airway mucosa.
    Danilova E, Skrindo I, Gran E, Hales BJ, Smith WA, Jahnsen J, Johansen FE, Jahnsen FL, Baekkevold ES.

    09/5/2015
    High CCL28 gene methylation is associated with gastric tumor aggressiveness.

    Epigenetic clustering of gastric carcinomas based on DNA methylation profiles at the precancerous stage: its correlation with tumor aggressiveness and patient outcome.
    Yamanoi K, Arai E, Tian Y, Takahashi Y, Miyata S, Sasaki H, Chiwaki F, Ichikawa H, Sakamoto H, Kushima R, Katai H, Yoshida T, Sakamoto M, Kanai Y., Free PMC Article

    07/25/2015
    CCL28 is a potent growth-promoting factor with the ability to support the in vitro and in vivo functional properties of cultured human hematopoietic cells.

    Identification of the chemokine CCL28 as a growth and survival factor for human hematopoietic stem and progenitor cells.
    Karlsson C, Baudet A, Miharada N, Soneji S, Gupta R, Magnusson M, Enver T, Karlsson G, Larsson J.

    07/27/2013
    These results indicate a role for IL-17A in the human lung by enhancing the expression of CCL28 and hence driving the recruitment of IgE-secreting B cells.

    IL-17A induces CCL28, supporting the chemotaxis of IgE-secreting B cells.
    Scanlon KM, Hawksworth RJ, Lane SJ, Mahon BP.

    10/29/2011
    tumour hypoxia promotes the recruitment of regulatory T (T(reg)) cells through induction of expression of the chemokine CC-chemokine ligand 28 (CCL28), which, in turn, promotes tumour tolerance and angiogenesis

    Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells.
    Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, Gimotty PA, Gilks CB, Lal P, Zhang L, Coukos G.

    08/27/2011
    Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

    Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, Keavney B, Yusuf S, Gerstein HC, Engert JC, Anand S, DREAM investigators., Free PMC Article

    09/15/2010
    data reinforce concept that CCL28 may contribute to the pathogenesis of atopic dermatitis probably through selective migration & infiltration of effector/memory T-helper-2 cells in the skin; CCL28 may represent a prognostic marker for disease severity

    Serum mucosa-associated epithelial chemokine (MEC/CCL28) in atopic dermatitis: a specific marker for severity.
    Ezzat MH, Sallam MA, Shaheen KY.

    01/21/2010
    Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)

    Genetic susceptibility to respiratory syncytial virus bronchiolitis in preterm children is associated with airway remodeling genes and innate immune genes.
    Siezen CL, Bont L, Hodemaekers HM, Ermers MJ, Doornbos G, Van't Slot R, Wijmenga C, Houwelingen HC, Kimpen JL, Kimman TG, Hoebee B, Janssen R.

    03/25/2009
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (4) articles

    Interleukin-9 polymorphism in infants with respiratory syncytial virus infection: an opposite effect in boys and girls.
    Schuurhof A, Bont L, Siezen CL, Hodemaekers H, van Houwelingen HC, Kimman TG, Hoebee B, Kimpen JL, Janssen R.

    New genetic associations detected in a host response study to hepatitis B vaccine.
    Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M.

    Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium.

    Genetic susceptibility to respiratory syncytial virus bronchiolitis is predominantly associated with innate immune genes.
    Janssen R, Bont L, Siezen CL, Hodemaekers HM, Ermers MJ, Doornbos G, van 't Slot R, Wijmenga C, Goeman JJ, Kimpen JL, van Houwelingen HC, Kimman TG, Hoebee B.

    03/25/2009
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