| Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites. | Genetic polymorphism in untranslated regions of PRKCZ influences mRNA structure, stability and binding sites.
Mustafa A, Shabbir M, Badshah Y, Khan K, Abid F, Trembley JH, Afsar T, Almajwal A, Razak S., Free PMC Article | 09/17/2024 |
| PKCzeta phosphorylates VASP to mediate chemotaxis in breast cancer cells. | PKCζ phosphorylates VASP to mediate chemotaxis in breast cancer cells.
Wang C, Zhao X, Zhao L, Wang Y, Jia Y, Zhang X, Ma W. | 01/3/2024 |
| PKCzeta activation promotes maturation of cord blood T cells towards a Th1 IFN-gamma propensity. | PKCζ activation promotes maturation of cord blood T cells towards a Th1 IFN-γ propensity.
Perveen K, Quach A, Stark MJ, Prescott S, Barry SC, Hii CS, Ferrante A. | 10/23/2023 |
| PKC-zeta mediated reduction of the extracellular vesicles-associated TGF-beta1 overcomes radiotherapy resistance in breast cancer. | PKC-ζ mediated reduction of the extracellular vesicles-associated TGF-β1 overcomes radiotherapy resistance in breast cancer.
Zhang F, Zheng Z, Wang L, Zeng W, Wei W, Zhang C, Zhao Z, Liang W., Free PMC Article | 04/12/2023 |
| Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma. | Methylation-mediated silencing of protein kinase C zeta induces apoptosis avoidance through ATM/CHK2 inactivation in dedifferentiated chondrosarcoma.
Shimada E, Matsumoto Y, Nakagawa M, Susuki Y, Endo M, Setsu N, Fujiwara T, Iida K, Nabeshima A, Yahiro K, Kimura A, Hirose T, Kanahori M, Oyama R, Oda Y, Nakashima Y., Free PMC Article | 05/7/2022 |
| Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c. | Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c.
Shaha S, Patel K, Saadat S, Panahi S, de Almeida MM, Voronova A, Riddell M. | 03/12/2022 |
| Cord Blood T Cells Expressing High and Low PKCzeta Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively. | Cord Blood T Cells Expressing High and Low PKCζ Levels Develop into Cells with a Propensity to Display Th1 and Th9 Cytokine Profiles, Respectively.
Perveen K, Quach A, McPhee A, Prescott SL, Barry SC, Hii CS, Ferrante A., Free PMC Article | 06/19/2021 |
| A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity. | A polybasic domain in aPKC mediates Par6-dependent control of membrane targeting and kinase activity.
Dong W, Lu J, Zhang X, Wu Y, Lettieri K, Hammond GR, Hong Y., Free PMC Article | 03/20/2021 |
| Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCzeta pathway in p16(INK4a)-silenced cells. | Mitochondrial nucleoid remodeling and biogenesis are regulated by the p53-p21(WAF1)-PKCζ pathway in p16(INK4a)-silenced cells.
Lee YY, Choi YS, Kim DW, Cheong JY, Song KY, Ryu MS, Lim IK., Free PMC Article | 02/27/2021 |
| Bone metastatic breast cancer cells display downregulation of PKC-zeta with enhanced glutamine metabolism. | Bone metastatic breast cancer cells display downregulation of PKC-ζ with enhanced glutamine metabolism.
Tandon M, Othman AH, Winogradzki M, Pratap J. | 02/20/2021 |
| Intracellular sphingosine 1-phosphate (S1P) directly bound to the purified kinase domain of atypical protein kinase C (aPKC) isozymes (aPKC) and relieved autoinhibitory constraints, thereby activating the kinase. | Activation of atypical protein kinase C by sphingosine 1-phosphate revealed by an aPKC-specific activity reporter.
Kajimoto T, Caliman AD, Tobias IS, Okada T, Pilo CA, Van AN, Andrew McCammon J, Nakamura SI, Newton AC., Free PMC Article | 03/21/2020 |
| Indomethacin impairs mitochondrial dynamics by activating the PKCzeta-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells. | Indomethacin impairs mitochondrial dynamics by activating the PKCζ-p38-DRP1 pathway and inducing apoptosis in gastric cancer and normal mucosal cells.
Mazumder S, De R, Debsharma S, Bindu S, Maity P, Sarkar S, Saha SJ, Siddiqui AA, Banerjee C, Nag S, Saha D, Pramanik S, Mitra K, Bandyopadhyay U., Free PMC Article | 12/14/2019 |
| Defective PKCz control of interphase centrosome anchoring may underlie distinct categories of mitotic slippage that shape the development of low- or high-grade colorectal cancer phenotypes. | Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.
Deevi RK, Javadi A, McClements J, Vohhodina J, Savage K, Loughrey MB, Evergren E, Campbell FC., Free PMC Article | 07/20/2019 |
| Atypical protein kinase C zeta and protein kinase C lambda/iota expression are reduced in human serrated tumors. | Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance.
