| ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3. | ASCC3 promotes the immunosuppression and progression of non-small cell lung cancer by impairing the type I interferon response via CAND1-mediated ubiquitination inhibition of STAT3.
Ao YQ, Gao J, Jin C, Wang S, Zhang LC, Deng J, Chen ZW, Wang HK, Jiang JH, Ding JY., Free PMC Article | 01/4/2024 |
| Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange. | Structural and mechanistic insights into the CAND1-mediated SCF substrate receptor exchange.
Shaaban M, Clapperton JA, Ding S, Kunzelmann S, Mäeots ME, Maslen SL, Skehel JM, Enchev RI. | 07/12/2023 |
| Systemwide disassembly and assembly of SCF ubiquitin ligase complexes. | Systemwide disassembly and assembly of SCF ubiquitin ligase complexes.
Baek K, Scott DC, Henneberg LT, King MT, Mann M, Schulman BA., Free PMC Article | 05/3/2023 |
| Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation. | Cullin-associated and neddylation-dissociated 1 protein (CAND1) governs cardiac hypertrophy and heart failure partially through regulating calcineurin degradation.
Li X, Zhang Y, Zhao Y, Zhou Y, Han Q, Yang Y, Zhang L, Shi L, Jin X, Zhang R, Gao H, Xue G, Li D, Zhang ZR, Lu Y, Yang B, Pan Z. | 08/13/2022 |
| CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum. | CAND1 regulates lunapark for the proper tubular network of the endoplasmic reticulum.
Kajiho H, Yamamoto Y, Sakisaka T., Free PMC Article | 11/21/2020 |
| miR-33a and CAND1 played an important role in lung cancer proliferation and cell migration | miR-33a inhibits cell proliferation and invasion by targeting CAND1 in lung cancer.
Kang M, Li Y, Zhao Y, He S, Shi J. | 09/1/2018 |
| describe the identification of the structural determinants responsible for the CA IX/CAND1 interaction | Disclosing the Interaction of Carbonic Anhydrase IX with Cullin-Associated NEDD8-Dissociated Protein 1 by Molecular Modeling and Integrated Binding Measurements.
Buonanno M, Langella E, Zambrano N, Succoio M, Sasso E, Alterio V, Di Fiore A, Sandomenico A, Supuran CT, Scaloni A, Monti SM, De Simone G. | 09/23/2017 |
| Data show that the differentiation of LiSa-2 preadipocytes is associated with an increase of cullin-associated and neddylation-dissociated 1 (CAND1), COP9 signalosome (CSN), neddylated cullin 3 (Cul3) and the BTB protein Keap1. | CAND1 exchange factor promotes Keap1 integration into cullin 3-RING ubiquitin ligase during adipogenesis.
Dubiel D, Ordemann J, Pratschke J, Dubiel W, Naumann M. | 05/21/2016 |
| The Epstein-Barr virus protein BPLF1, is targeted to cullin-RING ubiquitin ligases (CRLs) via the interaction of the conserved helix-2 with helix-23 of cullins, at a site involved in electrostatic interaction with CAND1. | Herpes virus deneddylases interrupt the cullin-RING ligase neddylation cycle by inhibiting the binding of CAND1.
Gastaldello S, Callegari S, Coppotelli G, Hildebrand S, Song M, Masucci MG. | 09/28/2013 |
| We demonstrate that the accumulation of p27 is associated with an increase of CAND1 and a decrease of Skp2 during adipogenesis of human LiSa-2 preadipocytes. CAND1 knockdown reduces p27 and blocks adipogenesis. | CAND1-dependent control of cullin 1-RING Ub ligases is essential for adipogenesis.
Dubiel D, Gierisch ME, Huang X, Dubiel W, Naumann M. | 06/22/2013 |
| Study shows that Cand1 can unambiguously stimulate SCF activity in vitro by enabling an F box protein-Skp1 complex to access Cul1 that was previously occupied by a different F box protein-Skp1 complex, and that Cand1 promotes assembly in vivo of new F box proteins with pre-existing Cul1 molecules. | Cand1 promotes assembly of new SCF complexes through dynamic exchange of F box proteins.
