| LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism. | LMO3 is a suppressor of the basal-like/squamous subtype and reduces disease aggressiveness of pancreatic cancer through glycerol 3-phosphate metabolism.
Ohara Y, Craig AJ, Liu H, Yang S, Moreno P, Dorsey TH, Cawley H, Azizian A, Gaedcke J, Ghadimi M, Hanna N, Ambs S, Hussain SP., | 08/1/2024 |
| Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3. | Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3.
Wei M, Yin R, Qu L, Tang J. | 07/3/2023 |
| Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers. | Hyperglycemia affects neuronal differentiation and Nestin, FOXO1, and LMO3 mRNA expression of human Wharton's jelly mesenchymal stem cells of children from diabetic mothers.
Domínguez-Castro M, Domínguez-Galicia A, Pérez-Pérez O, Hernández-Pineda J, Mancilla-Herrera I, Bazán-Tejeda ML, Rodríguez-Cruz L, González-Torres MC, Montoya-Estrada A, Reyes-Muñoz E, Romo-Yáñez J. | 12/10/2022 |
| Transcriptomic analysis and biological evaluation reveals that LMO3 regulates the osteogenic differentiation of human adipose derived stem cells via PI3K/Akt signaling pathway. | Transcriptomic analysis and biological evaluation reveals that LMO3 regulates the osteogenic differentiation of human adipose derived stem cells via PI3K/Akt signaling pathway.
Kang Y, Pei W. | 05/28/2022 |
| LMO3 reprograms visceral adipocyte metabolism during obesity. | LMO3 reprograms visceral adipocyte metabolism during obesity.
Wagner G, Fenzl A, Lindroos-Christensen J, Einwallner E, Husa J, Witzeneder N, Rauscher S, Gröger M, Derdak S, Mohr T, Sutterlüty H, Klinglmüller F, Wolkerstorfer S, Fondi M, Hoermann G, Cao L, Wagner O, Kiefer FW, Esterbauer H, Bilban M., Free PMC Article | 02/5/2022 |
| MicroRNA-381 inhibits lung adenocarcinoma cell biological progression by directly targeting LMO3 through regulation of the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition. | MicroRNA-381 inhibits lung adenocarcinoma cell biological progression by directly targeting LMO3 through regulation of the PI3K/Akt signaling pathway and epithelial-to-mesenchymal transition.
Xuan YW, Liao M, Zhai WL, Peng LJ, Tang Y. | 12/19/2020 |
| our results suggest that LMO3-BORCS5 fusion oncogene plays an essential role in tumorigenesis | Newly identified LMO3-BORCS5 fusion oncogene in Ewing sarcoma at relapse is a driver of tumor progression.
Dupain C, Gracia C, Harttrampf AC, Rivière J, Geoerger B, Massaad-Massade L. | 02/29/2020 |
| These results suggest that LMO3 promotes hepatocellular carcinoma (HCC) cell invasion and anoikis inhibition by interacting with LATS1 and suppressing Hippo signaling. LMO3 may serve as a potential therapeutic target for HCC in future | LMO3 promotes hepatocellular carcinoma invasion, metastasis and anoikis inhibition by directly interacting with LATS1 and suppressing Hippo signaling.
Cheng Y, Hou T, Ping J, Chen T, Yin B., Free PMC Article | 11/10/2018 |
| These results suggested that LMO3 promotes Gastric Cancer cell invasion and proliferation mainly through Akt/mTOR and Akt/GSK3beta signaling. | LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling.
Qiu YS, Jiang NN, Zhou Y, Yu KY, Gong HY, Liao GJ., Free PMC Article | 09/1/2018 |
| SH3BP5, LMO3, and SNAP25 were expressed in diffuse large B-cell lymphoma cells and associated with clinical features. | Expressions of SH3BP5, LMO3, and SNAP25 in diffuse large B-cell lymphoma cells and their association with clinical features.
