| The store-operated Ca[2+] channel Orai1alpha is required for agonist-evoked NF-kappaB activation by a mechanism dependent on PKCbeta2. | The store-operated Ca(2+) channel Orai1α is required for agonist-evoked NF-κB activation by a mechanism dependent on PKCβ2.
Nieto-Felipe J, Sanchez-Collado J, Jardin I, Salido GM, Lopez JJ, Rosado JA., Free PMC Article | 02/27/2023 |
| Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population. | Family-Based Cohort Association Study of PRKCB1, CBLN1 and KCNMB4 Gene Polymorphisms and Autism in Polish Population.
Iwanicki T, Balcerzyk A, Kazek B, Emich-Widera E, Likus W, Iwanicka J, Kapinos-Gorczyca A, Kapinos M, Jarosz A, Grzeszczak W, Górczyńska-Kosiorz S, Niemiec P., Free PMC Article | 10/15/2022 |
| Therapeutic hypothermia augments the restorative effects of PKC-beta and Nox2 inhibition on an in vitro model of human blood-brain barrier. | Therapeutic hypothermia augments the restorative effects of PKC-β and Nox2 inhibition on an in vitro model of human blood-brain barrier.
Kadir RRA, Alwjwaj M, McCarthy Z, Bayraktutan U., Free PMC Article | 04/16/2022 |
| PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant alpha1B-adrenergic receptors. | PKC-isoform specific regulation of receptor desensitization and KCNQ1/KCNE1 K(+) channel activity by mutant α(1B)-adrenergic receptors.
Renkhold L, Kollmann R, Inderwiedenstraße L, Kienitz MC. | 04/9/2022 |
| PKCbetaII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis. | PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis.
Zhang HL, Hu BX, Li ZL, Du T, Shan JL, Ye ZP, Peng XD, Li X, Huang Y, Zhu XY, Chen YH, Feng GK, Yang D, Deng R, Zhu XF. | 02/26/2022 |
| LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy. | LncRNA VEAL2 regulates PRKCB2 to modulate endothelial permeability in diabetic retinopathy.
Sehgal P, Mathew S, Sivadas A, Ray A, Tanwar J, Vishwakarma S, Ranjan G, Shamsudheen KV, Bhoyar RC, Pateria A, Leonard E, Lalwani M, Vats A, Pappuru RR, Tyagi M, Jakati S, Sengupta S, B K B, Chakrabarti S, Kaur I, Motiani RK, Scaria V, Sivasubbu S., Free PMC Article | 12/4/2021 |
| PKC-beta/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia. | PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Ma D, Liu P, Wang P, Zhou Z, Fang Q, Wang J. | 11/13/2021 |
| Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase eta-knockout mouse brain. | Dopamine and the phosphorylated dopamine transporter are increased in the diacylglycerol kinase η-knockout mouse brain.
Asami M, Suzuki Y, Sakane F. | 07/24/2021 |
| Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence. | Promoter Methylation of PRKCB, ADAMTS12, and NAALAD2 Is Specific to Prostate Cancer and Predicts Biochemical Disease Recurrence.
Daniunaite K, Bakavicius A, Zukauskaite K, Rauluseviciute I, Lazutka JR, Ulys A, Jankevicius F, Jarmalaite S., Free PMC Article | 07/17/2021 |
| Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO(2). | Effect of Activated Protein Kinase C Beta Type Mediated Phosphorylation of Signal Transducer and Activator of Transcription 4 on Proliferation and Phenotypic Transformation of Vascular Smooth Muscle Cells After Vascular Injury Induced by Nano-SiO₂.
Huang P, Zhang X, Pan M, Deng J, Chen Z, Zhou X, Liang M, Liang D. | 06/26/2021 |
| Molecular identification of protein kinase C beta in Alzheimer's disease. | Molecular identification of protein kinase C beta in Alzheimer's disease.
Zhou Z, Chen F, Zhong S, Zhou Y, Zhang R, Kang K, Zhang X, Xu Y, Zhao M, Zhao C., Free PMC Article | 05/15/2021 |
| The Inhibition of Protein Kinase C beta Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy. | The Inhibition of Protein Kinase C β Contributes to the Pathogenesis of Preeclampsia by Activating Autophagy.
Zhao H, Gong L, Wu S, Jing T, Xiao X, Cui Y, Xu H, Lu H, Tang Y, Zhang J, Zhou Q, Ma D, Li X., Free PMC Article | 04/17/2021 |
| PKCbetaII specifically regulates KCNQ1/KCNE1 channel membrane localization. | PKCβII specifically regulates KCNQ1/KCNE1 channel membrane localization.
Braun C, Parks XX, Qudsi H, Lopes CM. | 01/23/2021 |
| A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CbetaII. | A JUN N-terminal kinase inhibitor induces ectodomain shedding of the cancer-associated membrane protease Prss14/epithin via protein kinase CβII.
Yoon J, Cho Y, Kim KY, Yoon MJ, Lee HS, Jeon SD, Cho Y, Kim C, Kim MG., Free PMC Article | 12/26/2020 |
| Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCbeta/Mitochondrial Oxidant Signaling. | Intermittent Hypoxia Augments Pulmonary Vasoconstrictor Reactivity through PKCβ/Mitochondrial Oxidant Signaling.
