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    IL26 interleukin 26 [ Homo sapiens (human) ]

    Gene ID: 55801, updated on 17-Sep-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy.

    The evolving landscape of IL-10, IL-22 and IL-26 in pleurisy especially in tuberculous pleurisy.
    Niu Q, Wang M, Liu XS., Free PMC Article

    07/31/2024
    Increased interleukin-26 in the peripheral joints of patients with axial spondyloarthritis and psoriatic arthritis, co-localizing with CD68-positive synoviocytes.

    Increased interleukin-26 in the peripheral joints of patients with axial spondyloarthritis and psoriatic arthritis, co-localizing with CD68-positive synoviocytes.
    Hammitzsch A, Ossadnik A, Bachmann Q, Merwald-Fraenk H, Lorenz G, Witt M, Wiesent F, Mühlhofer H, Simone D, Bowness P, Heemann U, Arbogast M, Moog P, Schmaderer C., Free PMC Article

    06/5/2024
    Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.

    Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen.
    Kovach MA, Käck U, Che KF, Brundin B, Konradsen JR, Lindén A., Free PMC Article

    04/22/2024
    IL-26 modulates T cell function in autoimmune hepatitis.

    IL-26 modulates T cell function in autoimmune hepatitis.
    He W, Qian QW, Liu QY, Li YK, Miao Q, Wang QX, Ma X, You ZR, Tang RQ.

    07/19/2023
    Interleukin-26-DNA complexes promote inflammation and dermal-epidermal separation in a modified human cryosection model of bullous pemphigoid.

    Interleukin-26-DNA complexes promote inflammation and dermal-epidermal separation in a modified human cryosection model of bullous pemphigoid.
    Mizuno Y, Shibata S, Ito Y, Taira H, Sugimoto E, Awaji K, Sato S., Free PMC Article

    11/5/2022
    Complex Involvement of Interleukin-26 in Bacterial Lung Infection.

    Complex Involvement of Interleukin-26 in Bacterial Lung Infection.
    Che KF, Paulsson M, Piersiala K, Sax J, Mboob I, Rahman M, Rekha RS, Säfholm J, Adner M, Bergman P, Cardell LO, Riesbeck K, Lindén A., Free PMC Article

    02/19/2022
    IL-26 gene variants and protein expression in Tunisian asthmatic patients.

    IL-26 gene variants and protein expression in Tunisian asthmatic patients.
    Salhi M, Tizaoui K, Louhaichi S, Lahmar O, Hamzaoui K, Hamzaoui A.

    11/22/2021
    Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.

    Interleukin-26 Has Synergistic Catabolic Effects with Palmitate in Human Articular Chondrocytes via the TLR4-ERK1/2-c-Jun Signaling Pathway.
    Chen YT, Wang CC, Cheng CP, Liu FC, Lee CH, Lee HS, Peng YJ., Free PMC Article

    11/22/2021
    Serum Interleukin-26 Is a New Biomarker for Disease Activity Assessment in Systemic Lupus Erythematosus.

    Serum Interleukin-26 Is a New Biomarker for Disease Activity Assessment in Systemic Lupus Erythematosus.
    Brilland B, Bach-Bunner M, Gomes CN, Larochette V, Foucher E, Plaisance M, Saulnier P, Costedoat-Chalumeau N, Ghillani P, Belizna C, Delneste Y, Augusto JF, Jeannin P., Free PMC Article

    10/23/2021
    A new T helper 17 cytokine in hidradenitis suppurativa: antimicrobial and proinflammatory role of interleukin-26.

    A new T helper 17 cytokine in hidradenitis suppurativa: antimicrobial and proinflammatory role of interleukin-26.
    Scala E, Di Caprio R, Cacciapuoti S, Caiazzo G, Fusco A, Tortorella E, Fabbrocini G, Balato A.

    03/20/2021
    Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-kappaB Pathway.

    Interleukin 26 Skews Macrophage Polarization Towards M1 Phenotype by Activating cJUN and the NF-κB Pathway.
    Lin YH, Wang YH, Peng YJ, Liu FC, Lin GJ, Huang SH, Sytwu HK, Cheng CP., Free PMC Article

    03/13/2021
    Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis.

    Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis.
    Hawerkamp HC, van Geelen L, Korte J, Di Domizio J, Swidergall M, Momin AA, Guzmán-Vega FJ, Arold ST, Ernst J, Gilliet M, Kalscheuer R, Homey B, Meller S., Free PMC Article

    01/16/2021
    IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.

    IL26, a Noncanonical Mediator of DNA Inflammatory Stimulation, Promotes TNBC Engraftment and Progression in Association with Neutrophils.
    Trotter TN, Shuptrine CW, Tsao LC, Marek RD, Acharya C, Wei JP, Yang XY, Lei G, Wang T, Lyerly HK, Hartman ZC., Free PMC Article

    01/9/2021
    Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.

    Increased IL-26 Expression Promotes T Helper Type 17- and T Helper Type 2-Associated Cytokine Production by Keratinocytes in Atopic Dermatitis.
    Kamijo H, Miyagaki T, Hayashi Y, Akatsuka T, Watanabe-Otobe S, Oka T, Shishido-Takahashi N, Suga H, Sugaya M, Sato S.

