| The role of protein kinase D (PKD) in obesity: Lessons from the heart and other tissues. | The role of protein kinase D (PKD) in obesity: Lessons from the heart and other tissues.
Renton MC, McGee SL, Howlett KF. | 09/9/2024 |
| Protein kinase D (PKD) on the crossroad of lipid absorption, synthesis and utilization. | Protein kinase D (PKD) on the crossroad of lipid absorption, synthesis and utilization.
Wit M, Belykh A, Sumara G. | 01/17/2024 |
| Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanism. | Protein kinase D activity is a risk biomarker in prostate cancer that drives cell invasion by a Snail/ERK dependent mechanism.
Cilleros-Rodríguez D, Toledo-Lobo MV, Martínez-Martínez D, Baquero P, Angulo JC, Chiloeches A, Iglesias T, Lasa M. | 11/16/2023 |
| Protein kinase D1 overexpression potentiates epidermal growth factor signaling pathway in MCF-7 cells. | Protein kinase D1 overexpression potentiates epidermal growth factor signaling pathway in MCF-7 cells.
Legay C, Doublier S, Babajko S, Ricort JM. | 03/30/2023 |
| IL-33 via PKCmu/PRKD1 Mediated alpha-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage. | IL-33 via PKCμ/PRKD1 Mediated α-Catenin Phosphorylation Regulates Endothelial Cell-Barrier Integrity and Ischemia-Induced Vascular Leakage.
Sharma D, Kaur G, Bisen S, Sharma A, Ibrahim AS, Singh NK., Free PMC Article | 03/14/2023 |
| PKD autoinhibition in trans regulates activation loop autophosphorylation in cis. | PKD autoinhibition in trans regulates activation loop autophosphorylation in cis.
Reinhardt R, Hirzel K, Link G, Eisler SA, Hägele T, Parson MAH, Burke JE, Hausser A, Leonard TA., Free PMC Article | 02/28/2023 |
| Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory. | Phosphorylation-dependent positive feedback on the oxytocin receptor through the kinase PKD1 contributes to long-term social memory.
Wang F, Yin XS, Lu J, Cen C, Wang Y. | 04/9/2022 |
| Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination. | Protein kinase D1 variant associated with human epilepsy and peripheral nerve hypermyelination.
Omer S, Jin SC, Koumangoye R, Robert SM, Duran D, Nelson-Williams C, Huttner A, DiLuna M, Kahle KT, Delpire E. | 01/1/2022 |
| Protein kinase D, ubiquitin and proteasome pathways are involved in adenosine receptor-stimulated NR4A expression in myeloid cells. | Protein kinase D, ubiquitin and proteasome pathways are involved in adenosine receptor-stimulated NR4A expression in myeloid cells.
Giffney HE, Cummins EP, Murphy EP, Brayden DJ, Crean D. | 07/3/2021 |
| Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice. | Protein Kinase D1, Reduced in Human Pancreatic Tumors, Increases Secretion of Small Extracellular Vesicles From Cancer Cells That Promote Metastasis to Lung in Mice.
Armacki M, Polaschek S, Waldenmaier M, Morawe M, Ruhland C, Schmid R, Lechel A, Tharehalli U, Steup C, Bektas Y, Li H, Kraus JM, Kestler HA, Kruger S, Ormanns S, Walther P, Eiseler T, Seufferlein T. | 04/17/2021 |
| HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1. | HDAC4 and 5 repression of TBX5 is relieved by protein kinase D1.
Ghosh TK, Aparicio-Sánchez JJ, Buxton S, Brook JD., Free PMC Article | 11/21/2020 |
| A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets. | A role for PKD1 in insulin secretion downstream of P2Y(1) receptor activation in mouse and human islets.
Khan S, Ferdaoussi M, Bautista A, Bergeron V, Smith N, Poitout V, MacDonald PE., Free PMC Article | 09/5/2020 |
| This study suggests a novel role of protein kinase D1 as a key modulator of the glucose metabolism in pancreatic cancer cells accelerating tumorigenesis and chemo-resistance. The remodelling of PKD1-dysregulated glucose metabolism can be achieved by regulation of mTORC1 for development of novel therapeutic strategies. | Protein kinase D1 regulates metabolic switch in pancreatic cancer via modulation of mTORC1.
Kumari S, Khan S, Sekhri R, Mandil H, Behrman S, Yallapu MM, Chauhan SC, Jaggi M., Free PMC Article | 07/25/2020 |
| Study demonstrated that protein kinase D1 (Prkd1) is a direct transcriptional target of Twist1 and is not expressed in the normal mammary epithelium. In patients with breast cancer, TWIST1 and PRKD1 expression correlated with metastatic recurrence. Data identify Prkd1 as a novel and targetable signaling node downstream of Twist1 that is required for epithelial invasion and dissemination. | Twist1-Induced Epithelial Dissemination Requires Prkd1 Signaling.
Georgess D, Padmanaban V, Sirka OK, Coutinho K, Choi A, Frid G, Neumann NM, Inoue T, Ewald AJ., Free PMC Article | 06/20/2020 |
| PKD knockdown in human umbilical vein endothelial cells increases binding of AP2beta to the VEGFR-2 promoter. | Protein kinase D up-regulates transcription of VEGF receptor-2 in endothelial cells by suppressing nuclear localization of the transcription factor AP2β.