Snow JB, Norton CE, Sands MA, Weise-Cross L, Yan S, Herbert LM, Sheak JR, Gonzalez Bosc LV, Walker BR, Kanagy NL, Jernigan NL, Resta TC., Free PMC Article | 10/24/2020 |
| Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer. | Genetic variants of the peroxisome proliferator-activated receptor (PPAR) signaling pathway genes and risk of pancreatic cancer.
Liu X, Qian D, Liu H, Abbruzzese JL, Luo S, Walsh KM, Wei Q., Free PMC Article | 10/10/2020 |
| Receptor-specific regulation of atrial GIRK channel activity by different Ca(2+)-dependent PKC isoforms. | Receptor-specific regulation of atrial GIRK channel activity by different Ca(2+)-dependent PKC isoforms.
Niemeyer A, Rinne A, Kienitz MC. | 09/12/2020 |
| Following alpha4beta2 nAChR stimulation, activated PKCbetaII translocated to the plasma membrane to induce clathrin-mediated endocytosis of D3R, resulting in downregulation and signal inhibition. | α4β2 nicotinic acetylcholine receptor downregulates D(3) dopamine receptor expression through protein kinase C activation.
Acharya S, Kim KM. | 06/20/2020 |
| Study revealed that a hyper-methylation in gene promoter, leading to relatively reduced patterns of AVPR1a, OXTR, and PKCB expressions offering new and important information for further understanding the pathological features caused by pre-eclampsia in the fetal vascular system, as well as roles of epigenetic-mediated gene expression in umbilical vascular dysfunction. | Promoter methylation changes and vascular dysfunction in pre-eclamptic umbilical vein.
Gao Q, Fan X, Xu T, Li H, He Y, Yang Y, Chen J, Ding H, Tao J, Xu Z., Free PMC Article | 05/30/2020 |
| PKCbeta as the dominant PKC isoform in mouse peritoneal macrophages is up-regulated by high glucose peritoneal dialysis fluid and exerts anti-inflammatory effects during peritoneal dialysis through regulation of macrophages M1/M2 polarization and control of the dominant mesothelial PKC isoform alpha | Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha.
Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, Shushakova N. | 04/18/2020 |
| The insensitivity of AVP was correlated with the down-regulated AVP receptor 1a (AVPR1A, AVPR1A gene) and protein kinase C isoform beta (PKCbeta, PKCBeta gene), particularly the hyper-methylation-mediated AVPR1A and PKCBeta gene down-regulation. | Hyper-methylation of AVPR1A and PKCΒ gene associated with insensitivity to arginine vasopressin in human pre-eclamptic placental vasculature.
Gao Q, Li H, Ding H, Fan X, Xu T, Tang J, Liu Y, Chen X, Zhou X, Tao J, Xu Z., Free PMC Article | 12/14/2019 |
| Cancer-associated hotspot mutations in the pseudosubstrate of PKCbeta that impair autoinhibition result in dephosphorylated and unstable enzymes. Protein-level analysis reveals that PKCalpha is fully phosphorylated at the PHLPP site in over 5,000 patient tumors, with higher PKC levels correlating (1) inversely with PHLPP1 levels and (2) positively with improved survival in pancreatic adenocarcinoma | Protein Kinase C Quality Control by Phosphatase PHLPP1 Unveils Loss-of-Function Mechanism in Cancer.
Baffi TR, Van AN, Zhao W, Mills GB, Newton AC., Free PMC Article | 10/19/2019 |
| expression of PRKCB mRNA might be correlated with the pathogenesis of systemic lupus erythematosus | Increased expression of PRKCB mRNA in peripheral blood mononuclear cells from patients with systemic lupus erythematosus.
Zhu Z, Yang L, Zhang Y, Liu L, Huang Y, Wen L, Yang C, Chen L, Wang W, Zuo X, Zhou F, Wang H, Tang H, Zhang X, Yang S, Sheng Y, Cui Y. | 07/27/2019 |
| For unraveling mechanisms of RACK1:PKCbetaII-mediated translation stimulation, we used sequentially truncated eIF4G1 in coimmunoprecipitation analyses to delineate a set of autoinhibitory elements in the N-terminal unstructured region (surrounding the eIF4E-binding motif) and the interdomain linker (within the eIF3-binding site) of eIF4G1. | Ribosomal RACK1:Protein Kinase C βII Modulates Intramolecular Interactions between Unstructured Regions of Eukaryotic Initiation Factor 4G (eIF4G) That Control eIF4E and eIF3 Binding.
Dobrikov MI, Dobrikova EY, Gromeier M., Free PMC Article | 06/29/2019 |
| We found that RACK1:PKCbetaII phosphorylates eukaryotic initiation factor 4G1 (eIF4G1) at S1093 and eIF3a at S1364. Our findings reveal a physiological role for ribosomal RACK1 in providing the molecular scaffold for PKCbetaII and its role in coordinating the translational response to PKC-Raf-ERK1/2 activation. | Ribosomal RACK1:Protein Kinase C βII Phosphorylates Eukaryotic Initiation Factor 4G1 at S1093 To Modulate Cap-Dependent and -Independent Translation Initiation.
Dobrikov MI, Dobrikova EY, Gromeier M., Free PMC Article | 06/29/2019 |