| MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer. | MKK3 sustains cell proliferation and survival through p38DELTA MAPK activation in colorectal cancer.
Stramucci L, Pranteda A, Stravato A, Amoreo CA, Pennetti A, Diodoro MG, Bartolazzi A, Milella M, Bossi G., Free PMC Article | 08/29/2020 |
| p38delta promotes micro-aggregate transport by phosphorylating SQSTM1, a major scaffold protein that assembles soluble ubiquitylated proteins into micro-aggregates. | p38δ MAPK regulates aggresome biogenesis by phosphorylating SQSTM1 in response to proteasomal stress.
Zhang C, Gao J, Li M, Deng Y, Jiang C. | 10/26/2019 |
| Study identified p38alpha and p38delta as critical regulators of ASC oligomerization, inflammasome activation, and IL-1beta secretion in keratinocytes. Furthermore, data suggest that the nature of the mitogen-activated protein kinase regulating inflammasome activity exhibits a certain cell specificity, with p38 playing a predominant role in keratinocytes and Jun N-terminal kinase 1 in cells of myeloid origin. | The p38 Mitogen-Activated Protein Kinase Critically Regulates Human Keratinocyte Inflammasome Activation.
Fenini G, Grossi S, Gehrke S, Beer HD, Satoh TK, Contassot E, French LE. | 05/25/2019 |
| These observations indicate that p38alpha probably blocks brown adipose tissue thermogenesis through p38delta inhibition. | p38α blocks brown adipose tissue thermogenesis through p38δ inhibition.
Matesanz N, Nikolic I, Leiva M, Pulgarín-Alfaro M, Santamans AM, Bernardo E, Mora A, Herrera-Melle L, Rodríguez E, Beiroa D, Caballero A, Martín-García E, Acín-Pérez R, Hernández-Cosido L, Leiva-Vega L, Torres JL, Centeno F, Nebreda AR, Enríquez JA, Nogueiras R, Marcos M, Sabio G., Free PMC Article | 05/11/2019 |
| Mitogen-activated protein kinases p38gamma/p38delta deficiency protects against Candida albicans infection by increasing reactive oxygen species and iNOS enzyme production and thus the antifungal capacity of neutrophils and macrophages. | Myeloid cell deficiency of p38γ/p38δ protects against candidiasis and regulates antifungal immunity.
Alsina-Beauchamp D, Escós A, Fajardo P, González-Romero D, Díaz-Mora E, Risco A, Martín-Serrano MA, Del Fresno C, Dominguez-Andrés J, Aparicio N, Zur R, Shpiro N, Brown GD, Ardavín C, Netea MG, Alemany S, Sanz-Ezquerro JJ, Cuenda A., Free PMC Article | 03/30/2019 |
| The knockdown of MAPK13 also blocked the effect of miR23a5p in osteogenic differentiation of bone marrow-derived mesenchymal stem cells. | MicroRNA-23a-5p regulates osteogenic differentiation of human bone marrow-derived mesenchymal stem cells by targeting mitogen-activated protein kinase-13.
Ren G, Sun J, Li MM, Zhang YD, Li RH, Li YM. | 08/18/2018 |
| expression of claudin-11 in cutaneous squamous cell carcinoma cells depended on the activity of p38delta MAPK | Expression of claudin-11 by tumor cells in cutaneous squamous cell carcinoma is dependent on the activity of p38δ.
Nissinen L, Siljamäki E, Riihilä P, Piipponen M, Farshchian M, Kivisaari A, Kallajoki M, Raiko L, Peltonen J, Peltonen S, Kähäri VM. | 07/14/2018 |
| Study proposes MAPK p38delta protein as a key factor in breast cancer. | P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment.
Wada M, Canals D, Adada M, Coant N, Salama MF, Helke KL, Arthur JS, Shroyer KR, Kitatani K, Obeid LM, Hannun YA., Free PMC Article | 12/9/2017 |
| The p38delta mitogen-activated protein kinase was identified as a novel regulator of NLRP3 inflammasome activation in primary human macrophages, and thus, represents a potential target for modulation of atherosclerotic inflammation. | p38δ MAPK: A Novel Regulator of NLRP3 Inflammasome Activation With Increased Expression in Coronary Atherogenesis.
Rajamäki K, Mäyränpää MI, Risco A, Tuimala J, Nurmi K, Cuenda A, Eklund KK, Öörni K, Kovanen PT. | 06/24/2017 |
| p38delta expression was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. No significant association was found for p38delta between its expression and other clinicopathological parameters. In Eca109 cells, p38delta can promote the cell growth and motility. p38delta overexpression promotes tumorigenesis in nude mice when p38delta was stably over-expressed and p38ga... | Clinicopathological significance of p38β, p38γ, and p38δ and its biological roles in esophageal squamous cell carcinoma.
Zheng S, Yang C, Liu T, Liu Q, Dai F, Sheyhidin I, Lu X. | 02/18/2017 |
| MAPK13 gene knockdown using siRNA reduced the aldehyde dehydrogenase high cell population and abrogated the tumor-initiating ability. | MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation.
Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, Tsukahara T, Hasegawa T, Saito T, Sato N, Torigoe T. | 08/13/2016 |
| p38gamma and p38delta reprogram liver metabolism by modulating neutrophil infiltration and provide a potential target for NAFLD therapy | p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration.
