| The ion channel TRPV5 regulates B-cell signaling and activation. | The ion channel TRPV5 regulates B-cell signaling and activation.
Mahtani T, Sheth H, Smith LK, Benedict L, Brecier A, Ghasemlou N, Treanor B., Free PMC Article | 05/7/2024 |
| Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis. | Alterations in the microenvironment and the effects produced of TRPV5 in osteoporosis.
Luo ZH, Ma JX, Zhang W, Tian AX, Gong SW, Li Y, Lai YX, Ma XL., Free PMC Article | 05/22/2023 |
| Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions. | Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.
Ali FT, El-Azeem EMA, Hekal HFA, El-Gizawy MM, Sayed MS, Mandoh AY, Soliman AF., Free PMC Article | 10/29/2022 |
| Association of TRPV5 gene polymorphism with calcium urolithiasis: a case-control study from West Bengal, India. | Association of TRPV5 gene polymorphism with calcium urolithiasis: a case-control study from West Bengal, India.
Mitra P, Pal DK, Das M. | 02/2/2021 |
| TRPV5 in renal tubular calcium handling and its potential relevance for nephrolithiasis. | TRPV5 in renal tubular calcium handling and its potential relevance for nephrolithiasis.
van der Wijst J, van Goor MK, Schreuder MF, Hoenderop JG. | 11/21/2020 |
| cryoelectron microscopic analysis of the structural basis for TRPV5 channel inhibition by econazole | Structural basis of TRPV5 channel inhibition by econazole revealed by cryo-EM.
Hughes TET, Lodowski DT, Huynh KW, Yazici A, Del Rosario J, Kapoor A, Basak S, Samanta A, Han X, Chakrapani S, Zhou ZH, Filizola M, Rohacs T, Han S, Moiseenkova-Bell VY., Free PMC Article | 07/27/2019 |
| rs4252424 was significantly associated with lead poisoning susceptibility, measured by blood lead level in Chinese workers. | Association between single nucleotide polymorphism (rs4252424) in TRPV5 calcium channel gene and lead poisoning in Chinese workers.
Liu J, Zhang L, Feng L, Xu M, Gao Y, Zhou P, Yu Z, Zhu B, An Y, Zhang H., Free PMC Article | 05/11/2019 |
| TRPV5 and TRPV6 lack a positively charged residue in the TM4-TM5 loop that was shown to interact with PI(4,5)P2 in TRPV1, which shows high affinity for this lipid | A molecular determinant of phosphoinositide affinity in mammalian TRPV channels.
Velisetty P, Borbiro I, Kasimova MA, Liu L, Badheka D, Carnevale V, Rohacs T., Free PMC Article | 05/26/2018 |
| The alterations may lead to misfolding of TRPV5, reduction in translocation of the channel to the plasma membrane and/or impaired Ca(2+) transport function of the channel, and ultimately disrupt TRPV5-mediated Ca(2+) reabsorption. | The L530R variation associated with recurrent kidney stones impairs the structure and function of TRPV5.
Wang L, Holmes RP, Peng JB., Free PMC Article | 10/28/2017 |
| These findings indicate that the A563T variation induces structural, dynamical, and electrostatic changes in the TRPV5 pore, providing structural insight into the functional alterations associated with the A563T variation. | Molecular Modeling of the Structural and Dynamical Changes in Calcium Channel TRPV5 Induced by the African-Specific A563T Variation.
Wang L, Holmes RP, Peng JB., Free PMC Article | 07/30/2016 |
| Data found that a TRPV5 polymorphism (rs4236480) was observed to be associated with stone multiplicity of calcium nephrolithiasis, as the risk of stone multiplicity was higher in patients with the TT+CT genotype than in patients with the CC genotype | A Single Nucleotide Polymorphism (rs4236480) in TRPV5 Calcium Channel Gene Is Associated with Stone Multiplicity in Calcium Nephrolithiasis Patients.
Khaleel A, Wu MS, Wong HS, Hsu YW, Chou YH, Chen HY., Free PMC Article | 02/13/2016 |
| High TRPV5 expression is aassociated with adenoma of parathyroid glands. | First evidence of TRPV5 and TRPV6 channels in human parathyroid glands: possible involvement in neoplastic transformation.
Giusti L, Cetani F, Da Valle Y, Pardi E, Ciregia F, Donadio E, Gargini C, Piano I, Borsari S, Jaber A, Caputo A, Basolo F, Giannaccini G, Marcocci C, Lucacchini A., Free PMC Article | 04/18/2015 |
| Klotho up-regulates TRPV5 from both the inside and outside of cells. | Klotho up-regulates renal calcium channel transient receptor potential vanilloid 5 (TRPV5) by intra- and extracellular N-glycosylation-dependent mechanisms.
