| Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis. | Dynamic phosphorylation of CENP-N by CDK1 guides accurate chromosome segregation in mitosis.
Liu R, Dou Z, Tian T, Gao X, Chen L, Yuan X, Wang C, Hao J, Gui P, Mullen M, Aikhionbare F, Niu L, Bi G, Zou P, Zhang X, Fu C, Yao X, Zang J, Liu X., Free PMC Article | 01/30/2024 |
| Clinical implications and immune features of CENPN in breast cancer. | Clinical implications and immune features of CENPN in breast cancer.
Gui Z, Tian Y, Yu T, Liu S, Liu C, Zhang L., Free PMC Article | 09/28/2023 |
| Knockdown of CENPN Inhibits Glucose Metabolism and Induces G1 Arrest in Esophageal Cancer Cells by Regulating PI3K/AKT Signaling Pathway. | Knockdown of CENPN Inhibits Glucose Metabolism and Induces G1 Arrest in Esophageal Cancer Cells by Regulating PI3K/AKT Signaling Pathway.
Xu S, Wei X. | 08/2/2023 |
| Centromere protein N promotes lung adenocarcinoma progression by activating PI3K/AKT signaling pathway. | Centromere protein N promotes lung adenocarcinoma progression by activating PI3K/AKT signaling pathway.
Zheng Y, You H, Duan J, Chen B, Wu C, Chen P, Wang M. | 08/27/2022 |
| CENP-N promotes the compaction of centromeric chromatin. | CENP-N promotes the compaction of centromeric chromatin.
Zhou K, Gebala M, Woods D, Sundararajan K, Edwards G, Krzizike D, Wereszczynski J, Straight AF, Luger K., Free PMC Article | 04/23/2022 |
| The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity? | The Elusive Structure of Centro-Chromatin: Molecular Order or Dynamic Heterogenetity?
Nagpal H, Fierz B. | 05/8/2021 |
| CENP-N stabilizes CENP-A nucleosomes alone and additively with CENP-C in vitro. However, removal of CENP-C and CENP-N from cells, or mutating CENP-A so that it no longer interacts with CENP-C or CENP-N, had no effect on centromeric CENP-A stability in vivo. Thus, the stability of CENP-A nucleosomes in chromatin does not arise solely from its interactions with CENP-C or CENP-N. | Constitutive centromere-associated network contacts confer differential stability on CENP-A nucleosomes in vitro and in the cell.
Cao S, Zhou K, Zhang Z, Luger K, Straight AF., Free PMC Article | 02/9/2019 |
| Collectively, these studies clarify how CENP-N and CENP-C decode and stabilize the non-canonical CENP-A nucleosome to enforce epigenetic centromere specification and kinetochore assembly. | Decoding the centromeric nucleosome through CENP-N.
Pentakota S, Zhou K, Smith C, Maffini S, Petrovic A, Morgan GP, Weir JR, Vetter IR, Musacchio A, Luger K., Free PMC Article | 08/25/2018 |
| this study reports cryo-electron microscopy (cryo-EM), biophysical, biochemical, and cell biological studies of the interaction between the CENP-A nucleosome and CENP-N. | Structural mechanisms of centromeric nucleosome recognition by the kinetochore protein CENP-N.
Chittori S, Hong J, Saunders H, Feng H, Ghirlando R, Kelly AE, Bai Y, Subramaniam S., Free PMC Article | 05/5/2018 |
| Study demonstrate that the CENP-L-N complex plays a crucial role at the core of the 16-subunit Constitutive Centromere-Associated Network through interactions with CENP-C and CENP-H-I-KM. | The CENP-L-N Complex Forms a Critical Node in an Integrated Meshwork of Interactions at the Centromere-Kinetochore Interface.
McKinley KL, Sekulic N, Guo LY, Tsinman T, Black BE, Cheeseman IM., Free PMC Article | 04/30/2016 |
| CENP-N is bound to kinetochores during S phase and G2, but is absent from kinetochores during mitosis and G1. | Dynamics of CENP-N kinetochore binding during the cell cycle.
Hellwig D, Emmerth S, Ulbricht T, Döring V, Hoischen C, Martin R, Samora CP, McAinsh AD, Carroll CW, Straight AF, Meraldi P, Diekmann S., Free PMC Article | 04/7/2012 |
| Data suggest that CENP-N interprets the information encoded within CENP-A nucleosomes and recruits other proteins to centromeric chromatin that are required for centromere function and propagation. | Centromere assembly requires the direct recognition of CENP-A nucleosomes by CENP-N.
Carroll CW, Silva MC, Godek KM, Jansen LE, Straight AF., Free PMC Article | 01/21/2010 |