| Neuromedin U regulates the anti-tumor activity of CD8[+] T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner. | Neuromedin U regulates the anti-tumor activity of CD8(+) T cells and glycolysis of tumor cells in the tumor microenvironment of pancreatic ductal adenocarcinoma in an NMUR1-dependent manner.
Zheng R, Wang S, Wang J, Zhou M, Shi Q, Liu B., Free PMC Article | 02/16/2024 |
| Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine. | Neuromedin U programs eosinophils to promote mucosal immunity of the small intestine.
Li Y, Liu S, Zhou K, Wang Y, Chen Y, Hu W, Li S, Li H, Wang Y, Wang Q, He D, Xu H. | 09/18/2023 |
| Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection. | Neuromedin U Induces Pulmonary ILC2 Activation via the NMUR1 Pathway during Acute Respiratory Syncytial Virus Infection.
Liu W, Wang S, Wang J, Zheng R, Wang D, Yu R, Liu B. | 03/14/2023 |
| Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity. | Nmu/Nms/Gpr176 Triple-Deficient Mice Show Enhanced Light-Resetting of Circadian Locomotor Activity.
Yamaguchi Y, Murai I, Takeda M, Doi S, Seta T, Hanada R, Kangawa K, Okamura H, Miyake T, Doi M. | 08/6/2022 |
| Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents. | Brain region-specific neuromedin U signalling regulates alcohol-related behaviours and food intake in rodents.
Vallöf D, Kalafateli AL, Jerlhag E., Free PMC Article | 06/26/2021 |
| Neuromedin U (NMU) regulates osteoblast differentiation and activity. | Neuromedin U (NMU) regulates osteoblast differentiation and activity.
Hsiao YT, Jestes KJ, Jackson KL, Zukosky T, Squire ME, Hum JM, Lowery JW. | 10/24/2020 |
| Unlike NURP, icv injection of NMU significantly decreased the secretion of prolactin from the pituitary. NMU suppresses prolactin secretion via dopamine neurons of the arcuate nucleus | Neuromedin U suppresses prolactin secretion via dopamine neurons of the arcuate nucleus.
Nakahara K, Maruyama K, Ensho T, Mori K, Miyazato M, Kangawa K, Uemura R, Sakoda H, Nakazato M, Murakami N. | 08/1/2020 |
| These data indicate a novel role for the peripheral NMU system, providing new insights into the pathogenesis of NAFLD/NASH. | Role of neuromedin U in accelerating of non-alcoholic steatohepatitis in mice.
Teranishi H, Hayashi M, Higa R, Mori K, Miyazawa T, Hino J, Amano Y, Tozawa R, Ida T, Hanada T, Miyazato M, Hanada R, Kangawa K, Nakao K. | 08/4/2018 |
| Loss of NMU-NMUR1 signalling reduced ILC2 frequency and effector function, and altered transcriptional programs following allergen challenge in vivo. Thus, NMUR1 signalling promotes inflammatory ILC2 responses, highlighting the importance of neuro-immune crosstalk in allergic inflammation at mucosal surfaces. | The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.
Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK., Free PMC Article | 03/3/2018 |
| NMU treatment in vivo resulted in immediate protective type 2 responses; accordingly, group 2 innate lymphoid cells -autonomous ablation of Nmur1 led to impaired type 2 responses and poor control of worm infection | Neuronal regulation of type 2 innate lymphoid cells via neuromedin U.
Cardoso V, Chesné J, Ribeiro H, García-Cassani B, Carvalho T, Bouchery T, Shah K, Barbosa-Morais NL, Harris N, Veiga-Fernandes H., Free PMC Article | 02/10/2018 |
| data indicate that the NMU-NMUR1 neuronal signaling circuit provides a selective mechanism through which the enteric nervous system and innate immune system integrate to promote rapid type 2 cytokine responses that can induce anti-microbial, inflammatory and tissue-protective type 2 responses at mucosal sites | The neuropeptide neuromedin U stimulates innate lymphoid cells and type 2 inflammation.
Klose CSN, Mahlakõiv T, Moeller JB, Rankin LC, Flamar AL, Kabata H, Monticelli LA, Moriyama S, Putzel GG, Rakhilin N, Shen X, Kostenis E, König GM, Senda T, Carpenter D, Farber DL, Artis D., Free PMC Article | 02/10/2018 |
| These results suggested that NMU can act directly on beta cells through NMUR1 in an autocrine or paracrine fashion to suppress insulin secretion. Collectively, our results highlight the crucial role of NMU in suppressing pancreatic insulin secretion, and may improve our understanding of glucose homeostasis. | Neuromedin U suppresses glucose-stimulated insulin secretion in pancreatic β cells.
