| AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner. | AMBRA1 promotes intestinal inflammation by antagonizing PP4R1/PP4c mediated IKK dephosphorylation in an autophagy-independent manner.
Xu W, Hua Z, Wang Y, Tang W, Ou W, Liu F, Yang Y, Ding W, Wang Z, Cui L, Ge W, Gu Y, Wang X, Chen Y, Liu CY, Du P., | 07/16/2024 |
| Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice. | Oligoasthenoteratospermia and sperm tail bending in PPP4C-deficient mice.
Han F, Dong MZ, Lei WL, Xu ZL, Gao F, Schatten H, Wang ZB, Sun XF, Sun QY. | 10/9/2021 |
| The PP4 is indispensable for preventing DNA replication stress that could interfere with CSR, thereby promoting antibody switching during the humoral immune response. | PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency.
Chen MY, Hsu WC, Hsu SC, Yang YS, Chuang TH, Lin WJ, Tan TH, Su YW., Free PMC Article | 09/26/2020 |
| LCMT-1 homozygous knock-out MEFs exhibited hyperphosphorylation of HDAC3, a reported target of the methylation-dependent PP4R1-PP4c complex. Collectively, our data suggest that LCMT-1 coordinately regulates the carboxyl methylation of PP2A-related phosphatases and, consequently, their holoenzyme assembly and function. | Leucine Carboxyl Methyltransferase 1 (LCMT-1) Methylates Protein Phosphatase 4 (PP4) and Protein Phosphatase 6 (PP6) and Differentially Regulates the Stable Formation of Different PP4 Holoenzymes.
Hwang J, Lee JA, Pallas DC., Free PMC Article | 05/20/2017 |
| T cell-specific ablation of PP4 resulted in defective adaptive immunity, impaired T cell homeostatic expansion, and inefficient T cell proliferation. | T cell proliferation and adaptive immune responses are critically regulated by protein phosphatase 4.
Liao FH, Hsiao WY, Lin YC, Chan YC, Huang CY., Free PMC Article | 01/14/2017 |
| Data show that protein phosphatase 4 (PP4) is an important regulator in inflammatory related insulin resistance. | Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance.
Zhao H, Huang X, Jiao J, Zhang H, Liu J, Qin W, Meng X, Shen T, Lin Y, Chu J, Li J., Free PMC Article | 11/12/2016 |
| Thus, serine/threonine phosphatase PP4 functions as a novel feedback negative regulator of RNA virus-triggered innate immunity. | Phosphatase PP4 Negatively Regulates Type I IFN Production and Antiviral Innate Immunity by Dephosphorylating and Deactivating TBK1.
Zhan Z, Cao H, Xie X, Yang L, Zhang P, Chen Y, Fan H, Liu Z, Liu X. | 01/2/2016 |
| Taken together, our results establish a novel role for PP4 in CSR, and reveal crucial functions for PP4 in the maintenance of genomic stability, GC formation, and B cell-mediated immune responses. | PP4 is essential for germinal center formation and class switch recombination in mice.
Chen MY, Chen YP, Wu MS, Yu GY, Lin WJ, Tan TH, Su YW., Free PMC Article | 12/19/2015 |
| PP4 overexpression was observed to lead to a decreased pACC1Ser79/ACC1 ratio and subsequently an increased intracellular triglyceride content in mouse primary hepatocytes. | Protein phosphatase 4 promotes hepatic lipogenesis through dephosphorylating acetyl‑CoA carboxylase 1 on serine 79.
Meng X, Li M, Guo J, Tang W, Wang S, Man Y, Huang X, Li J. | 05/23/2015 |
| Mammalian SMEK/PP4C proteins are involved in the regulation of hepatic glucose metabolism through dephosphorylation of CRTC2. | Suppressor of MEK null (SMEK)/protein phosphatase 4 catalytic subunit (PP4C) is a key regulator of hepatic gluconeogenesis.
Yoon YS, Lee MW, Ryu D, Kim JH, Ma H, Seo WY, Kim YN, Kim SS, Lee CH, Hunter T, Choi CS, Montminy MR, Koo SH., Free PMC Article | 11/27/2010 |
| PP4 negatively regulated LPS-induced and TRAF6-mediated NF-kappaB activation by inhibiting the ubiquitination of TRAF6. | Protein phosphatase 4 negatively regulates LPS cascade by inhibiting ubiquitination of TRAF6.
Chen L, Dong W, Zou T, Ouyang L, He G, Liu Y, Qi Y. | 01/21/2010 |
| Protein phosphatase 4 has a role in apoptosis. | Functional expression cloning reveals proapoptotic role for protein phosphatase 4.
Mourtada-Maarabouni M, Kirkham L, Jenkins B, Rayner J, Gonda TJ, Starr R, Trayner I, Farzaneh F, Williams GT. | 01/21/2010 |
| PP4 is essential for thymocyte development and pre-TCR signaling | Conditional knockout mice reveal an essential role of protein phosphatase 4 in thymocyte development and pre-T-cell receptor signaling.
Shui JW, Hu MC, Tan TH., Free PMC Article | 01/21/2010 |