| Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice. | Evaluating possible maternal effect lethality and genetic background effects in Naa10 knockout mice.
Lyon GJ, Longo J, Garcia A, Inusa F, Marchi E, Shi D, Dörfel M, Arnesen T, Aldabe R, Lyons S, Nashat MA, Bolton D., Free PMC Article | 06/3/2024 |
| Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway. | Naa12 compensates for Naa10 in mice in the amino-terminal acetylation pathway.
Kweon HY, Lee MN, Dorfel M, Seo S, Gottlieb L, PaPazyan T, McTiernan N, Ree R, Bolton D, Garcia A, Flory M, Crain J, Sebold A, Lyons S, Ismail A, Marchi E, Sonn SK, Jeong SJ, Jeon S, Ju S, Conway SJ, Kim T, Kim HS, Lee C, Roh TY, Arnesen T, Marmorstein R, Oh GT, Lyon GJ., Free PMC Article | 10/16/2021 |
| Naa10p-mediated N-terminal acetylation of Pgc1alpha downregulates thermogenic gene expression in beige adipocytes. | Naa10p Inhibits Beige Adipocyte-Mediated Thermogenesis through N-α-acetylation of Pgc1α.
Lee CC, Shih YC, Kang ML, Chang YC, Chuang LM, Devaraj R, Juan LJ. | 02/29/2020 |
| we established Naa10 knockout mESCs to test this hypothesis. We found that Naa10 deficiency attenuated differentiation towards the epiblast lineage, deviating towards primitive endoderm. | The N-end rule pathway enzyme Naa10 supports epiblast specification in mouse embryonic stem cells by modulating FGF/MAPK.
Takekoshi D, Tokuzawa Y, Sakanaka M, Kato H. | 09/7/2019 |
| Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. | Unc-5 homolog B (UNC5B) is one of the key downstream targets of N-α-Acetyltransferase 10 (Naa10).
Xu H, Han Y, Liu B, Li R., Free PMC Article | 06/9/2018 |
| The lethal Ogden syndrome-associated mutation of Naa10p disrupts its binding to the imprinting control region of H19 and Dnmt1 recruitment. | The Role of N-α-acetyltransferase 10 Protein in DNA Methylation and Genomic Imprinting.
Lee CC, Peng SH, Shen L, Lee CF, Du TH, Kang ML, Xu GL, Upadhyay AK, Cheng X, Yan YT, Zhang Y, Juan LJ., Free PMC Article | 10/21/2017 |
| NAA10 acts as a guard ensuring balanced osteogenesis by fine-tuning Runx2 signalling in a feedback manner. | NAA10 controls osteoblast differentiation and bone formation as a feedback regulator of Runx2.
Yoon H, Kim HL, Chun YS, Shin DH, Lee KH, Shin CS, Lee DY, Kim HH, Lee ZH, Ryoo HM, Lee MN, Oh GT, Park JW. | 02/27/2016 |
| ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. | Arrest defective 1 regulates the oxidative stress response in human cells and mice by acetylating methionine sulfoxide reductase A.
Shin SH, Yoon H, Chun YS, Shin HW, Lee MN, Oh GT, Park JW., Free PMC Article | 06/20/2015 |
| mARD1A(225) may be a novel upstream target that blocks VEGFA expression and tumor-related angiogenesis. | Roles of arrest-defective protein 1(225) and hypoxia-inducible factor 1alpha in tumor growth and metastasis.
Lee MN, Lee SN, Kim SH, Kim B, Jung BK, Seo JH, Park JH, Choi JH, Yim SH, Lee MR, Park JG, Yoo JY, Kim JH, Lee ST, Kim HM, Ryeom S, Kim KW, Oh GT., Free PMC Article | 04/12/2010 |
| Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase. | An evolutionarily conserved N-terminal acetyltransferase complex associated with neuronal development.
Sugiura N, Adams SM, Corriveau RA. | 01/21/2010 |
| Mouse ortholog (225) of ARD1 strongly decreased the level of hypoxia inducible factor (HIF)-1 alpha and increased the extent of acetylation, whereas mARD1(235) variants had a much weaker effect on HIF-1 alpha stability and acetylation. | Characterization of ARD1 variants in mammalian cells.
Kim SH, Park JA, Kim JH, Lee JW, Seo JH, Jung BK, Chun KH, Jeong JW, Bae MK, Kim KW. | 01/21/2010 |
| These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells. | Differential regulation of splicing, localization and stability of mammalian ARD1235 and ARD1225 isoforms.
Chun KH, Cho SJ, Choi JS, Kim SH, Kim KW, Lee SK. | 01/21/2010 |