| CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via NRF2- ROS axis. | CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via NRF2- ROS axis.
He F, Ye B, Wu X, Pan J, Wang J, Wang X., Free PMC Article | 04/10/2023 |
| Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis. | Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis.
Lu Q, Li Y, Lou J, Li P, Gu Y, Wang X. | 04/30/2022 |
| CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer. | CHFR-Promoter-Methylation Status Is Predictive of Response to Irinotecan-based Systemic Chemotherapy in Advanced Colorectal Cancer.
Hagiwara T, Sugimoto K, Momose H, Irie T, Honjo K, Okazawa YU, Kawai M, Kawano S, Munakata S, Takahashi M, Kojima Y, Serizawa N, Nagahara A, Hoffman RM, Brock MV, Sakamoto K. | 02/12/2022 |
| CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1. | CHFR regulates chemoresistance in triple-negative breast cancer through destabilizing ZEB1.
Luo H, Zhou Z, Huang S, Ma M, Zhao M, Tang L, Quan Y, Zeng Y, Su L, Kim J, Zhang P., Free PMC Article | 01/29/2022 |
| CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells. | CHFR-mediated degradation of RNF126 confers sensitivity to PARP inhibitors in triple-negative breast cancer cells.
Wu W, Zhao J, Xiao J, Wu W, Xie L, Xie X, Yang C, Yin D, Hu K. | 11/22/2021 |
| CHFRmediated epithelialtomesenchymal transition promotes metastasis in human breast cancer cells. | CHFR‑mediated epithelial‑to‑mesenchymal transition promotes metastasis in human breast cancer cells.
Jiang G, Fang H, Shang X, Chen X, Cao F. | 10/23/2021 |
| Kaposi's sarcoma-associated herpesvirus processivity factor (PF-8) recruits cellular E3 ubiquitin ligase CHFR to promote PARP1 degradation and lytic replication. | Kaposi's sarcoma-associated herpesvirus processivity factor (PF-8) recruits cellular E3 ubiquitin ligase CHFR to promote PARP1 degradation and lytic replication.
Chung WC, Lee S, Kim Y, Seo JB, Song MJ., Free PMC Article | 05/15/2021 |
| Circ_CHFR expedites cell growth, migration and inflammation in ox-LDL-treated human vascular smooth muscle cells via the miR-214-3p/Wnt3/beta-catenin pathway. | Circ_CHFR expedites cell growth, migration and inflammation in ox-LDL-treated human vascular smooth muscle cells via the miR-214-3p/Wnt3/β-catenin pathway.
Zhuang JB, Li T, Hu XM, Ning M, Gao WQ, Lang YH, Zheng WF, Wei J. | 02/13/2021 |
| Lower CHFR expression was independently associated with unfavorable prognosis in acute myeloid leukemia. Moreover, aberrant CHFR promoter methylation was a rare event in myeloid malignances. | Methylation-independent CHFR expression is a potential biomarker affecting prognosis in acute myeloid leukemia.
Zhou JD, Zhang TJ, Li XX, Ma JC, Guo H, Wen XM, Yao DM, Zhang W, Lin J, Qian J. | 04/20/2019 |
| The results establish a firm molecular link in immune-edited tumor cells among NANOG, AKT, CHFR, and HDAC1, identifying HDAC1 as a molecular target in controlling NANOGHIGH immune-refractory cancer. | Stabilization of HDAC1 via TCL1-pAKT-CHFR axis is a key element for NANOG-mediated multi-resistance and stem-like phenotype in immune-edited tumor cells.
Woo SR, Lee HJ, Oh SJ, Kim S, Park SH, Lee J, Song KH, Kim TW. | 03/16/2019 |
| These data suggest that CHFR methylation may be associated with favorable treatment outcomes of irinotecan-based chemotherapy in patients with metastatic colorectal cancer. | Association of CHFR Promoter Methylation with Treatment Outcomes of Irinotecan-Based Chemotherapy in Metastatic Colorectal Cancer.
Cha Y, Kim SY, Yeo HY, Baek JY, Choi MK, Jung KH, Dong SM, Chang HJ., Free PMC Article | 02/16/2019 |
| JNK inhibitor prevents SIRT1 phosphorylation, leading to elevated SIRT1 protein levels even in the presence of H2O2. Taken together, our results indicate that CHFR plays a crucial role in the cellular stress response pathway by controlling the stability and function of SIRT1. | CHFR negatively regulates SIRT1 activity upon oxidative stress.
Kim M, Kwon YE, Song JO, Bae SJ, Seol JH., Free PMC Article | 05/26/2018 |
| Re-expression of CHFR in miR-26a overexpressing cells partially rescues normal mitosis and impairs the tumorigenesis exerted by miR-26a. | Sustained expression of miR-26a promotes chromosomal instability and tumorigenesis through regulation of CHFR.