Wolf MT, An SW, Nie M, Bal MS, Huang CL., Free PMC Article | 04/18/2015 |
| Decreased expression of TRPV5 is associated with non-small cell lung cancer. | Expression and prognostic roles of TRPV5 and TRPV6 in non-small cell lung cancer after curative resection.
Fan H, Shen YX, Yuan YF. | 01/10/2015 |
| Upregulating the expression of TRPV5 can be utilized to manipulate transmembrane Ca2+ transport, and may serve as an alternative for the treatment of Ca2+ balance-related diseases. | Induction of TRPV5 expression by small activating RNA targeting gene promoter as a novel approach to regulate cellular calcium transportation.
Yang B, Duan X, Wu W, Ji W, Wu W, Zhong W, Zhao Z, Li S, Liu Y, Zeng G. | 11/22/2014 |
| These results suggest that TRPV5 and TRPV6 are crucial gates controlling cadmium and zinc levels in the human body. | Human TRPV5 and TRPV6: key players in cadmium and zinc toxicity.
Kovacs G, Montalbetti N, Franz MC, Graeter S, Simonin A, Hediger MA. | 05/31/2014 |
| these data showed that TRPV5/TRPV6 in human lymphocytes are functionally active, and their activity is associated with proliferative status of blood cells. | [The functional characteristics oF TRPV5 and TRPV6 channels in normal and transformed human blood lymphocytes].
Tomilin VN, Vasil'eva IO, Marakhova II, Neguliaev IuA, Semenova CB. | 03/29/2014 |
| Data indicate that transient receptor potential vanilloid type 5 (TRPV5) plasma membrane retention is regulated via lipid rafts. | The epithelial calcium channel TRPV5 is regulated differentially by klotho and sialidase.
Leunissen EH, Nair AV, Büll C, Lefeber DJ, van Delft FL, Bindels RJ, Hoenderop JG., Free PMC Article | 12/14/2013 |
| TRPML3 and TRPV5 heteromers could have a biological function | A novel ion channel formed by interaction of TRPML3 with TRPV5.
Guo Z, Grimm C, Becker L, Ricci AJ, Heller S., Free PMC Article | 08/31/2013 |
| urinary plasmin could contribute to the downstream effects of proteinuria on the tubulointerstitium by negatively modulating TRPV5 | Urinary plasmin inhibits TRPV5 in nephrotic-range proteinuria.
Tudpor K, Laínez S, Kwakernaak AJ, Kovalevskaya NV, Verkaart S, van Genesen S, van der Kemp A, Navis G, Bindels RJ, Hoenderop JG., Free PMC Article | 01/12/2013 |
| The TRPV6 is a close homolog of TRPV5, yet their calmodulin binding sites display diversity in binding modes, binding stoichiometries and binding affinities which may fine-tune the response of the channels to varying Ca(2+)-concentrations. | The TRPV5/6 calcium channels contain multiple calmodulin binding sites with differential binding properties.
Kovalevskaya NV, Bokhovchuk FM, Vuister GW., Free PMC Article | 10/13/2012 |
| apically secreted tissue transglutaminase functions as an inhibitor of TRPV5 and thereby contributes to the regulation of body Ca2+ homeostasis. | Tissue transglutaminase inhibits the TRPV5-dependent calcium transport in an N-glycosylation-dependent manner.
Boros S, Xi Q, Dimke H, van der Kemp AW, Tudpor K, Verkaart S, Lee KP, Bindels RJ, Hoenderop JG., Free PMC Article | 04/7/2012 |
| Data show that calmodulin negatively modulates TRPV5 activity, which is reversed by parathyroid hormone-mediated channel phosphorylation. | Molecular mechanisms of calmodulin action on TRPV5 and modulation by parathyroid hormone.
de Groot T, Kovalevskaya NV, Verkaart S, Schilderink N, Felici M, van der Hagen EA, Bindels RJ, Vuister GW, Hoenderop JG., Free PMC Article | 10/8/2011 |
| Data show that TRPV5 and TRPV6 expression is decreased in PE. | Alteration of calcium homeostasis in primary preeclamptic syncytiotrophoblasts: effect on calcium exchange in placenta.
Haché S, Takser L, LeBellego F, Weiler H, Leduc L, Forest JC, Giguère Y, Masse A, Barbeau B, Lafond J., Free PMC Article | 07/23/2011 |
| A calmodulin binding site was located in the C-termini of TRPV2 (654-683) and TRPV5 (587-616). | Characterization of calmodulin binding domains in TRPV2 and TRPV5 C-tails.
Holakovska B, Grycova L, Bily J, Teisinger J. | 05/28/2011 |