| GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis. | GSDMB involvement in the pathogenesis of abdominal aortic aneurysm through regulation of macrophage non-canonical pyroptosis.
Xie X, Shen X, Liu Y, Zuo Y, Wang S, Zhou Y, Li X, Wang K, Li B, Wang Z. | 09/30/2024 |
| Structural and functional insights into GSDMB isoforms complex roles in pathogenesis. | Structural and functional insights into GSDMB isoforms complex roles in pathogenesis.
Colomo S, Ros-Pardo D, Oltra SS, Gomez-Puertas P, Sarrio D, Moreno-Bueno G., | 12/21/2023 |
| Association between polymorphisms of the GSDMB gene and allergic rhinitis risk in the Chinese population: a case-control study. | Association between polymorphisms of the GSDMB gene and allergic rhinitis risk in the Chinese population: a case-control study.
Shamsi BH, Chen H, Yang X, Liu M, Liu Y. | 07/24/2023 |
| Structural basis for GSDMB pore formation and its targeting by IpaH7.8. | Structural basis for GSDMB pore formation and its targeting by IpaH7.8.
Wang C, Shivcharan S, Tian T, Wright S, Ma D, Chang J, Li K, Song K, Xu C, Rathinam VA, Ruan J., Free PMC Article | 05/13/2023 |
| Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8. | Insights into the GSDMB-mediated cellular lysis and its targeting by IpaH7.8.
Yin H, Zheng J, He Q, Zhang X, Li X, Ma Y, Liang X, Gao J, Kocsis BL, Li Z, Liu X, Alto NM, Li L, Zhang H., Free PMC Article | 01/28/2023 |
| The study of GSDMB in pathogenesis of psoriasis vulgaris. | The study of GSDMB in pathogenesis of psoriasis vulgaris.
Ji X, Chen H, Xie L, Chen S, Huang S, Tan Q, Yang H, Yang T, Ye X, Zeng Z, Wan C, Li L., Free PMC Article | 01/21/2023 |
| GSDM gene polymorphisms regulate the IgE level in asthmatic patients. | GSDM gene polymorphisms regulate the IgE level in asthmatic patients.
Imraish A, Abu-Thiab T, Alhindi T, Zihlif M., Free PMC Article | 10/15/2022 |
| Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB. | Genome-wide study of early and severe childhood asthma identifies interaction between CDHR3 and GSDMB.
Eliasen AU, Pedersen CET, Rasmussen MA, Wang N, Soverini M, Fritz A, Stokholm J, Chawes BL, Morin A, Bork-Jensen J, Grarup N, Pedersen O, Hansen T, Linneberg A, Mortensen PB, Hougaard DM, Bybjerg-Grauholm J, Bækvad-Hansen M, Mors O, Nordentoft M, Børglum AD, Werge T, Agerbo E, Söderhall C, Altman MC, Thysen AH, McKennan CG, Brix S, Gern JE, Ober C, Ahluwalia TS, Bisgaard H, Pedersen AG, Bønnelykke K. | 09/24/2022 |
| Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions. | Pathogenic ubiquitination of GSDMB inhibits NK cell bactericidal functions.
Hansen JM, de Jong MF, Wu Q, Zhang LS, Heisler DB, Alto LT, Alto NM., Free PMC Article | 07/16/2022 |
| Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis. | Upregulated GSDMB in Clear Cell Renal Cell Carcinoma Is Associated with Immune Infiltrates and Poor Prognosis.
Cui Y, Zhou Z, Chai Y, Zhang Y., Free PMC Article | 03/19/2022 |
| USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway. | USP24-GSDMB complex promotes bladder cancer proliferation via activation of the STAT3 pathway.
He H, Yi L, Zhang B, Yan B, Xiao M, Ren J, Zi D, Zhu L, Zhong Z, Zhao X, Jin X, Xiong W., Free PMC Article | 03/19/2022 |
| GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis. | GSDMB is increased in IBD and regulates epithelial restitution/repair independent of pyroptosis.
Rana N, Privitera G, Kondolf HC, Bulek K, Lechuga S, De Salvo C, Corridoni D, Antanaviciute A, Maywald RL, Hurtado AM, Zhao J, Huang EH, Li X, Chan ER, Simmons A, Bamias G, Abbott DW, Heaney JD, Ivanov AI, Pizarro TT., Free PMC Article | 02/26/2022 |
| ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma. | ORMDL3/GSDMB genotype is associated with distinct phenotypes of adult asthma.
Kitazawa H, Masuko H, Kanazawa J, Shigemasa R, Hyodo K, Yamada H, Yatagai Y, Kaneko Y, Iijima H, Naito T, Saito T, Noguchi E, Konno S, Hirota T, Tamari M, Sakamoto T, Hizawa N. | 02/26/2022 |
| Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases. | Association of Gasdermin B Gene GSDMB Polymorphisms with Risk of Allergic Diseases.
Karunas AS, Fedorova YY, Gimalova GF, Etkina EI, Khusnutdinova EK. | 01/22/2022 |
| The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort. | The GSDMB rs7216389 SNP is associated with chronic rhinosinusitis in a multi-institutional cohort.
Zack DE, Stern DA, Willis AL, Kim AS, Mansfield CJ, Reed DR, Brooks SG, Adappa ND, Palmer JN, Cohen NA, Chiu AG, Song BH, Le CH, Chang EH., Free PMC Article | 01/8/2022 |
| Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians. | Association between Gasdermin A, Gasdermin B Polymorphisms and Allergic Rhinitis Amongst Jordanians.