Castellano L, Dabrowska A, Pellegrino L, Ottaviani S, Cathcart P, Frampton AE, Krell J, Stebbing J., Free PMC Article | 09/16/2017 |
| Data show that hypermethylation of the CHFR promoter, frequent in acute myeloid leukemia, is associated with adverse outcome, and can thus be used for risk stratification. | CHFR hypermethylation, a frequent event in acute myeloid leukemia, is independently associated with an adverse outcome.
Gao L, Liu F, Zhang H, Sun J, Ma Y. | 10/22/2016 |
| Small molecule inhibition of CHFR-PARP1 interaction is a novel potential therapeutic approach to increase the efficacy of taxane-based chemotherapy in cancer. | Small molecule inhibition of the CHFR-PARP1 interaction as novel approach to overcome intrinsic taxane resistance in cancer.
Brodie SA, Li G, Harvey D, Khuri FR, Vertino PM, Brandes JC., Free PMC Article | 08/6/2016 |
| CHFR unmethylation is associated with oxaliplatin resistance in gastric cancer. | Predictive value of CHFR and MLH1 methylation in human gastric cancer.
Li Y, Yang Y, Lu Y, Herman JG, Brock MV, Zhao P, Guo M., Free PMC Article | 01/16/2016 |
| CHFR methylation has a role in methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer | CHFR methylation strongly correlates with methylation of DNA damage repair and apoptotic pathway genes in non-small cell lung cancer.
Guo M, Alumkal J, Drachova T, Gao D, Marina SS, Jen J, Herman JG. | 01/2/2016 |
| CHFR promoter methylation is associated with colorectal cancer. | CHFR promoter methylation indicates poor prognosis in stage II microsatellite stable colorectal cancer.
Cleven AH, Derks S, Draht MX, Smits KM, Melotte V, Van Neste L, Tournier B, Jooste V, Chapusot C, Weijenberg MP, Herman JG, de Bruïne AP, van Engeland M. | 10/17/2015 |
| CHFR-PAX5 fusion transcript is associated with B-cell precursor acute lymphoblastic leukemia. | Three novel fusion transcripts of the paired box 5 gene in B-cell precursor acute lymphoblastic leukemia.
Fazio G, Daniele G, Cazzaniga V, Impera L, Severgnini M, Iacobucci I, Galbiati M, Leszl A, Cifola I, De Bellis G, Bresciani P, Martinelli G, Basso G, Biondi A, Storlazzi CT, Cazzaniga G., Free PMC Article | 10/17/2015 |
| Aberrant methylation of CHFR may be associated with the pathogenesis, progression for B-cell non-Hodgkin lymphoma(B-NHL), which might be a novel molecular marker as prognosis and treatment for B-NHL. | Aberrant expression of the CHFR prophase checkpoint gene in human B-cell non-Hodgkin lymphoma.
Song A, Ye J, Zhang K, Yu H, Gao Y, Wang H, Sun L, Xing X, Yang K, Zhao M. | 08/8/2015 |
| Studies indicate that checkpoint with forkhead and ring finger domains (CHFR) promoter CpG island methylation as prognostic marker. | Emerging evidence for CHFR as a cancer biomarker: from tumor biology to precision medicine.
Derks S, Cleven AH, Melotte V, Smits KM, Brandes JC, Azad N, van Criekinge W, de Bruïne AP, Herman JG, van Engeland M., Free PMC Article | 06/27/2015 |
| CHFR ubiquitinates and regulates TOPK levels, which is essential for its checkpoint function. | TOPK and PTEN participate in CHFR mediated mitotic checkpoint.
Shinde SR, Gangula NR, Kavela S, Pandey V, Maddika S., Free PMC Article | 12/6/2014 |
| CHFR methylation may have a role in chemosensitivity of paclitaxel in advanced gastric cancer | Association between CHFR methylation and chemosensitivity of paclitaxel in advanced gastric cancer.
Wang M, Shen L, Deng D. | 10/25/2014 |
| CHFR methylation in CRC cell lines predicted for sensitivity in vitro and in vivo to docetaxel, while MSI-H cell lines were more sensitive to gemcitabine | CHFR silencing or microsatellite instability is associated with increased antitumor activity of docetaxel or gemcitabine in colorectal cancer.
Pelosof L, Yerram SR, Ahuja N, Delmas A, Danilova L, Herman JG, Azad NS., Free PMC Article | 01/18/2014 |
| CHFR expression is a novel predictive marker of response and overall survival in NSCLC patients treated with taxane-containing chemotherapy | CHFR protein expression predicts outcomes to taxane-based first line therapy in metastatic NSCLC.
Pillai RN, Brodie SA, Sica GL, Shaojin Y, Li G, Nickleach DC, Yuan L, Varma VA, Bonta D, Herman JG, Brock MV, Ribeiro MJ, Ramalingam SS, Owonikoko TK, Khuri FR, Brandes JC., Free PMC Article | 09/28/2013 |