| JNK2 Promotes Progression of Esophageal Squamous Cell Carcinoma via Inhibiting Axin2. | JNK2 Promotes Progression of Esophageal Squamous Cell Carcinoma via Inhibiting Axin2.
Wang L, Guo M, Gao L, Liu K, Bai J, Liu Z. | 01/7/2024 |
| c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1. | c-Jun N-terminal kinase 2 suppresses pancreatic cancer growth and invasion and is opposed by c-Jun N-terminal kinase 1.
Tian X, Traub B, Shi J, Huber N, Schreiner S, Chen G, Zhou S, Henne-Bruns D, Knippschild U, Kornmann M., Free PMC Article | 04/9/2022 |
| c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease. | c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.
Smith AO, Jonassen JA, Preval KM, Davis RJ, Pazour GJ., Free PMC Article | 02/19/2022 |
| miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury. | miR-221-5p-Mediated Downregulation of JNK2 Aggravates Acute Lung Injury.
Yang J, Do-Umehara HC, Zhang Q, Wang H, Hou C, Dong H, Perez EA, Sala MA, Anekalla KR, Walter JM, Liu S, Wunderink RG, Budinger GRS, Liu J., Free PMC Article | 02/12/2022 |
| The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases. | The Roles of c-Jun N-Terminal Kinase (JNK) in Infectious Diseases.
Chen J, Ye C, Wan C, Li G, Peng L, Peng Y, Fang R., Free PMC Article | 10/30/2021 |
| JNK2 activity is specifically required for melanoma cell proliferation, invasiveness. | JNK2 Is Required for the Tumorigenic Properties of Melanoma Cells.
Du L, Anderson A, Nguyen K, Ojeda SS, Ortiz-Rivera I, Nguyen TN, Zhang T, Kaoud TS, Gray NS, Dalby KN, Tsai KY., Free PMC Article | 01/4/2020 |
| Polymorphisms in MAPK9 (rs4147385) and CSF1R (rs17725712) are associated with the development of inhibitors in patients with haemophilia A. | Polymorphisms in MAPK9 (rs4147385) and CSF1R (rs17725712) are associated with the development of inhibitors in patients with haemophilia A in North China.
Zhao M, Zhang Y, Liu Y, Sun G, Tian H, Hong L. | 12/14/2019 |
| JNK2 activation up-regulates CaMKIIdelta expression in the aged atrium and may promote the occurrence of cardiac arrhythmias. | Transcriptional regulation of stress kinase JNK2 in pro-arrhythmic CaMKIIδ expression in the aged atrium.
Gao X, Wu X, Yan J, Zhang J, Zhao W, DeMarco D, Zhang Y, Bakhos M, Mignery G, Sun J, Li Z, Fill M, Ai X., Free PMC Article | 08/3/2019 |
| Binge alcohol drinking activates JNK2 kinase in heart, triggering atrial arrhythmia. | Role of Stress Kinase JNK in Binge Alcohol-Evoked Atrial Arrhythmia.
Yan J, Thomson JK, Zhao W, Gao X, Huang F, Chen B, Liang Q, Song LS, Fill M, Ai X., Free PMC Article | 07/27/2019 |
| JNK2 has the function of enhancing the proliferation and anti-apoptotic ability of SCL-1 human cutaneous squamous cell carcinoma cells. | [Overexpression of JNK2 enhances proliferation and anti-apoptotic ability of SCL-1 human cutaneous squamous cell carcinoma cells].
Liu H, Dong H, Zhang X, Chen Y, Jiao Y, Ge X. | 07/20/2019 |
| Study reports that JNK1/2 activities attenuate LKB1-deficiency-driven lung squamous cell carcinoma (LSCC) initiation and progression through repressing DeltaNp63 signaling. LSCC patients with higher JNK1/2 activities have better survival rates and activating JNK1/2 activities attenuate LSCC progression. | JNK(1/2) represses Lkb(1)-deficiency-induced lung squamous cell carcinoma progression.
Liu J, Wang T, Creighton CJ, Wu SP, Ray M, Janardhan KS, Willson CJ, Cho SN, Castro PD, Ittmann MM, Li JL, Davis RJ, DeMayo FJ., Free PMC Article | 07/6/2019 |
| As levels of intracellular H2O2 rise, a switch occurs from activation to inhibition of JNK2 activity, linking JNK2 regulation to the redox status of the cell. | H(2)O(2) oxidation of cysteine residues in c-Jun N-terminal kinase 2 (JNK2) contributes to redox regulation in human articular chondrocytes.
Nelson KJ, Bolduc JA, Wu H, Collins JA, Burke EA, Reisz JA, Klomsiri C, Wood ST, Yammani RR, Poole LB, Furdui CM, Loeser RF., Free PMC Article | 03/23/2019 |
| results revealed that melatonin attenuated chemokine CCL24 levels through inhibition of the JNK pathway to hinder human osteosarcoma cell invasion, thereby highlighting the therapeutic potential of melatonin for osteosarcoma metastasis. | Melatonin attenuates osteosarcoma cell invasion by suppression of C-C motif chemokine ligand 24 through inhibition of the c-Jun N-terminal kinase pathway.