González-Terán B, Matesanz N, Nikolic I, Verdugo MA, Sreeramkumar V, Hernández-Cosido L, Mora A, Crainiciuc G, Sáiz ML, Bernardo E, Leiva-Vega L, Rodríguez E, Bondía V, Torres JL, Perez-Sieira S, Ortega L, Cuenda A, Sanchez-Madrid F, Nogueiras R, Hidalgo A, Marcos M, Sabio G., Free PMC Article | 07/30/2016 |
| MAPK13 undergoes a larger interlobe configurational rearrangement upon activation compared with MAPK14. | The crystal structure of phosphorylated MAPK13 reveals common structural features and differences in p38 MAPK family activation.
Yurtsever Z, Scheaffer SM, Romero AG, Holtzman MJ, Brett TJ., Free PMC Article | 01/16/2016 |
| PKCdelta activates a MEKK1/MEK3/p38delta MAPK cascade to increase p53 levels and p53 drives p21(Cip1) gene expression. | p38δ regulates p53 to control p21Cip1 expression in human epidermal keratinocytes.
Saha K, Adhikary G, Kanade SR, Rorke EA, Eckert RL., Free PMC Article | 06/7/2014 |
| esophageal squamous cell carcinoma cell lines which are p38delta-negative grew more quickly than cell lines which express endogenous p38delta. | Loss of p38δ mitogen-activated protein kinase expression promotes oesophageal squamous cell carcinoma proliferation, migration and anchorage-independent growth.
O'Callaghan C, Fanning LJ, Houston A, Barry OP., Free PMC Article | 03/22/2014 |
| DNA methylation alterations are widespread in melanoma; epigenetic silencing of MAPK13 contributes to melanoma progression | Genome-wide promoter methylation analysis identifies epigenetic silencing of MAPK13 in primary cutaneous melanoma.
Gao L, Smit MA, van den Oord JJ, Goeman JJ, Verdegaal EM, van der Burg SH, Stas M, Beck S, Gruis NA, Tensen CP, Willemze R, Peeper DS, van Doorn R. | 02/8/2014 |
| Data indicate that p38delta mediates oncogene-induced senescence through a p53- and p16(INK4A)-independent mechanism. | Induction of p38δ expression plays an essential role in oncogenic ras-induced senescence.
Kwong J, Chen M, Lv D, Luo N, Su W, Xiang R, Sun P., Free PMC Article | 11/30/2013 |
| GSK3alpha, GSK3beta, and MAPK13 were found to be the most active tau kinases, phosphorylating tau at all four epitopes. | An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.
Cavallini A, Brewerton S, Bell A, Sargent S, Glover S, Hardy C, Moore R, Calley J, Ramachandran D, Poidinger M, Karran E, Davies P, Hutton M, Szekeres P, Bose S., Free PMC Article | 11/2/2013 |
| MAPK13 is responsible for IL-13-driven mucus production in human airway epithelial cells. | IL-13-induced airway mucus production is attenuated by MAPK13 inhibition.
Alevy YG, Patel AC, Romero AG, Patel DA, Tucker J, Roswit WT, Miller CA, Heier RF, Byers DE, Brett TJ, Holtzman MJ., Free PMC Article | 02/9/2013 |
| SEPW1 silencing increases MKK4, which activates p38gamma, p38delta, and JNK2 to phosphorylate p53 on Ser-33 and cause a transient G(1) arrest. | Delayed cell cycle progression in selenoprotein W-depleted cells is regulated by a mitogen-activated protein kinase kinase 4-p38/c-Jun NH2-terminal kinase-p53 pathway.
Hawkes WC, Alkan Z., Free PMC Article | 11/17/2012 |
| PRMT5 inhibits the PKCdelta- or 12-O-tetradecanoylphorbol-13-acetate-dependent increase in human involucrin expression, and PRMT5 dimethylates proteins in the p38delta complex. | Protein arginine methyltransferase 5 (PRMT5) signaling suppresses protein kinase Cδ- and p38δ-dependent signaling and keratinocyte differentiation.
Kanade SR, Eckert RL., Free PMC Article | 04/28/2012 |
| Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D. | Isoforms of p38MAPK gamma and delta contribute to differentiation of human AML cells induced by 1,25-dihydroxyvitamin D₃.
Zhang J, Harrison JS, Studzinski GP., Free PMC Article | 01/1/2011 |
| Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator) | Genetic variants within the MAP kinase signalling network and anti-TNF treatment response in rheumatoid arthritis patients.
Coulthard LR, Taylor JC, Eyre S, Biologics in Rheumatoid Arthritis Genetics and Genomics, Robinson JI, Wilson AG, Isaacs JD, Hyrich K, Emery P, Barton A, Barrett JH, Morgan AW, McDermott MF. | 12/5/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD, ASCOT investigators, NORDIL investigators, BRIGHT Consortium., Free PMC Article | 09/15/2010 |
| Taken together, the data indicate that the respective stress-dependent action of p38 isoforms is responsible for the up-regulation of the gene expression of the chemokine BRAK/CXCL14. | Human p38 delta MAP kinase mediates UV irradiation induced up-regulation of the gene expression of chemokine BRAK/CXCL14.
Ozawa S, Ito S, Kato Y, Kubota E, Hata R. | 07/19/2010 |