| The expression of YWHAB was upregulated by oleic acid in a concentrationdependent manner in vascular smooth muscle cells. | Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids.
Feng L, Dou C, Wang J, Jiang C, Ma X, Liu J. | 10/13/2018 |
| The results indicate that hyperglycemia-induced up-regulation of YWHAB in endothelial cell plays a significant role in intimal hyperplasia following carotid artery injury by enhancing endothelial cell proliferation and migration. | Up-regulation of 14-3-3β plays a role in intimal hyperplasia following carotid artery injury in diabetic Sprague Dawley rats by promoting endothelial cell migration and proliferation.
Feng L, Ma X, Wang J, Tian Q. | 09/23/2017 |
| This study reveals that 14-3-3 gamma protein is present in oligodendroglial cells and that 14-3-3 gamma deficiency leads to more severe chronic EAE with enhanced demyelination. | Role of glial 14-3-3 gamma protein in autoimmune demyelination.
Lee DH, Steinacker P, Seubert S, Turnescu T, Melms A, Manzel A, Otto M, Linker RA., Free PMC Article | 06/28/2016 |
| PKC-mediated KCNK3 internalization required the presence of both 14-3-3beta and a novel potassium channel endocytic motif | The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3β-dependent, protein kinase C (PKC)-mediated endocytic trafficking.
Gabriel L, Lvov A, Orthodoxou D, Rittenhouse AR, Kobertz WR, Melikian HE., Free PMC Article | 12/8/2012 |
| Results showed that sepsis alters the expression of 14-3-3 beta isoform in a time-, cell-, and topography-dependent manner, with the choroid plexus showed constantly increased beta isoform expression. | Alternations of 14-3-3 θ and β protein levels in brain during experimental sepsis.
Memos N, Kataki A, Chatziganni E, Nikolopoulou M, Skoulakis E, Consoulas C, Zografos G, Konstadoulakis M. | 12/10/2011 |
| Results indicate that the phosphorylation-dependent interaction between 14-3-3beta and alphaII spectrin acts as a switch between positive and negative regulation of neurite outgrowth stimulated by NCAM. | Binding of alphaII spectrin to 14-3-3beta is involved in NCAM-dependent neurite outgrowth.
Ramser EM, Buck F, Schachner M, Tilling T. | 11/6/2010 |
| individual subdomains in the GSM (MCR I through V) play diverse but crucial roles in cooperation with essential trans-acting cofactors such as 14-3-3 proteins to mediate the glucose response of ChREBP | Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3.
Li MV, Chen W, Poungvarin N, Imamura M, Chan L., Free PMC Article | 01/21/2010 |
| FBI1 and 14-3-3beta were presented on the MKP-1 promoter. These results indicate that FBI1 promotes sustained ERK1/2 activation through repression of MKP-1 transcription, resulting in promotion of tumorigenicity and metastasis. | A novel binding factor of 14-3-3beta functions as a transcriptional repressor and promotes anchorage-independent growth, tumorigenicity, and metastasis.
Komiya Y, Kurabe N, Katagiri K, Ogawa M, Sugiyama A, Kawasaki Y, Tashiro F. | 01/21/2010 |
| Data suggest the presence of 14-3-3zeta within CSF may be a biomarker of acute seizure damage. | Detection of 14-3-3zeta in cerebrospinal fluid following experimentally evoked seizures.
Murphy N, Yamamoto A, Henshall DC. | 01/21/2010 |
| Kainic acid evoked seizures triggered Bid protein cleavage and a commensurate increase in binding of Bid to 14-3-3 within injured hippocampus suggesting 14-3-3 proteins may target active and inactive conformations of pro-apoptotic Bcl-2 death agonists | Interaction of 14-3-3 with Bid during seizure-induced neuronal death.
Shinoda S, Schindler CK, Quan-Lan J, Saugstad JA, Taki W, Simon RP, Henshall DC. | 01/21/2010 |
| mechanism of CaM kinase IIdeltaC silencing of MEF-2-dependent genes is by phosphorylation of 14-3-3beta, which allows HDAC to return to the nucleus to reform a complex with MEF2, thereby silencing MADS box-dependent gene induction in smooth muscle | CaM kinase IIdeltaC phosphorylation of 14-3-3beta in vascular smooth muscle cells: activation of class II HDAC repression.
Ellis JJ, Valencia TG, Zeng H, Roberts LD, Deaton RA, Grant SR. | 01/21/2010 |
| 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity | 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.
Cavet ME, Lehoux S, Berk BC. | 01/21/2010 |