Kobayashi K, Yamaguchi M, Miyazaki K, Imai H, Yokoe K, Ono R, Nosaka T, Katayama N., Free PMC Article | 11/11/2017 |
| LMO3 attenuates GATA4-dependent, BMP2-mediated inflammatory endothelial activation. | GATA4 and LMO3 balance angiocrine signaling and autocrine inflammatory activation by BMP2 in liver sinusoidal endothelial cells.
Olsavszky V, Ulbrich F, Singh S, Diett M, Sticht C, Schmid CD, Zierow J, Wohlfeil SA, Schledzewski K, Dooley S, Gaitantzi H, Breitkopf-Heinlein K, Géraud C, Goerdt S, Koch PS. | 09/23/2017 |
| MiR-101 decreased the expression of LMO3 by reversing the methylation status of the LMO3 promoter and by inhibiting the presence of the methylation-related histones H3K4me2 and H3K27me3 and increasing the presence of H3K9me3 and H4K20me3 on the promoter. | MiR-101 reverses the hypomethylation of the LMO3 promoter in glioma cells.
Liu X, Lei Q, Yu Z, Xu G, Tang H, Wang W, Wang Z, Li G, Wu M., Free PMC Article | 05/21/2016 |
| LMO3 as a regulator of human adipogenesis and could contribute a mechanism resulting in visceral-fat accumulation in obesity due to excess glucocorticoids. | Human but not mouse adipogenesis is critically dependent on LMO3.
Lindroos J, Husa J, Mitterer G, Haschemi A, Rauscher S, Haas R, Gröger M, Loewe R, Kohrgruber N, Schrögendorfer KF, Prager G, Beck H, Pospisilik JA, Zeyda M, Stulnig TM, Patsch W, Wagner O, Esterbauer H, Bilban M., Free PMC Article | 03/22/2014 |
| suggest that LMO3 is a transcriptional signal transducer in NKX2-1-amplified lung adenocarcinomas | Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
Watanabe H, Francis JM, Woo MS, Etemad B, Lin W, Fries DF, Peng S, Snyder EL, Tata PR, Izzo F, Schinzel AC, Cho J, Hammerman PS, Verhaak RG, Hahn WC, Rajagopal J, Jacks T, Meyerson M., Free PMC Article | 03/9/2013 |
| We confirmed that the expression of LMO3 in squamous cell carcinoma is regulated by DNA methylation of its specific promoter region. | Genome-wide analysis of DNA methylation and the gene expression change in lung cancer.
Kwon YJ, Lee SJ, Koh JS, Kim SH, Lee HW, Kang MC, Bae JB, Kim YJ, Park JH. | 05/5/2012 |
| The present results suggest that a transcriptional complex of LMO3 and HEN2 may contribute to the genesis and malignant phenotype of neuroblastoma by inhibiting HES1 which suppresses the transactivation of Mash1. | Oncogenic LMO3 collaborates with HEN2 to enhance neuroblastoma cell growth through transactivation of Mash1.
Isogai E, Ohira M, Ozaki T, Oba S, Nakamura Y, Nakagawara A., Free PMC Article | 10/29/2011 |
| LMO3 acts as a co-repressor of p53, suppressing p53-dependent transcriptional regulation without inhibition of its DNA-binding activity. | LMO3 interacts with p53 and inhibits its transcriptional activity.
Larsen S, Yokochi T, Isogai E, Nakamura Y, Ozaki T, Nakagawara A. | 03/29/2010 |
| The deregulated expression of neuronal-specific LMO3 and HEN2 contributes to the genesis and progression of human neuroblastoma in a lineage-specific manner. | LMO3 interacts with neuronal transcription factor, HEN2, and acts as an oncogene in neuroblastoma.
Aoyama M, Ozaki T, Inuzuka H, Tomotsune D, Hirato J, Okamoto Y, Tokita H, Ohira M, Nakagawara A. | 01/21/2010 |