Zhang W, Sakoda H, Miura A, Shimizu K, Mori K, Miyazato M, Takayama K, Hayashi Y, Nakazato M. | 10/21/2017 |
| These results suggest that NMU and NMS are involved in thermoregulation via the prostaglandin E2 and beta3 adrenergic receptors, but that endogenous NMS might play a more predominant role than NMU. | Involvement of endogenous neuromedin U and neuromedin S in thermoregulation.
Nakahara K, Akagi A, Shimizu S, Tateno S, Qattali AW, Mori K, Miyazato M, Kangawa K, Murakami N. | 06/28/2016 |
| the anorectic effect of the lipidated NMU is partly mediated by a decrease in gastric emptying which is subject to tachyphylaxis after continuous dosing. | Neuromedin U inhibits food intake partly by inhibiting gastric emptying.
Dalbøge LS, Pedersen SL, Secher T, Holst B, Vrang N, Jelsing J. | 03/5/2016 |
| Beta-adrenergic and cholinergic mechanisms are involved in the anxiolytic action of neuromedin-U. | Anxiolytic action of neuromedin-U and neurotransmitters involved in mice.
Telegdy G, Adamik A. | 05/31/2014 |
| Data show that neuromedin U (NMU)-deficient mice developed less severe arthritis than control mice. | The neuropeptide neuromedin U promotes autoantibody-mediated arthritis.
Rao SM, Auger JL, Gaillard P, Weissleder R, Wada E, Torres R, Kojima M, Benoist C, Mathis D, Binstadt BA., Free PMC Article | 12/22/2012 |
| investigation of neuromedin U effects on factors associated with obesity/diabetes: NMU reduced food consumption/body weight; NMU increased body temperature/metabolic rate; NMU improved glucose tolerance; these effects seem to be mediated by NMUR1 | Effects of peripherally administered neuromedin U on energy and glucose homeostasis.
Peier AM, Desai K, Hubert J, Du X, Yang L, Qian Y, Kosinski JR, Metzger JM, Pocai A, Nawrocki AR, Langdon RB, Marsh DJ. | 09/3/2011 |
| negative regulator of bone formation through the molecular clock | Osteoporosis: a neuroskeletal disease?
Takeda S. | 01/21/2010 |
| proNMU(104-136) is a novel modulator of energy balance and may contribute to the phenotype exhibited by NMU knockout mice. | Appetite-modifying actions of pro-neuromedin U-derived peptides.
Bechtold DA, Ivanov TR, Luckman SM., Free PMC Article | 01/21/2010 |
| Central control of bone remodeling by Nmu is reported. | Central control of bone remodeling by neuromedin U.
Sato S, Hanada R, Kimura A, Abe T, Matsumoto T, Iwasaki M, Inose H, Ida T, Mieda M, Takeuchi Y, Fukumoto S, Fujita T, Kato S, Kangawa K, Kojima M, Shinomiya K, Takeda S. | 01/21/2010 |
| results suggest that endogenous NMU may be involved in reflexes and adaptation to environmental stimuli | Neuromedin U is involved in nociceptive reflexes and adaptation to environmental stimuli in mice.
Nakahara K, Kojima M, Hanada R, Egi Y, Ida T, Miyazato M, Kangawa K, Murakami N. | 01/21/2010 |
| NMU plays an important role in the regulation of feeding behavior and energy metabolism independent of the leptin signaling pathway. | Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway.
Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M. | 01/21/2010 |
| Analysis of NMU expression in ob/ob mice revealed elevated NMU mRNA levels in the dorsomedial hypothalamic (DMH) nucleus of ob/ob mice compared to lean litter-mates. NMU mRNA levels were elevated in the DMH of mice fasted for 24 h relative to controls | Neuromedin U and Neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status.
Graham ES, Turnbull Y, Fotheringham P, Nilaweera K, Mercer JG, Morgan PJ, Barrett P. | 01/21/2010 |
| data suggest that LPS-induced IL-6 expression is partly dependent on autocrine/paracrine activation of the NMU-NMU-R1 signals in macrophages | The neuropeptide neuromedin U promotes IL-6 production from macrophages and endotoxin shock.
Moriyama M, Matsukawa A, Kudoh S, Takahashi T, Sato T, Kano T, Yoshimura A, Kojima M. | 01/21/2010 |
| results indicate that NMU suppresses gonadotropin secretion and regulates the onset of puberty | Regulation of gonadotropin secretion and puberty onset by neuromedin U.
Fukue Y, Sato T, Teranishi H, Hanada R, Takahashi T, Nakashima Y, Kojima M. | 01/21/2010 |