| Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration. | Deletion of IFT20 exclusively in the RPE ablates primary cilia and leads to retinal degeneration.
Kretschmer V, Schneider S, Matthiessen PA, Reichert D, Hotaling N, Glasßer G, Lieberwirth I, Bharti K, De Cegli R, Conte I, Nandrot EF, May-Simera HL., Free PMC Article | 12/18/2023 |
| Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4[+] T cells. | Regulation of c-SMAC formation and AKT-mTOR signaling by the TSG101-IFT20 axis in CD4(+) T cells.
Jeong J, Kang I, Kim Y, Ku KB, Park JH, Kim HJ, Kim CW, La J, Jung HE, Kim HC, Choi YJ, Kim J, Kim J, Lee HK., Free PMC Article | 05/25/2023 |
| Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice. | Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice.
Yamaguchi H, Kitami M, Uchima Koecklin KH, He L, Wang J, Lagor WR, Perrien DS, Komatsu Y. | 02/12/2022 |
| An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration. | An IFT20 mechanotrafficking axis is required for integrin recycling, focal adhesion dynamics, and polarized cell migration.
Su S, Begum S, Ezratty EJ., Free PMC Article | 06/12/2021 |
| IFT20 is critical for collagen biosynthesis in craniofacial bone formation. | IFT20 is critical for collagen biosynthesis in craniofacial bone formation.
Yamaguchi H, Terajima M, Kitami M, Wang J, He L, Saeki M, Yamauchi M, Komatsu Y., Free PMC Article | 03/20/2021 |
| Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein. | Mouse spermatogenesis-associated protein 1 (SPATA1), an IFT20 binding partner, is an acrosomal protein.
Zhang L, Zhen J, Huang Q, Liu H, Li W, Zhang S, Min J, Li Y, Shi L, Woods J, Chen X, Shi Y, Liu Y, Hess RA, Song S, Zhang Z., Free PMC Article | 01/9/2021 |
| These results reveal that IFT20 regulates polarity and cell alignment via ceramide-pPKCzeta-beta-catenin signaling during bone development. | Primary cilia control cell alignment and patterning in bone development via ceramide-PKCζ-β-catenin signaling.
Lim J, Li X, Yuan X, Yang S, Han L, Yang S., Free PMC Article | 06/13/2020 |
| GMAP210 is essential for acrosome biogenesis, normal mitochondrial sheath formation, and male fertility, and it determines expression levels and acrosomal localization of IFT20 and other acrosomal proteins. | Abnormal fertility, acrosome formation, IFT20 expression and localization in conditional Gmap210 knockout mice.
Wang Z, Shi Y, Ma S, Huang Q, Yap YT, Shi L, Zhang S, Zhou T, Li W, Hu B, Zhang L, Krawetz SA, Pazour GJ, Hess RA, Zhang Z., Free PMC Article | 05/9/2020 |
| IFT20 is required for ciliary-dependent Hedgehog signaling to produce cartilaginous matrix in condylar cartilage. | IFT20 is required for the maintenance of cartilaginous matrix in condylar cartilage.
Kitami M, Yamaguchi H, Ebina M, Kaku M, Chen D, Komatsu Y., Free PMC Article | 10/12/2019 |
| Authors showed that in chondrocytes from human (ACH, TD) and mouse Fgfr3Y367C/+ cartilage, the constitutively active FGFR3 perturbed PC length and the sorting and trafficking of intraflagellar transport (IFT) 20 to the PC. | Constitutively-active FGFR3 disrupts primary cilium length and IFT20 trafficking in various chondrocyte models of achondroplasia.
Martin L, Kaci N, Estibals V, Goudin N, Garfa-Traore M, Benoist-Lasselin C, Dambroise E, Legeai-Mallet L. | 01/5/2019 |
| intraflagellar transport protein 20 (IFT20) interacts with E3 ubiquitin ligases c-Cbl and Cbl-b and is required for Cbl-mediated ubiquitination and internalization of PDGFRalpha for feedback inhibition of receptor signaling. | IFT20 modulates ciliary PDGFRα signaling by regulating the stability of Cbl E3 ubiquitin ligases.
Schmid FM, Schou KB, Vilhelm MJ, Holm MS, Breslin L, Farinelli P, Larsen LA, Andersen JS, Pedersen LB, Christensen ST., Free PMC Article | 11/3/2018 |
| IFT20 is required for the delivery of the intracellular pool of LAT to the immune synapse in naive primary T lymphocytes. | IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo.
Vivar OI, Masi G, Carpier JM, Magalhaes JG, Galgano D, Pazour GJ, Amigorena S, Hivroz C, Baldari CT., Free PMC Article | 06/28/2016 |
| Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea. | Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea.
May-Simera HL, Petralia RS, Montcouquiol M, Wang YX, Szarama KB, Liu Y, Lin W, Deans MR, Pazour GJ, Kelley MW., Free PMC Article | 03/21/2015 |
| This work is a strong support of a model of opsin transport where IFT20 is involved in the movement from the Golgi complex to the base of the cilium | Distinct functions for IFT140 and IFT20 in opsin transport.
Crouse JA, Lopes VS, Sanagustin JT, Keady BT, Williams DS, Pazour GJ., Free PMC Article | 01/3/2015 |
| Mxi1 regulates Ift20 promoter activity via Ets-1 binding to the Ift20 promoter. These results indicate that inactivating Mxi1 induces ciliary defects in polycystic kidney. | Inactivation of max-interacting protein 1 induces renal cilia disassembly through reduction in levels of intraflagellar transport 20 in polycystic kidney.
Ko JY, Yoo KH, Song SA, Kim DY, Kong HK, Ahn C, Lee HW, Kang DH, Oh GT, Park JH., Free PMC Article | 05/11/2013 |
| Data show that loss of IFT20 during cone development leads to opsin accumulation in the inner segment even when the connecting cilium and outer segment are still intact. | IFT20 is required for opsin trafficking and photoreceptor outer segment development.
Keady BT, Le YZ, Pazour GJ., Free PMC Article | 12/10/2011 |
| An interaction between SPEF2 and the intraflagellar transport protein IFT20 in the testis. | Expression of SPEF2 during mouse spermatogenesis and identification of IFT20 as an interacting protein.
Sironen A, Hansen J, Thomsen B, Andersson M, Vilkki J, Toppari J, Kotaja N. | 06/14/2010 |
| IFT20 is the only complex B protein that localizes to the Golgi apparatus. | Characterization of mouse IFT complex B.
Follit JA, Xu F, Keady BT, Pazour GJ., Free PMC Article | 01/21/2010 |
| GMAP210 and IFT20 function together at the Golgi in the sorting of proteins destined for the ciliary membrane. | The Golgin GMAP210/TRIP11 anchors IFT20 to the Golgi complex.
Follit JA, San Agustin JT, Xu F, Jonassen JA, Samtani R, Lo CW, Pazour GJ., Free PMC Article | 01/21/2010 |
| IFT20 functions to couple extracellular events to cell proliferation and differentiation and deletion results in cystic kidney diseease. | Deletion of IFT20 in the mouse kidney causes misorientation of the mitotic spindle and cystic kidney disease.
Jonassen JA, San Agustin J, Follit JA, Pazour GJ., Free PMC Article | 01/21/2010 |
| This work suggests that IFT20 functions in the delivery of ciliary membrane proteins from the Golgi complex to the cilium. | The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly.
Follit JA, Tuft RA, Fogarty KE, Pazour GJ., Free PMC Article | 01/21/2010 |