| KRAS[G12C] mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer. | KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer.
Cai C, Yao S, Zou Y, Lu H, Chen X, Wang Y, Zheng K, Zhu F, Wang Y, Xiong H, Zhu J., Free PMC Article | 06/25/2023 |
| TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway. | TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway.
Wu W, Xu J, Gao D, Xie Z, Chen W, Li W, Yuan Q, Duan L, Zhang Y, Yang X, Chen Y, Dong Z, Liu K, Jiang Y., Free PMC Article | 06/23/2023 |
| TOPK inhibits TNF-alpha-induced granulosa cell apoptosis via regulation of SIRT1/p53. | TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53.
Joo NR, Park SA, Park JH, Oh SM. | 06/12/2023 |
| PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway. | PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway.
Feng T, Jiang R, Yin L, Xu C, Ma J, Yin W, Jin J, Lu T, Liu X, Lyu Y, Yang Y, Ying L, Hu Q, Su D, Ling S. | 04/19/2023 |
| Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis. | Overexpression of PBK/TOPK relates to poor prognosis of patients with breast cancer: a retrospective analysis.
Qiao L, Ba J, Xie J, Zhu R, Wan Y, Zhang M, Jin Z, Guo Z, Yu J, Chen S, Yao Y., Free PMC Article | 10/8/2022 |
| PBK drives PARP inhibitor resistance through the TRIM37/NFkappaB axis in ovarian cancer. | PBK drives PARP inhibitor resistance through the TRIM37/NFκB axis in ovarian cancer.
Ma H, Qi G, Han F, Peng J, Yuan C, Kong B., Free PMC Article | 08/20/2022 |
| TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1. | TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1.
Li J, Zhang ZC, Yuan XS, Tang SS, Wang T, Liu HF, Cao Y., Free PMC Article | 07/2/2022 |
| TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC. | TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC.
Sun H, Zheng J, Xiao J, Yue J, Shi Z, Xuan Z, Chen C, Zhao Y, Tang W, Ye S, Li J, Deng Q, Zhang L, Zhu F, Shao C., Free PMC Article | 06/11/2022 |
| Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma. | Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma.
Deng Y, Wen H, Yang H, Zhu Z, Huang Q, Bi Y, Wang P, Zhou M, Guan J, Zhang W, Li M., Free PMC Article | 05/28/2022 |
| T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma. | T-LAK cell-originated protein kinase (TOPK): an emerging prognostic biomarker and therapeutic target in osteosarcoma.
Thanindratarn P, Wei R, Dean DC, Singh A, Federman N, Nelson SD, Hornicek FJ, Duan Z., Free PMC Article | 04/16/2022 |
| Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway. | Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway.
Cui J, Guo R, Wang Y, Song Y, Song X, Li H, Song X, Li J., Free PMC Article | 03/26/2022 |
| The role of T-LAK cell-originated protein kinase in targeted cancer therapy. | The role of T-LAK cell-originated protein kinase in targeted cancer therapy.
Zhang L, Wang F, Yi H, Ermakova SP, Malyarenko OS, Mo J, Huang Y, Duan Q, Xiao J, Zhu F. | 03/26/2022 |
| Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress. | Targeting TOPK sensitises tumour cells to radiation-induced damage by enhancing replication stress.
Herbert KJ, Puliyadi R, Prevo R, Rodriguez-Berriguete G, Ryan A, Ramadan K, Higgins GS., Free PMC Article | 01/29/2022 |
| Prolactin-regulated Pbk is involved in pregnancy-induced beta-cell proliferation in mice. | Prolactin-regulated Pbk is involved in pregnancy-induced β-cell proliferation in mice.
Cao Y, Feng Z, He X, Zhang X, Xing B, Wu Y, Hojnacki T, Katona BW, Ma J, Zhan X, Hua X. | 12/25/2021 |
| PBK promotes aggressive phenotypes of cervical cancer through ERK/c-Myc signaling pathway. | PBK promotes aggressive phenotypes of cervical cancer through ERK/c-Myc signaling pathway.
