| Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors. | Transcription factor PATZ1 promotes adipogenesis by controlling promoter regulatory loci of adipogenic factors.
Patel S, Ganbold K, Cho CH, Siddiqui J, Yildiz R, Sparman N, Sadeh S, Nguyen CM, Wang J, Whitelegge JP, Fried SK, Waki H, Villanueva CJ, Seldin MM, Sakaguchi S, Ellmeier W, Tontonoz P, Rajbhandari P., Free PMC Article | 10/9/2024 |
| Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells. | Complex Interplay Between MAZR and Runx3 Regulates the Generation of Cytotoxic T Lymphocyte and Memory T Cells.
Gülich AF, Rica R, Tizian C, Viczenczova C, Khamina K, Faux T, Hainberger D, Penz T, Bosselut R, Bock C, Laiho A, Elo LL, Bergthaler A, Ellmeier W, Sakaguchi S., Free PMC Article | 07/3/2021 |
| Structural analysis of the PATZ1 BTB domain homodimer. | Structural analysis of the PATZ1 BTB domain homodimer.
Piepoli S, Alt AO, Atilgan C, Mancini EJ, Erman B., Free PMC Article | 01/23/2021 |
| The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells. | The Transcription Factor MAZR/PATZ1 Regulates the Development of FOXP3(+) Regulatory T Cells.
Andersen L, Gülich AF, Alteneder M, Preglej T, Orola MJ, Dhele N, Stolz V, Schebesta A, Hamminger P, Hladik A, Floess S, Krausgruber T, Faux T, Andrabi SBA, Huehn J, Knapp S, Sparwasser T, Bock C, Laiho A, Elo LL, Rasool O, Lahesmaa R, Sakaguchi S, Ellmeier W. | 10/3/2020 |
| MAZR is an essential transcription factor regulating iNKT cell subset differentiation and effector function. | The zinc-finger transcription factor MAZR regulates iNKT cell subset differentiation.
Orola MJ, Tizian C, Zhu C, Andersen L, Gülich AF, Alteneder M, Stojakovic T, Wiedermann U, Trauner M, Ellmeier W, Sakaguchi S., Free PMC Article | 11/9/2019 |
| endothelial PATZ1 thus potently inhibits endothelial function and angiogenesis via inhibition of FABP4 expression, and abnormal induction of endothelial PATZ1 may contribute to multiple aspects of vascular dysfunction in diabetes | Hyperglycemia-induced PATZ1 negatively modulates endothelial vasculogenesis via repression of FABP4 signaling.
Chen RA, Sun XM, Yan CY, Liu L, Hao MW, Liu Q, Jiao XY, Liang YM. | 06/3/2017 |
| Together, these results suggest a novel mechanism regulating endothelial PATZ1 expression based on the down-regulation of miR-24 expression caused by hyperglycemia. Interfering with PATZ1 expression via miRNAs or miRNA mimics could potentially represent a new way to target endothelial PATZ1-dependent signaling of vascular dysfunction in diabetes. | miR-24 suppression of POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) protects endothelial cell from diabetic damage.
Cui YX, Hua YZ, Wang N, Chen X, Wang F, Liu JY, Wang LL, Yan CY, Ma YG, Cao YH, Zhang XH. | 06/3/2017 |
| the repression of ThPOK during CD8 lineage differentiation is mediated by the synergistic activity of the transcription factor MAZR and Runx/CBFbeta complexes. | MAZR and Runx Factors Synergistically Repress ThPOK during CD8+ T Cell Lineage Development.
Sakaguchi S, Hainberger D, Tizian C, Tanaka H, Okuda T, Taniuchi I, Ellmeier W. | 01/2/2016 |
| Results show that PATZ1 binds to p53 and inhibits p53-dependent transcription activation. | PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function.
Keskin N, Deniz E, Eryilmaz J, Un M, Batur T, Ersahin T, Cetin Atalay R, Sakaguchi S, Ellmeier W, Erman B., Free PMC Article | 07/25/2015 |
| The data support a PATZ1 tumour-suppressive function based on its ability to enhance p53-dependent transcription and apoptosis. | PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context.
Valentino T, Palmieri D, Vitiello M, Pierantoni GM, Fusco A, Fedele M., Free PMC Article | 06/14/2014 |
| analysis of embryos in which Patz1 was disrupted revealed the presence of severe defects in the CNS and in the cardiac outflow tract, which eventually lead to a pre-mature in utero death during late gestation or soon after birth | Embryonic defects and growth alteration in mice with homozygous disruption of the Patz1 gene.
Valentino T, Palmieri D, Vitiello M, Simeone A, Palma G, Arra C, Chieffi P, Chiariotti L, Fusco A, Fedele M. | 02/16/2013 |
| PATZ1 may have an important role in the regulation of EC senescence through an ROS-mediated p53-dependent pathway and contribute to vascular diseases associated with aging. | POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway.
Cho JH, Kim MJ, Kim KJ, Kim JR., Free PMC Article | 07/7/2012 |
| controls the CD4 versus CD8 lineage fate of double-positive thymocytes | The zinc-finger protein MAZR is part of the transcription factor network that controls the CD4 versus CD8 lineage fate of double-positive thymocytes.
Sakaguchi S, Hombauer M, Bilic I, Naoe Y, Schebesta A, Taniuchi I, Ellmeier W., Free PMC Article | 08/23/2010 |
| MAZR and MITF synergistically transactivated the mMCP-6 gene. MAZR appeared to play important roles in the normal phenotypic expression of mast cells in association with MITF | Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene.
Morii E, Oboki K, Kataoka TR, Igarashi K, Kitamura Y. | 01/21/2010 |
| results demonstrate epigenetic control of the Cd8 loci and identify MAZR as an important regulator of Cd8 expression | Negative regulation of CD8 expression via Cd8 enhancer-mediated recruitment of the zinc finger protein MAZR.
Bilic I, Koesters C, Unger B, Sekimata M, Hertweck A, Maschek R, Wilson CB, Ellmeier W., Free PMC Article | 01/21/2010 |