Lu KH, Su SC, Lin CW, Hsieh YH, Lin YC, Chien MH, Reiter RJ, Yang SF. | 12/22/2018 |
| HMBG2 overexpression promotes ischemia/reperfusion-induced cell apoptosis through activating the JNK1/2-NF-kappaBp65 signaling in AC16 cardiomyocytes. | Involvement of JNK1/2-NF-κBp65 in the regulation of HMGB2 in myocardial ischemia/reperfusion-induced apoptosis in human AC16 cardiomyocytes.
Zhang W, Zhang Y, Ding K, Zhang H, Zhao Q, Liu Z, Xu Y. | 12/1/2018 |
| Taken together, the silencing of H4R inhibited the H4R mediated Mast cell functions and SAPK/JNK phosphorylation. Furthermore, the H4R activation utilized SAPK/JNK signaling pathway for IL-1beta release in HMC-1 cells. | Silencing of H4R inhibits the production of IL-1β through SAPK/JNK signaling in human mast cells.
Ebenezer AJ, Prasad K, Rajan S, Thangam EB. | 10/27/2018 |
| RhoGDIbeta overexpression led to downregulation of miR-200c, whereas miR-200c was able directly to target 3'-UTR of jnk2mRNA and attenuated JNK2 protein translation, which resulted in attenuation of Sp1mRNA and protein expression in turn, inhibiting Sp1-dependent MMP-2 transcription. | RhoGDIβ promotes Sp1/MMP-2 expression and bladder cancer invasion through perturbing miR-200c-targeted JNK2 protein translation.
Huang H, Jin H, Zhao H, Wang J, Li X, Yan H, Wang S, Guo X, Xue L, Li J, Peng M, Wang A, Zhu J, Wu XR, Chen C, Huang C., Free PMC Article | 06/23/2018 |
| The MAP kinase JNK2 mediates cigarette smoke-induced tissue factor activation, arterial thrombosis and reactive oxygen species production. | The MAP kinase JNK2 mediates cigarette smoke-induced arterial thrombosis.
Breitenstein A, Stämpfli SF, Reiner MF, Shi Y, Keller S, Akhmedov A, Schaub Clerigué A, Spescha RD, Beer HJ, Lüscher TF, Tanner FC, Camici GG. | 03/3/2018 |
| these data provide new evidence for an indispensable role for JNK/SAPK signaling to overcome the well-established molecular barriers in human somatic cell induced reprogramming. | JNK/SAPK Signaling Is Essential for Efficient Reprogramming of Human Fibroblasts to Induced Pluripotent Stem Cells.
Neganova I, Shmeleva E, Munkley J, Chichagova V, Anyfantis G, Anderson R, Passos J, Elliott DJ, Armstrong L, Lako M., Free PMC Article | 12/9/2017 |
| We found p-JNK2 up-regulation in AUC and its early down-regulation in UC-CRC and CRC carcinogenesis. | Inactivation of JNK2 as carcinogenic factor in colitis-associated and sporadic colorectal carcinogenesis.
Lessel W, Silver A, Jechorek D, Guenther T, Roehl FW, Kalinski T, Roessner A, Poehlmann-Nitsche A. | 09/9/2017 |
| JNK2 was a novel direct target of miR-20a-5p. | Down-regulation of miR-20a-5p triggers cell apoptosis to facilitate mycobacterial clearance through targeting JNK2 in human macrophages.
Zhang G, Liu X, Wang W, Cai Y, Li S, Chen Q, Liao M, Zhang M, Zeng G, Zhou B, Feng CG, Chen X., Free PMC Article | 06/24/2017 |
| The release of infectious respiratory syncytial virus (RSV) virions from infected cells was significantly reduced by JNK1/2 siRNA knockdown, implicating JNK1/2 as a key host factor for RSV virus production. | c-Jun N-terminal kinase activity is required for efficient respiratory syncytial virus production.
Caly L, Li HM, Bogoyevitch MA, Jans DA. | 06/10/2017 |
| PXR regulates the intestinal epithelial barrier during inflammation by modulating cytokine-induced MLCK expression and JNK1/2 activation | Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.
Garg A, Zhao A, Erickson SL, Mukherjee S, Lau AJ, Alston L, Chang TK, Mani S, Hirota SA., Free PMC Article | 05/27/2017 |
| Phloretin is able to inhibit NSCLC A549 cell growth by inducing apoptosis through P38 MAPK and JNK1/2 pathways, and therefore may prove to be an adjuvant to the treatment of non-small cell lung cancer | Phloretin induces apoptosis of non-small cell lung carcinoma A549 cells via JNK1/2 and p38 MAPK pathways.
Min J, Huang K, Tang H, Ding X, Qi C, Qin X, Xu Z., Free PMC Article | 08/13/2016 |
| In hepatocytes, JNK1 and JNK2 appear to have combined effects in protecting from drug-induced liver injury. | Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.
Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C., Free PMC Article | 08/13/2016 |
| Inhibition of JNK1/2 activity suppressed Hedgehog pathway activity in acquired chemoresistant cancer cells. | JNK is required for maintaining the tumor-initiating cell-like properties of acquired chemoresistant human cancer cells.
Liu Y, Zhang X, Wang J, Yang J, Tan WF., Free PMC Article | 07/30/2016 |