| AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments. | AEP-cleaved DDX3X induces alternative RNA splicing events to mediate cancer cell adaptation in harsh microenvironments.
Zhang W, Cao L, Yang J, Zhang S, Zhao J, Shi Z, Liao K, Wang H, Chen B, Qian Z, Xu H, Wu L, Liu H, Wang H, Ma C, Qiu Y, Ge J, Chen J, Lin Y., Free PMC Article | 02/9/2024 |
| c-Src regulates delta-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6. | c-Src regulates δ-secretase activation and truncated Tau production by phosphorylating the E3 ligase Traf6.
Jiang Y, Li L, Wu R, Wu L, Zhang B, Wang JZ, Liu R, Liu F, Wang J, Wang X., Free PMC Article | 01/31/2024 |
| Potential relevance of salivary legumain for the clinical diagnostic of hand, foot, and mouth disease. | Potential relevance of salivary legumain for the clinical diagnostic of hand, foot, and mouth disease.
Tan YW, Teo FMS, Ler SG, Alli-Shaik A, Nyo M, Chong CY, Tan NWH, Wang RYL, Gunaratne J, Chu JJH. | 11/30/2023 |
| Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque. | Relationship between Increased Plasma Levels of Legumain and Properties of Coronary Atherosclerotic Plaque.
Deng Y, Fan Y, Wu D, Zhang Z, Zhang M, Huang Z, Gao Y., Free PMC Article | 11/3/2023 |
| Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer. | Asparaginyl endopeptidase contributes to cetuximab resistance via MEK/ERK signaling in RAS wide-type metastatic colorectal cancer.
Xu X, Liu M, Peng K, Yu Y, Liu T., Free PMC Article | 02/27/2023 |
| Metformin regulates autophagy via LGMN to inhibit choriocarcinoma. | Metformin regulates autophagy via LGMN to inhibit choriocarcinoma.
Tu W, Qin M, Li Y, Wu W, Tong X. | 01/7/2023 |
| An infection-induced oxidation site regulates legumain processing and tumor growth. | An infection-induced oxidation site regulates legumain processing and tumor growth.
Kovalyova Y, Bak DW, Gordon EM, Fung C, Shuman JHB, Cover TL, Amieva MR, Weerapana E, Hatzios SK., Free PMC Article | 07/9/2022 |
| Legumain Is an Endogenous Modulator of Integrin alphavbeta3 Triggering Vascular Degeneration, Dissection, and Rupture. | Legumain Is an Endogenous Modulator of Integrin αvβ3 Triggering Vascular Degeneration, Dissection, and Rupture.
Pan L, Bai P, Weng X, Liu J, Chen Y, Chen S, Ma X, Hu K, Sun A, Ge J. | 03/12/2022 |
| Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene. | Identification of the Cysteine Protease Legumain as a Potential Chronic Hypoxia-Specific Multiple Myeloma Target Gene.
Clees AS, Stolp V, Häupl B, Fuhrmann DC, Wempe F, Seibert M, Weber S, Banning A, Tikkanen R, Williams R, Brüne B, Serve H, Schnütgen F, von Metzler I, Kurrle N., Free PMC Article | 02/26/2022 |
| C/EBPbeta/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis. | C/EBPβ/AEP Signaling Regulates the Oxidative Stress in Malignant Cancers, Stimulating the Metastasis.
Lei K, Kang SS, Ahn EH, Chen C, Liao J, Liu X, Li H, Edgington-Mitchell LE, Jin L, Ye K. | 02/12/2022 |
| Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis. | Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis.
Chen B, Wang M, Huang R, Liao K, Wang T, Yang R, Zhang W, Shi Z, Ren L, Lv Q, Ma C, Lin Y, Qiu Y. | 01/8/2022 |
| Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population. | Lack of association between LGMN and Alzheimer's disease in the Southern Han Chinese population.
Zhang X, Jiao B, Weng L, Zhou Y, Guo L, Wang X, Zhou L, Liu X, Xiao X, Liu H, Zhu X, Li C, Zhu Y, Yang Q, Lin Z, Jiang Y, Wen Y, Zhou H, Shen L, Liao X. | 09/4/2021 |
| ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase. | ADAM10 and ADAM17 are degraded by lysosomal pathway via asparagine endopeptidase.
Zhang X, Tang L, Zhang Z. | 04/24/2021 |
| Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis. | Down-regulation of lncRNA PCGEM1 inhibits cervical carcinoma by modulating the miR-642a-5p/LGMN axis.
Liu Y, Wang Y, Shen X, Chen C, Ni H, Sheng N, Hua M, Wu Y. | 02/6/2021 |
| The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma. | The LGMN pseudogene promotes tumor progression by acting as a miR-495-3p sponge in glioblastoma.
