| Abscisic acid signaling through LANCL2 and PPARgamma induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells. | Abscisic acid signaling through LANCL2 and PPARγ induces activation of p38MAPK resulting in dormancy of prostate cancer metastatic cells.
Parajuli KR, Jung Y, Taichman RS., Free PMC Article | 04/22/2024 |
| Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients. | Identification of prognostic values defined by copy number variation, mRNA and protein expression of LANCL2 and EGFR in glioblastoma patients.
Zhao HF, Zhou XM, Wang J, Chen FF, Wu CP, Diao PY, Cai LR, Chen L, Xu YW, Liu J, Li ZY, Liu WL, Chen ZP, Huang GD, Li WP., Free PMC Article | 09/18/2021 |
| Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis. | Akt kinase LANCL2 functions as a key driver in EGFR-mutant lung adenocarcinoma tumorigenesis.
Lou Y, Xu J, Zhang Y, Zhang W, Zhang X, Gu P, Zhong H, Wang H, Lu J, Han B., Free PMC Article | 09/18/2021 |
| Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle. | Abscisic acid enriched fig extract promotes insulin sensitivity by decreasing systemic inflammation and activating LANCL2 in skeletal muscle.
Leber A, Hontecillas R, Tubau-Juni N, Zoccoli-Rodriguez V, Goodpaster B, Bassaganya-Riera J., Free PMC Article | 12/12/2020 |
| Site-directed mutagenesis (single mutant R118I, triple mutants R118I/R22I/K362I and R118I/S41A/E46I) and equilibrium binding experiments on the mutated LANCL2 proteins identified a high-affinity ABA-binding site involving R118, with a KD of 2.6nM+/-1.2nM, as determined by surface plasmon resonance. | Identification of a high affinity binding site for abscisic acid on human lanthionine synthetase component C-like protein 2.
Cichero E, Fresia C, Guida L, Booz V, Millo E, Scotti C, Iamele L, de Jonge H, Galante D, De Flora A, Sturla L, Vigliarolo T, Zocchi E, Fossa P. | 01/19/2019 |
| human LANCL2 is a non-transmembrane G protein-coupled receptor susceptible to hormone-induced nuclear translocation. | G-protein coupling and nuclear translocation of the human abscisic acid receptor LANCL2.
Fresia C, Vigliarolo T, Guida L, Booz V, Bruzzone S, Sturla L, Di Bona M, Pesce M, Usai C, De Flora A, Zocchi E., Free PMC Article | 04/7/2018 |
| Data indicate that lanthionine synthetase C-like 2 (LanCL2) depletion sensitizes cells to apoptosis through down-regulating serine/threonine protein kinase Akt phosphorylation. | Lanthionine synthetase C-like protein 2 (LanCL2) is a novel regulator of Akt.
Zeng M, van der Donk WA, Chen J., Free PMC Article | 08/1/2015 |
| human recombinant LANCL2 binds abscisic acid (ABA) directly and provide the first demonstration of ABA binding to a mammalian ABA receptor. | Binding of abscisic acid to human LANCL2.
Sturla L, Fresia C, Guida L, Grozio A, Vigliarolo T, Mannino E, Millo E, Bagnasco L, Bruzzone S, De Flora A, Zocchi E. | 01/21/2012 |
| Molecular docking studies predict that ABA and other PPAR gamma agonists (e.g., rosiglitazone and pioglitazone) share a binding site on the surface of LANCL2. | Molecular modeling of lanthionine synthetase component C-like protein 2: a potential target for the discovery of novel type 2 diabetes prophylactics and therapeutics.
Lu P, Bevan DR, Lewis SN, Hontecillas R, Bassaganya-Riera J. | 07/9/2011 |
| Data show that lanthionine synthetase C-like protein (LANCL2) is required for abscisic acid binding on human granulocyte membranes and that LANCL2 is necessary for transduction of the ABA signal into granulocytes and rat insulinoma cells. | LANCL2 is necessary for abscisic acid binding and signaling in human granulocytes and in rat insulinoma cells.
Sturla L, Fresia C, Guida L, Bruzzone S, Scarfì S, Usai C, Fruscione F, Magnone M, Millo E, Basile G, Grozio A, Jacchetti E, Allegretti M, De Flora A, Zocchi E., Free PMC Article | 01/21/2010 |
| Using shotgun mass spectrometry, we found this protein differentially expressed in the dorsolateral prefrontal cortex from patients with schizophrenia. | Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.
Martins-de-Souza D, Gattaz WF, Schmitt A, Rewerts C, Maccarrone G, Dias-Neto E, Turck CW. | 01/28/2009 |
| Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism. | Lanthionine synthetase components C-like 2 increases cellular sensitivity to adriamycin by decreasing the expression of P-glycoprotein through a transcription-mediated mechanism.
Park S, James CD. | 01/21/2010 |
| cDNA cloned and characterized. May play a role as a component of a peptide-modifying complex | Molecular cloning, characterization, and tissue-specific expression of human LANCL2, a novel member of the LanC-like protein family.
Mayer H, Pongratz M, Prohaska R. | 01/21/2010 |