| Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2). | Exploring the structural and dynamic differences between human carnosinase I (CN1) and II (CN2).
Tancharoen C, Tovivek B, Niramitranon J, Kityakarn S, Luksirikul P, Gorinstein S, Pongprayoon P. | 05/4/2023 |
| Cytosolic nonspecific dipeptidase 2 promotes the occurrence and development of ovarian cancer through the PI3K/AKT signaling pathway. | CNDP2 Acts as an Activator for Human Ovarian Cancer Growth and Metastasis via the PI3K/AKT Pathway.
Zhang LQ, Yang HQ, Yang SQ, Wang Y, Chen XJ, Lu HS, Zhao LP., Free PMC Article | 02/29/2020 |
| 2 SNPs (rs7244647 in CNDP1 and rs4891558 in CNDP2) were associated with obesity risk. In addition, these associations were observed only in the group with high carbohydrate and low carotene intake but not in the group with low carbohydrate and high carotene intake. | The Combined Effects of Genetic Variation in the CNDP1 and CNDP2 Genes and Dietary Carbohydrate and Carotene Intake on Obesity Risk.
Yamakawa-Kobayashi K, Otagi E, Ohhara Y, Goda T, Kasezawa N, Kayashima Y. | 09/7/2019 |
| The CNDP2 rs6566810 (A/A genotype) is overrepresented in endurance athletes, but only in international-level endurance athletes. Three SNPs (CNDP2 rs3764509, CNDP2-CNDP1 rs2346061, and CNDP1 rs2887) were overrepresented in power athletes compared with nonathletes. | Single Nucleotide Polymorphisms in Carnosinase Genes (CNDP1 and CNDP2) are Associated With Power Athletic Status.
Guilherme JPLF, Lancha AH Jr. | 03/31/2018 |
| These results suggest that the zinc form of CN2 is an active enzyme, but with a different substrate specificity from that of the manganese form. | The zinc form of carnosine dipeptidase 2 (CN2) has dipeptidase activity but its substrate specificity is different from that of the manganese form.
Okumura N, Takao T. | 11/25/2017 |
| To identify substrates of orphan transporter ATP-binding cassette subfamily C member 5 (ABCC5), identified a class of metabolites, N-lactoyl-amino acids, and found that a protease, cytosolic nonspecific dipeptidase 2 (CNDP2), catalyzes their formation. | N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids.
Jansen RS, Addie R, Merkx R, Fish A, Mahakena S, Bleijerveld OB, Altelaar M, IJlst L, Wanders RJ, Borst P, van de Wetering K., Free PMC Article | 08/29/2015 |
| Expression of CN2 in clinical colon tumors and colon cancer cell lines was significantly higher than that in normal colon mucosa cell lines. Knockdown of CNDP2 can inhibit the proliferation of colon cancer in vitro and retarded carcinogenesis in vivo. | Up-regulation of CNDP2 facilitates the proliferation of colon cancer.
Xue C, Zhang Z, Yu H, Yu M, Yuan K, Yang T, Miao M, Shi H., Free PMC Article | 12/20/2014 |
| Results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway. | Underexpressed CNDP2 participates in gastric cancer growth inhibition through activating the MAPK signaling pathway.
Zhang Z, Miao L, Xin X, Zhang J, Yang S, Miao M, Kong X, Jiao B., Free PMC Article | 11/8/2014 |
| a key role of CNDP2 in PD neurodegeneration, by mechanisms that could involve oxidative stress, protein aggregation or inflammation. | Proteomic profiling of the substantia nigra demonstrates CNDP2 overexpression in Parkinson's disease.
Licker V, Côte M, Lobrinus JA, Rodrigo N, Kövari E, Hochstrasser DF, Turck N, Sanchez JC, Burkhard PR. | 12/8/2012 |
| deletion of the CPGL gene is a poor prognostic marker in resected pancreatic cancer, and functional studies suggest the CPGL gene as growth suppressor gene in pancreatic cancer. | Loss of 18q22.3 involving the carboxypeptidase of glutamate-like gene is associated with poor prognosis in resected pancreatic cancer.
Lee JH, Giovannetti E, Hwang JH, Petrini I, Wang Q, Voortman J, Wang Y, Steinberg SM, Funel N, Meltzer PS, Wang Y, Giaccone G., Free PMC Article | 08/4/2012 |
| Common variants in CNDP1 and CNDP2 play a role in susceptibility to kidney disease in patients with type 2 diabetes. | Common variants in CNDP1 and CNDP2, and risk of nephropathy in type 2 diabetes.
Ahluwalia TS, Lindholm E, Groop LC. | 03/10/2012 |
| the crystal structure of the flop-selective allosteric modulator, PEPA, bound to the binding domains of the GluA2 and GluA3 flop isoforms of AMPA receptors | Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA.
Ahmed AH, Ptak CP, Oswald RE., Free PMC Article | 05/31/2010 |
| Our large, comprehensive study did not find an association between the D18S880 microsatellite or any other polymorphisms in the CNDP2-CNDP1 genomic region and susceptibility for diabetic nephropathy in type 1 diabetes | Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS, Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS., Free PMC Articles: PMC2518509, PMC2518509 | 01/21/2010 |
| Observational study of gene-disease association. (HuGE Navigator) | See all PubMed (2) articlesThe influence of carnosinase gene polymorphisms on diabetic nephropathy risk in African-Americans.
McDonough CW, Hicks PJ, Lu L, Langefeld CD, Freedman BI, Bowden DW. Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies.
Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS, Wanic K, Placha G, Dunn J, Smiles A, Warram JH, Krolewski AS. | 09/10/2008 |