| Optimization of CFTR gating through the evolution of its extracellular loops. | Optimization of CFTR gating through the evolution of its extracellular loops.
Simon MA, Csanády L., Free PMC Article | 02/11/2023 |
| Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis. | Cystic fibrosis transmembrane conductance regulator (CFTR) regulates embryonic organizer formation during zebrafish early embryogenesis.
Liu Y, Lin Z, Sun H. | 10/16/2021 |
| CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy. | CFTR deficiency causes cardiac dysplasia during zebrafish embryogenesis and is associated with dilated cardiomyopathy.
Liu Y, Lin Z, Liu M, Liao H, Chen Y, Zhang X, Chan HC, Zhou B, Rao L, Sun H. | 08/14/2021 |
| CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model. | CFTR Depletion Confers Hypersusceptibility to Mycobacterium fortuitum in a Zebrafish Model.
Johansen MD, Kremer L., Free PMC Article | 06/26/2021 |
| Findings highlight the crucial and specific role of CFTR in the immune control of M. abscessus by mounting effective oxidative responses. | CFTR Protects against Mycobacterium abscessus Infection by Fine-Tuning Host Oxidative Defenses.
Bernut A, Dupont C, Ogryzko NV, Neyret A, Herrmann JL, Floto RA, Renshaw SA, Kremer L. | 04/25/2020 |
| CFTR is involved in the regulation of Wnt-dependent hematopoiesis through its interaction with and regulation of the degradation process of a key adaptor protein of Wnt signaling, Dvl2. | CFTR mutation enhances Dishevelled degradation and results in impairment of Wnt-dependent hematopoiesis.
Sun H, Wang Y, Zhang J, Chen Y, Liu Y, Lin Z, Liu M, Sheng K, Liao H, Tsang KS, Zhang X, Jiang X, Xu W, Mao M, Chan HC., Free PMC Article | 04/11/2020 |
| Described here is the chloride pathway of CFTR in atomic resolution for the first time. The results suggest that several intra- and extracellular entry sites may exist, no large conformational changes of the closed structures are required for opening and lipids may influence the channel path directly not only in an allosteric manner. | Discovering the chloride pathway in the CFTR channel.
Farkas B, Tordai H, Padányi R, Tordai A, Gera J, Paragi G, Hegedűs T., Free PMC Article | 03/7/2020 |
| data not only provide a reasonable explanation for the unexpected closed-state structure of phosphorylated E1372Q-zCFTR with a canonical ATP-bound dimer of the nucleotide binding domains (NBDs), but also implicate significant structural and functional differences between these two evolutionarily distant orthologs. | Functional characterization reveals that zebrafish CFTR prefers to occupy closed channel conformations.
Zhang J, Yu YC, Yeh JT, Hwang TC., Free PMC Article | 05/25/2019 |
| study revealed an important role of cystic fibrosis transmembrane conductance regulator (CFTR) acting as an ion channel in regulating primordial germ cell migration during early embryogenesis | CFTR is required for the migration of primordial germ cells during zebrafish early embryogenesis.
Liao H, Chen Y, Li Y, Xue S, Liu M, Lin Z, Liu Y, Chan HC, Zhang X, Sun H., Free PMC Article | 12/1/2018 |
| Molecular dynamics of the cryo-EM CFTR structure | Molecular dynamics of the cryo-EM CFTR structure.
Tordai H, Leveles I, Hegedűs T. | 10/14/2017 |
| Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening. | Conformational Changes of CFTR upon Phosphorylation and ATP Binding.
Zhang Z, Liu F, Chen J. | 08/12/2017 |
| Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical. | Atomic Structure of the Cystic Fibrosis Transmembrane Conductance Regulator.
Zhang Z, Chen J. | 05/13/2017 |
| Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis of the human pancreas. | Loss of cftr function leads to pancreatic destruction in larval zebrafish.
Navis A, Bagnat M., Free PMC Article | 05/9/2015 |