Ma H, Han F, Yan X, Qi G, Li Y, Li R, Yan S, Yuan C, Song K, Kong B. | 09/25/2021 |
| PBK expression predicts favorable survival in colorectal cancer patients. | PBK expression predicts favorable survival in colorectal cancer patients.
Nagano-Matsuo A, Inoue S, Koshino A, Ota A, Nakao K, Komura M, Kato H, Naiki-Ito A, Watanabe K, Nagayasu Y, Hosokawa Y, Takiguchi S, Kasugai K, Kasai K, Inaguma S, Takahashi S. | 09/11/2021 |
| Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells. | Novel Interleukin-6 Inducible Gene PDZ-Binding Kinase Promotes Tumor Growth of Multiple Myeloma Cells.
Ota A, Hanamura I, Karnan S, Inaguma S, Takei N, Lam VQ, Mizuno S, Kanasugi J, Wahiduzzaman M, Rahman ML, Hyodo T, Konishi H, Tsuzuki S, Ikeda H, Takami A, Hosokawa Y., Free PMC Article | 09/4/2021 |
| PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN. | PBK/TOPK promotes chemoresistance to oxaliplatin in hepatocellular carcinoma cells by regulating PTEN.
Cao H, Yang M, Yang Y, Fang J, Cui Y. | 07/17/2021 |
| PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells. | PBK attenuates paclitaxel-induced autophagic cell death by suppressing p53 in H460 non-small-cell lung cancer cells.
Park JH, Park SA, Lee YJ, Park HW, Oh SM., Free PMC Article | 07/10/2021 |
| TOPK inhibition accelerates oxidative stressinduced granulosa cell apoptosis via the p53/SIRT1 axis. | TOPK inhibition accelerates oxidative stress‑induced granulosa cell apoptosis via the p53/SIRT1 axis.
Park JH, Park SA, Lee YJ, Joo NR, Shin J, Oh SM. | 07/3/2021 |
| T-LAK cell-originated protein kinase (TOPK) enhances androgen receptor splice variant (ARv7) and drives androgen-independent growth in prostate cancer. | T-LAK cell-originated protein kinase (TOPK) enhances androgen receptor splice variant (ARv7) and drives androgen-independent growth in prostate cancer.
Alhawas L, Amin KS, Salla B, Banerjee PP. | 06/26/2021 |
| TOPK mediates hypoxia-induced epithelial-mesenchymal transition and the invasion of nonsmall-cell lung cancer cells via the HIF-1alpha/snail axis. | TOPK mediates hypoxia-induced epithelial-mesenchymal transition and the invasion of nonsmall-cell lung cancer cells via the HIF-1α/snail axis.
Park JH, Moon M, Kim JS, Oh SM. | 04/24/2021 |
| PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study. | PBK Expression Is Associated With Prognosis of Patients With Oral Squamous Cell Carcinoma Treated With Radiotherapy: A Retrospective Study.
Yu WN, Lin HF, Lee YI, Shia WC, Sung WW, Yeh CM, Lin YM. | 04/13/2021 |
| Activation of NF-kappaB by TOPK upregulates Snail/Slug expression in TGF-beta1 signaling to induce epithelial-mesenchymal transition and invasion of breast cancer cells. | Activation of NF-κB by TOPK upregulates Snail/Slug expression in TGF-β1 signaling to induce epithelial-mesenchymal transition and invasion of breast cancer cells.
Lee YJ, Park JH, Oh SM. | 02/27/2021 |
| A novel loss-of-function mutation of PBK associated with human kidney stone disease. | A novel loss-of-function mutation of PBK associated with human kidney stone disease.
Nettuwakul C, Sawasdee N, Praditsap O, Rungroj N, Pasena A, Dechtawewat T, Deejai N, Sritippayawan S, Rojsatapong S, Chaowagul W, Yenchitsomanus PT., Free PMC Article | 12/26/2020 |