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    DCAF6 DDB1 and CUL4 associated factor 6 [ Homo sapiens (human) ]

    Gene ID: 55827, updated on 2-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration.

    Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration.
    Ji Y, Li J, Liu S, Zhu J, Yao J, Li KR, Yan B.

    02/1/2024
    The CRL4[DCAF6] E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.

    The CRL4(DCAF6) E3 ligase ubiquitinates CtBP1/2 to induce apoptotic signalling and promote intervertebral disc degeneration.
    Tseng C, Han Y, Lv Z, Song Q, Wang K, Shen H, Chen Z.

    03/8/2023
    Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.

    Autoantibody of NRIP, a novel AChR-interacting protein, plays a detrimental role in myasthenia gravis.
    Tsai LK, Chen IH, Chao CC, Hsueh HW, Chen HH, Huang YH, Weng RW, Lai TY, Tsai YC, Tsao YP, Chen SL., Free PMC Article

    12/4/2021
    Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.

    Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.
    Ye G, Pan R, Zhu L, Zhou D.

    12/19/2020
    Data show that circular RNA circ-DCAF6 (DDB1 and CUL4 associated factor 6) exerts oncogenic properties by downregulating miR-1231 and miR-1256.

    Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer.
    Wu L, Liu D, Yang Y.

    02/29/2020
    High IQWD1 expression is associated with breast cancer.

    Identification of androgen-responsive microRNAs and androgen-related genes in breast cancer.
    Nakano K, Miki Y, Hata S, Ebata A, Takagi K, McNamara KM, Sakurai M, Masuda M, Hirakawa H, Ishida T, Suzuki T, Ohuchi N, Sasano H.

    01/11/2014
    NRIP enhances HPV 16 gene expression via interaction with either GR or viral E2.

    NRIP enhances HPV gene expression via interaction with either GR or E2.
    Chang SW, Lu PY, Guo JH, Tsai TC, Tsao YP, Chen SL.

    03/3/2012
    Observational study of gene-disease association. (HuGE Navigator)See all PubMed (2) articles01/11/2009
    A survey results showed that ten cancer cases were revealed to express the NRIP in six malignancies, but not all of these specific tumor types consistently showed positive NRIP expression.

    Nuclear Receptor Interaction Protein (NRIP) expression assay using human tissue microarray and immunohistochemistry technology confirming nuclear localization.
    Han CP, Lee MY, Tzeng SL, Yao CC, Wang PH, Cheng YW, Chen SL, Wu TS, Tyan YS, Kok LF., Free PMC Article

    01/21/2010
    NRIP plays a feed-forward role enhancing androgen receptor (AR)-driven NRIP promoter activity via NRIP forming a complex with AR to protect AR protein from proteasome degradation.

    Nuclear receptor interaction protein, a coactivator of androgen receptors (AR), is regulated by AR and Sp1 to feed forward and activate its own gene expression through AR protein stability.
    Chen PH, Tsao YP, Wang CC, Chen SL., Free PMC Article

    01/21/2010
    NRIP interacts with either androgen or glucocorticoid receptors

    NRIP, a novel nuclear receptor interaction protein, enhances the transcriptional activity of nuclear receptors.
    Tsai TC, Lee YL, Hsiao WC, Tsao YP, Chen SL.

    01/21/2010
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