Pierce NW, Lee JE, Liu X, Sweredoski MJ, Graham RL, Larimore EA, Rome M, Zheng N, Clurman BE, Hess S, Shan SO, Deshaies RJ., Free PMC Article | 06/1/2013 |
| CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer. | CAND1 promotes PLK4-mediated centriole overduplication and is frequently disrupted in prostate cancer.
Korzeniewski N, Hohenfellner M, Duensing S., Free PMC Article | 02/2/2013 |
| A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration. | Proteomic analysis identifies dysfunction in cellular transport, energy, and protein metabolism in different brain regions of atypical frontotemporal lobar degeneration.
Martins-de-Souza D, Guest PC, Mann DM, Roeber S, Rahmoune H, Bauder C, Kretzschmar H, Volk B, Baborie A, Bahn S. | 04/26/2012 |
| COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding. | COMMD1 (copper metabolism MURR1 domain-containing protein 1) regulates Cullin RING ligases by preventing CAND1 (Cullin-associated Nedd8-dissociated protein 1) binding.
Mao X, Gluck N, Chen B, Starokadomskyy P, Li H, Maine GN, Burstein E., Free PMC Article | 11/26/2011 |
| CAND1 does not function by sequestering cullins in vivo to prevent substrate receptor autoubiquitination and is likely to regulate cullin RING ligase activity via alternative mechanisms | Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo.
Chua YS, Boh BK, Ponyeam W, Hagen T., Free PMC Article | 08/6/2011 |
| miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression. | miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression.
Murata T, Takayama K, Katayama S, Urano T, Horie-Inoue K, Ikeda K, Takahashi S, Kawazu C, Hasegawa A, Ouchi Y, Homma Y, Hayashizaki Y, Inoue S. | 02/26/2011 |
| SCCRO recruits Ubc12 approximately NEDD8 to the CAND1-Cul1-ROC1 complex but that this is not sufficient to dissociate or overcome the inhibitory effects of CAND1 on cullin neddylation | SCCRO (DCUN1D1) is an essential component of the E3 complex for neddylation.
Kim AY, Bommeljé CC, Lee BE, Yonekawa Y, Choi L, Morris LG, Huang G, Kaufman A, Ryan RJ, Hao B, Ramanathan Y, Singh B., Free PMC Article | 01/21/2010 |
| TIP120A functions as a negative regulator of SCF E3 ubiquitin ligases and may modulate other cullin ligases in a similar fashion. | TIP120A associates with cullins and modulates ubiquitin ligase activity.
Min KW, Hwang JW, Lee JS, Park Y, Tamura TA, Yoon JB. | 01/21/2010 |
| CAND1 & COP9 signalosome (CSN), major deneddylase of cullins, bind to unneddylated CUL1 in mutually exclusive way. Suppression of CAND1 expression by siRNA enhanced interaction between CUL1 & CSN, suggesting that CAND1 inhibited binding of CSN to CUL1. | CAND1 enhances deneddylation of CUL1 by COP9 signalosome.
Min KW, Kwon MJ, Park HS, Park Y, Yoon SK, Yoon JB. | 01/21/2010 |
| binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex | CAND1 binds to unneddylated CUL1 and regulates the formation of SCF ubiquitin E3 ligase complex.
Zheng J, Yang X, Harrell JM, Ryzhikov S, Shim EH, Lykke-Andersen K, Wei N, Sun H, Kobayashi R, Zhang H. | 01/21/2010 |
| selectively binds to unneddylated CUL1 and is dissociated by CUL1 neddylation | NEDD8 modification of CUL1 dissociates p120(CAND1), an inhibitor of CUL1-SKP1 binding and SCF ligases.
Liu J, Furukawa M, Matsumoto T, Xiong Y. | 01/21/2010 |