Liao K, Qian Z, Zhang S, Chen B, Li Z, Huang R, Cheng L, Wang T, Yang R, Lan J, Lu X, Kong L, Song X, Qiu Y, Lin Y. | 01/23/2021 |
| Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages. | Legumain is upregulated in acute cardiovascular events and associated with improved outcome - potentially related to anti-inflammatory effects on macrophages.
Lunde NN, Gregersen I, Ueland T, Shetelig C, Holm S, Kong XY, Michelsen AE, Otterdal K, Yndestad A, Broch K, Gullestad L, Nyman TA, Bendz B, Eritsland J, Hoffmann P, Skagen K, Gonçalves I, Nilsson J, Grenegård M, Poreba M, Drag M, Seljeflot I, Sporsheim B, Espevik T, Skjelland M, Johansen HT, Solberg R, Aukrust P, Björkbacka H, Andersen GØ, Halvorsen B. | 01/16/2021 |
| The exosomal integrin alpha5beta1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration. | The exosomal integrin α5β1/AEP complex derived from epithelial ovarian cancer cells promotes peritoneal metastasis through regulating mesothelial cell proliferation and migration.
Li X, Tang M, Zhu Q, Wang X, Lin Y, Wang X. | 12/12/2020 |
| Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma. | Role of Asparagine Endopeptidase in Mediating Wild-Type p53 Inactivation of Glioblastoma.
Lin Y, Liao K, Miao Y, Qian Z, Fang Z, Yang X, Nie Q, Jiang G, Liu J, Yu Y, Wan J, Zhang X, Hu Y, Jiang J, Qiu Y., Free PMC Article | 09/26/2020 |
| High legumain expression is associated with poor prognosis in breast ductal carcinoma in situ and could be a potential marker to predict DCIS progression to invasive disease. | Legumain is an independent predictor for invasive recurrence in breast ductal carcinoma in situ.
Toss MS, Miligy IM, Gorringe KL, McCaffrey L, AlKawaz A, Abidi A, Ellis IO, Green AR, Rakha EA. | 05/2/2020 |
| Clinically, serum Lgmn levels were closely associated with the severity of idiopathic PAH. The pulmonary vascular resistance and pulmonary arterial systolic pressure also showed a strong association with serum Lgmn levels. | Macrophage-Derived Legumain Promotes Pulmonary Hypertension by Activating the MMP (Matrix Metalloproteinase)-2/TGF (Transforming Growth Factor)-β1 Signaling.
Bai P, Lyu L, Yu T, Zuo C, Fu J, He Y, Wan Q, Wan N, Jia D, Lyu A. | 01/18/2020 |
| Study in different human cell lines and postmortem neurodegenerative diseases brain samples shows that BDNF-mediated Akt directly phosphorylates AEP on T322 and blocks AEP activation, sequestering it in lysosomes. BDNF reduction in neurodegenerative diseases elicits reduction of p-AEP T322, AEP cytoplasmic translocation, and subsequent activation, escalating its autocleavage and pathological substrate truncation. | BDNF inhibits neurodegenerative disease-associated asparaginyl endopeptidase activity via phosphorylation by AKT.
Wang ZH, Wu W, Kang SS, Liu X, Wu Z, Peng J, Yu SP, Manfredsson FP, Sandoval IM, Liu X, Wang JZ, Ye K., Free PMC Article | 12/14/2019 |
| Our study provides the first evidence that legumain contributes to the induction of atherosclerotic vascular remodeling. | Legumain Promotes Atherosclerotic Vascular Remodeling.
Ozawa N, Sato Y, Mori Y, Masuda H, Yamane M, Yamamoto Y, Shirai R, Watanabe R, Sato K, Mori Y, Hirano T, Watanabe T., Free PMC Article | 09/14/2019 |
| Studies identified Legumain (LGMN) as a new target which is highly expressed in the tumor microenvironment and in tumor cells. [review] | Targeting Legumain As a Novel Therapeutic Strategy in Cancers.
Mai CW, Chung FF, Leong CO. | 06/9/2018 |
| our results suggest that M2 tumour-associated macrophages affect degradation of the extracellular matrix and angiogenesis via overexpression of legumain, and therefore play an active role in the progression of DLBCL. | M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma.
Shen L, Li H, Shi Y, Wang D, Gong J, Xun J, Zhou S, Xiang R, Tan X., Free PMC Article | 04/28/2018 |
| Legumain regulates oxLDL-induced macrophage apoptosis by enhancing the autophagy pathway. | Legumain suppresses OxLDL-induced macrophage apoptosis through enhancement of the autophagy pathway.
Sun W, Lin Y, Chen L, Ma R, Cao J, Yao J, Chen K, Wan J. | 03/24/2018 |