Nakanishi Y, Duran A, L'Hermitte A, Shelton PM, Nakanishi N, Reina-Campos M, Huang J, Soldevila F, Baaten BJG, Tauriello DVF, Castilla EA, Bhangoo MS, Bao F, Sigal D, Diaz-Meco MT, Moscat J., Free PMC Article | 06/1/2019 |
| CCAT1 knockdown promoted M2 macrophage polarization by up-regulation of miR-148a and down-regulation of PKCzeta expression in prostate cancer cells. | Long non-coding RNA CCAT1/miR-148a/PKCζ prevents cell migration of prostate cancer by altering macrophage polarization.
Liu J, Ding D, Jiang Z, Du T, Liu J, Kong Z. | 04/13/2019 |
| Our findings demonstrate the mechanism of PKCzeta as a new phosphorylase of SIRT6 on maintaining tumor fatty acid beta-oxidation and define the new role of PKCzeta in lipid homeostasis. | PKCζ Phosphorylates SIRT6 to Mediate Fatty Acid β-Oxidation in Colon Cancer Cells.
Gao T, Li M, Mu G, Hou T, Zhu WG, Yang Y., Free PMC Article | 02/16/2019 |
| Protein kinase C acts as a tumor suppressor.Cancer-associated mutations in protein kinase C are generally loss-of-function mutations.[review] | Protein kinase C as a tumor suppressor.
Newton AC., Free PMC Article | 11/3/2018 |
| We also carried out PKC-iota and PKC-zeta directed siRNA treatments to prove the above observations. Immunoprecipitation data suggested an association between PKC-iota and vimentin and PKC-iota siRNA treatments confirmed that PKC-iota activates vimentin by phosphorylation. These results further suggested that PKC-iota is involved in signaling pathways which upregulate EMT and which can be effectively suppressed using A... | Two novel atypical PKC inhibitors; ACPD and DNDA effectively mitigate cell proliferation and epithelial to mesenchymal transition of metastatic melanoma while inducing apoptosis.
Ratnayake WS, Apostolatos AH, Ostrov DA, Acevedo-Duncan M., Free PMC Article | 07/28/2018 |
| PKCzeta promoted lung adenocarcinoma invasion and metastasis, and its expression was associated with MMP2 and MMP9 expression. | PKCζ, MMP‑2 and MMP‑9 expression in lung adenocarcinoma and association with a metastatic phenotype.
Cai X, Zhu H, Li Y. | 06/30/2018 |
| PKC-zeta may be responsible for the abnormal growth, proliferation, and migration of metastatic LOVO colon cancer cells via PKC-zeta/Rac1/Pak1/beta-Catenin pathway. | Protein Kinase C-ζ stimulates colorectal cancer cell carcinogenesis via PKC-ζ/Rac1/Pak1/β-Catenin signaling cascade.
Islam SMA, Patel R, Acevedo-Duncan M. | 06/2/2018 |
| reduced expression of PKCzeta/Pard3/Pard6 contributes to non-small-cell lung cancer epithelial-mesenchymal transition, invasion, and chemoresistance. | Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.
Zhou Q, Dai J, Chen T, Dada LA, Zhang X, Zhang W, DeCamp MM, Winn RA, Sznajder JI, Zhou G., Free PMC Article | 05/19/2018 |
| Intestinal I/R induced the membrane translocation and phosphorylation of PKCzeta. Pretreatment with the PKCzeta activator phosphatidylcholine remarkably attenuated gut injury by suppressing apoptosis. H/R induced PKCzeta to combine with TRAF2, which was phosphorylated by PKCzeta at Ser(55), but not at Ser(11), under intestinal I/R or H/R conditions | PKCζ phosphorylates TRAF2 to protect against intestinal ischemia-reperfusion-induced injury.
Zhou W, Yao J, Wang G, Chen Z, Li Z, Feng D, Li Y, Qasim W, Tan W, Ning S, Tian X., Free PMC Article | 04/7/2018 |
| these results conclude that miR-25 targets PKCzeta and protects osteoblastic cells from Dex via activating AMPK signaling. | microRNA-25 targets PKCζ and protects osteoblastic cells from dexamethasone via activating AMPK signaling.
Fan JB, Liu W, Zhu XH, Yi H, Cui SY, Zhao JN, Cui ZM., Free PMC Article | 03/10/2018 |
| PKCzeta was specifically involved in ACOT7 depletion-mediated cell cycle arrest as an upstream molecule of the p53-p21 signaling pathway in MCF7 human breast carcinoma and A549 human lung carcinoma cells. | Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCζ-p53-p21 signaling pathway.
Jung SH, Lee HC, Hwang HJ, Park HA, Moon YA, Kim BC, Lee HM, Kim KP, Kim YN, Lee BL, Lee JC, Ko YG, Park HJ, Lee JS., Free PMC Article | 03/3/2018 |
| we found that Wnt3a treatment rapidly induces hyperphosphorylation and stabilization of Dvl2 and Dvl3. Our findings suggest a model of positive regulation of PKCzeta-mediated Dvl signaling activity, to produce a strong and sustained response to Wnt3a treatment by stabilizing Dvl protein levels. | Dishevelled stability is positively regulated by PKCζ-mediated phosphorylation induced by Wnt agonists.
Velázquez DM, Castañeda-Patlán MC, Robles-Flores M. | 02/24/2018 |