Wang Y, Hoeppner LH, Angom RS, Wang E, Dutta S, Doeppler HR, Wang F, Shen T, Scarisbrick IA, Guha S, Storz P, Bhattacharya R, Mukhopadhyay D., Free PMC Article | 06/6/2020 |
| this study shows that protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus | Protein kinase D mediates inflammatory responses of human placental macrophages to Group B Streptococcus.
Sutton JA, Rogers LM, Dixon BREA, Kirk L, Doster R, Algood HM, Gaddy JA, Flaherty R, Manning SD, Aronoff DM., Free PMC Article | 05/9/2020 |
| Protein kinase D-mediated recruitment of intact PAR2 from the Golgi apparatus to the plasma membrane is required for recovery of proteases. | Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2.
Zhao P, Pattison LA, Jensen DD, Jimenez-Vargas NN, Latorre R, Lieu T, Jaramillo JO, Lopez-Lopez C, Poole DP, Vanner SJ, Schmidt BL, Bunnett NW., Free PMC Article | 03/14/2020 |
| Authors showed that PrKD1 phosphorylates all CDC25 isoforms (known substrates of CHEK kinases), independent from CHEK kinases, suggesting that direct phosphorylation of CDC25 by PrKD1 may be an alternate mechanism of G1 arrest. | Protein kinase D1 induces G1-phase cell-cycle arrest independent of Checkpoint kinases by phosphorylating Cell Division Cycle Phosphatase 25.
Nickkholgh B, Sittadjody S, Ordonez K, Rothberg MB, Balaji KC., Free PMC Article | 01/25/2020 |
| Our findings demonstrate that recurrent and high-grade salivary gland polymorphous adenocarcinomas are underpinned by PRKD1 E710D hotspot mutations or PRKD2 rearrangements | Genomic analysis of recurrences and high-grade forms of polymorphous adenocarcinoma.
Sebastiao APM, Pareja F, Kumar R, Brown DN, Silveira C, da Silva EM, Lee JY, Del A, Katabi N, Chiosea S, Weigelt B, Reis-Filho JS, Seethala RR., Free PMC Article | 01/25/2020 |
| PRKD1-mediated classical protein secretory pathway regulates the H-Ras oncogene-induced senescence-associated secretory phenotype. | The protein kinase D1-mediated classical protein secretory pathway regulates the Ras oncogene-induced senescence response.
Su Y, Wang P, Shen H, Sun Z, Xu C, Li G, Tong T, Chen J. | 10/26/2019 |
| deletion of PKD1 promotes expression of the beta3-adrenergic receptor (ADRB3) in a CCAAT/enhancer binding protein (C/EBP)-alpha- and delta-dependent manner, which leads to the elevated expression of beige markers in adipocytes and subcutaneous adipose tissue. | Protein kinase D1 deletion in adipocytes enhances energy dissipation and protects against adiposity.
Löffler MC, Mayer AE, Trujillo Viera J, Loza Valdes A, El-Merahbi R, Ade CP, Karwen T, Schmitz W, Slotta A, Erk M, Janaki-Raman S, Matesanz N, Torres JL, Marcos M, Sabio G, Eilers M, Schulze A, Sumara G., Free PMC Article | 10/5/2019 |
| PKD also displays in vitro autocatalytic activity towards a Tyr residue in the P + 1 loop of the activation segment. | Protein kinase D displays intrinsic Tyr autophosphorylation activity: insights into mechanism and regulation.
Cobbaut M, Derua R, Parker PJ, Waelkens E, Janssens V, Van Lint J., Free PMC Article | 06/29/2019 |
| The PRKD1 E710D hotspot mutation is highly specific for identifying PAC on FNA among cases of ACC and PA, whereas the sensitivity is only modest | The PRKD1 E710D hotspot mutation is highly specific in separating polymorphous adenocarcinoma of the palate from adenoid cystic carcinoma and pleomorphic adenoma on FNA.
Andreasen S, Melchior LC, Kiss K, Bishop JA, Høgdall E, Grauslund M, Wessel I, Homøe P, Agander TK. | 05/4/2019 |
| findings reveal that DLC1 maintains basal activation of PKD at the Golgi and Golgi secretory activity, in part by down-regulating Rho-ROCK signaling | The tumor suppressor protein DLC1 maintains protein kinase D activity and Golgi secretory function.
Jensch A, Frey Y, Bitschar K, Weber P, Schmid S, Hausser A, Olayioye MA, Radde NE., Free PMC Article | 04/13/2019 |
| PKD1 not only regulates the hypoxic glycolytic metabolism of cancer cells via regulation of the expression of HIF-1alpha and glycolytic enzymes. | Protein kinase D1 regulates hypoxic metabolism through HIF-1α and glycolytic enzymes incancer cells.
Chen J, Cui B, Fan Y, Li X, Li Q, Du Y, Feng Y, Zhang P. | 10/13/2018 |