Zihlif M, Mahafza T, Froukh T, Al-Akhras FM, Alsalman R, Zuriekat M, Naffa R. | 11/13/2021 |
| Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study. | Household mold exposure interacts with inflammation-related genetic variants on childhood asthma: a case-control study.
Zhang Y, Hua L, Liu QH, Chu SY, Gan YX, Wu M, Bao YX, Chen Q, Zhang J., Free PMC Article | 10/23/2021 |
| Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways. | Genetic analyses identify GSDMB associated with asthma severity, exacerbations, and antiviral pathways.
Li X, Christenson SA, Modena B, Li H, Busse WW, Castro M, Denlinger LC, Erzurum SC, Fahy JV, Gaston B, Hastie AT, Israel E, Jarjour NN, Levy BD, Moore WC, Woodruff PG, Kaminski N, Wenzel SE, Bleecker ER, Meyers DA, NHLBI Severe Asthma Research Program (SARP)., Free PMC Article | 09/25/2021 |
| GSDMB promotes caspase-4 activity, which is required for the cleavage of GSDMD in non-canonical pyroptosis, by directly binding to the CARD domain of caspase-4. | GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity.
Chen Q, Shi P, Wang Y, Zou D, Wu X, Wang D, Hu Q, Zou Y, Huang Z, Ren J, Lin Z, Gao X., Free PMC Article | 07/18/2020 |
| this study demonstrated that GZMA from cytotoxic lymphocytes cleaves and activates GSDMB to induce target cell pyroptosis. | Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells.
Zhou Z, He H, Wang K, Shi X, Wang Y, Su Y, Wang Y, Li D, Liu W, Zhang Y, Shen L, Han W, Shen L, Ding J, Shao F. | 06/13/2020 |
| Our study identified a functional asthma variant in the GSDMB gene of the 17q21 locus and implicates GSDMB-mediated epithelial cell pyroptosis in pathogenesis. | A functional splice variant associated with decreased asthma risk abolishes the ability of gasdermin B to induce epithelial cell pyroptosis.
Panganiban RA, Sun M, Dahlin A, Park HR, Kan M, Himes BE, Mitchel JA, Iribarren C, Jorgenson E, Randell SH, Israel E, Tantisira K, Shore S, Park JA, Weiss ST, Wu AC, Lu Q., Free PMC Article | 09/21/2019 |
| we show that local CpG methylation mediates a proportion, but not all, of the functional effects of cis-acting asthma-susceptibility regulatory variants on GSDMB and ORMDL3 gene expression | Role of local CpG DNA methylation in mediating the 17q21 asthma susceptibility gasdermin B (GSDMB)/ORMDL sphingolipid biosynthesis regulator 3 (ORMDL3) expression quantitative trait locus.
Kothari PH, Qiu W, Croteau-Chonka DC, Martinez FD, Liu AH, Lemanske RF Jr, Ober C, Krishnan JA, Nicolae DL, Barnes KC, London SJ, Barraza-Villarreal A, White SR, Naureckas ET, Millstein J, Gauderman WJ, Gilliland FD, Carey VJ, Weiss ST, Raby BA, Asthma BioRepository for Integrative Genomic Exploration (Asthma BRIDGE) Consortium., Free PMC Article | 08/3/2019 |
| These results showed that the PBC susceptibility allele of rs12946510 disrupted the enhancer region for ORMDL3 and GSDMB gene expression (Fig. 6). Chromatin interaction between the sequence that contains rs12946510 and the upstream sequence of ORMDL3 and GSDMB also supported this enhancer model | Identification of the functional variant driving ORMDL3 and GSDMB expression in human chromosome 17q12-21 in primary biliary cholangitis.
Hitomi Y, Kojima K, Kawashima M, Kawai Y, Nishida N, Aiba Y, Yasunami M, Nagasaki M, Nakamura M, Tokunaga K., Free PMC Article | 12/22/2018 |
| These studies demonstrate that GSDMB, a gene highly linked to asthma but whose function in asthma is previously unknown, regulates AHR and airway remodeling without airway inflammation through a previously unrecognized pathway in which GSDMB induces 5-LO to induce TGF-beta1 in bronchial epithelium. | GSDMB induces an asthma phenotype characterized by increased airway responsiveness and remodeling without lung inflammation.
Das S, Miller M, Beppu AK, Mueller J, McGeough MD, Vuong C, Karta MR, Rosenthal P, Chouiali F, Doherty TA, Kurten RC, Hamid Q, Hoffman HM, Broide DH., Free PMC Article | 04/28/2018 |
| Full-length GSDMB and its N-terminal domain bind to phosphoinositides or sulfatide, but not cardiolipin. The GSDMB N-terminal domain binds liposomes containing sulfatide, suggesting a role in sulfatide transport. A loop with SNP AAs from controls (Gly299:Pro306) shows high conformational flexibility, but one with AAs (Arg299:Ser306) from people at risk for IBD and asthma is less so and has higher positive surface charge. | Gene polymorphism linked to increased asthma and IBD risk alters gasdermin-B structure, a sulfatide and phosphoinositide binding protein.
Chao KL, Kulakova L, Herzberg O., Free PMC Article | 04/21/2018 |