    11/21/2020
    IL-26 promotes IL-22 secretion and Th22 generation by CD4(+) T cells isolated from tuberculous pleural effusion patients. IL-26 may play an active role in the pathogenesis of tuberculous pleurisy.

    Interleukin-26 upregulates interleukin-22 production by human CD4(+) T cells in tuberculous pleurisy.
    Zhang M, Niu YR, Liu JY, Wei XS, Wang XR, Ye LL, Peng WB, Zhang JC, Tao XN, Zhou Q.

    06/27/2020
    the Th17 cytokine IL-26 contributes to host defense against intracellular bacteria

    IL-26 contributes to host defense against intracellular bacteria.
    Dang AT, Teles RM, Weiss DI, Parvatiyar K, Sarno EN, Ochoa MT, Cheng G, Gilliet M, Bloom BR, Modlin RL., Free PMC Article

    04/25/2020
    IL-26 acted directly on vascular endothelial cells, promoting proliferation and tube formation, possibly through protein kinase B, extracellular signal-regulated kinase, and NF-kappaB pathways

    Biological Effects of IL-26 on T Cell-Mediated Skin Inflammation, Including Psoriasis.
    Itoh T, Hatano R, Komiya E, Otsuka H, Narita Y, Aune TM, Dang NH, Matsuoka S, Naito H, Tominaga M, Takamori K, Morimoto C, Ohnuma K.

    04/4/2020
    IL-26 is an independent prognostic factor indicating unfavorable prognosis in hepatocellular carcinoma patients with liver resection.

    Expression of IL-26 predicts prognosis of patients with hepatocellular carcinoma after surgical resection.
    Xi ZF, Jeong S, Wang CC, Li HJ, Guo H, Cai J, Li JX, Kong XN, Tong Y, Xia Q.

    01/25/2020
    An observational study suggests IL-26 as a novel potential indicator for inflammation in chronic HBV infection and provides some new information about the mechanism underlying the serum IL-26 elevation in chronic hepatitis B patients.

    The serum interleukin-26 level is a potential biomarker for chronical hepatitis B.
    Luo L, Jiang L, Tian Z, Zhang X., Free PMC Article

    01/18/2020
    increased in airways by long-term but not by short-term tobacco smoking

    The neutrophil-mobilizing cytokine interleukin-26 in the airways of long-term tobacco smokers.
    Che KF, Tufvesson E, Tengvall S, Lappi-Blanco E, Kaarteenaho R, Levänen B, Ekberg M, Brauner A, Wheelock ÅM, Bjermer L, Sköld CM, Lindén A., Free PMC Article

    07/6/2019
    non-specific T-cell killing represents an efficient amplification mechanism of the initially Ag-specific allergic reaction. Our findings suggest that IL-26 could play a crucial role in this amplification mechanism being an allergen independent cytokine highly expressed in ACD patients and constitutively ready to act in complex killing system proper of this disease.

    IL-26 in allergic contact dermatitis: Resource in a state of readiness.
    Caiazzo G, Di Caprio R, Lembo S, Raimondo A, Scala E, Patruno C, Balato A.

    05/25/2019
    this paper shows that IL-26 is overexpressed in Behcet's disease and enhances Th17 related -cytokines

    Interleukin-26 is overexpressed in Behçet's disease and enhances Th17 related -cytokines.
    Kaabachi W, Bouali E, Berraïes A, Dhifallh IB, Hamdi B, Hamzaoui K, Hamzaoui A.

    07/14/2018
    The varIL26 genotype is associated with reduced PMN capacity to kill bacteria. A varIL26 genotype is associated with decreased levels of anti-TNF-alpha in CD patients. IL26 may help explain the role of bactDNA as a risk factor of flare in CD patients.

    IL26 modulates cytokine response and anti-TNF consumption in Crohn's disease patients with bacterial DNA.
    Piñero P, Juanola O, Gutiérrez A, Zapater P, Giménez P, Steinert A, Sempere L, González-Navajas JM, Niess JH, Francés R.

    06/9/2018
    IL-26 activates STAT1/3 and leads to the induction of IL-6 and IL-8 expression in non-transformed cells derived from human colon.

    Expression of Interleukin-26 is upregulated in inflammatory bowel disease.
    Fujii M, Nishida A, Imaeda H, Ohno M, Nishino K, Sakai S, Inatomi O, Bamba S, Kawahara M, Shimizu T, Andoh A., Free PMC Article

    05/12/2018
    IL-26 levels are higher in synovial fluid compared to plasma in spondyloarthritis. IL-26 was identified in axial facet joints of spondyloarthritis patients. Myofibroblasts from the spondyloarthritis synovium produce large amounts of IL-26. IL-26 induces bone mineralization in human osteoblasts.

    Synovial cell production of IL-26 induces bone mineralization in spondyloarthritis.
    Heftdal LD, Andersen T, Jæhger D, Woetmann A, Østgård R, Kenngott EE, Syrbe U, Sieper J, Hvid M, Deleuran B, Kragstrup TW.

    03/17/2018
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