| The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease. | The impact of VPS35 D620N mutation on alternative autophagy and its reversal by estrogen in Parkinson's disease.
Shiraishi T, Bono K, Hiraki H, Manome Y, Oka H, Iguchi Y, Okano HJ., Free PMC Article | 02/29/2024 |
| VPS35 and retromer dysfunction in Parkinson's disease. | VPS35 and retromer dysfunction in Parkinson's disease.
Rowlands J, Moore DJ., Free PMC Article | 02/21/2024 |
| VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner. | VPS35 promotes gastric cancer progression through integrin/FAK/SRC signalling-mediated IL-6/STAT3 pathway activation in a YAP-dependent manner.
Zhou Q, Qi F, Zhou C, Ji J, Jiang J, Wang C, Zhao Q, Jin Y, Wu J, Cai Q, Tian H, Zhang J., Free PMC Article | 01/15/2024 |
| VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer. | VPS35 promotes cell proliferation via EGFR recycling and enhances EGFR inhibitors response in gastric cancer.
Yu J, Feng H, Sang Q, Li F, Chen M, Yu B, Xu Z, Pan T, Wu X, Hou J, Zhu Z, Yan C, Su L, Li J, Liu B., Free PMC Article | 10/28/2023 |
| Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches. | Structural and Functional Impact of Damaging Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) on Human VPS35 Protein Using Computational Approaches.
Jawad Ul Hasnain M, Amin F, Ghani A, Ahmad S, Rahman Z, Aslam T, Pervez MT. | 04/7/2023 |
| Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway. | Mutant VPS35-D620N induces motor dysfunction and impairs DAT-mediated dopamine recycling pathway.
Huang Y, Huang H, Zhou L, Li J, Chen X, Thomas J, He X, Guo W, Zeng Y, Low BC, Liang F, Zeng J, Ross CA, Tan EK, Smith W, Pei Z. | 11/26/2022 |
| ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells. | ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells.
Hong X, Wang T, Du J, Hong Y, Yang CP, Xiao W, Li Y, Wang M, Sun H, Deng ZH., Free PMC Article | 06/18/2022 |
| Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition. | Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition.
Kadgien CA, Kamesh A, Milnerwood AJ., Free PMC Article | 04/9/2022 |
| Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP. | Impaired neurogenesis in the hippocampus of an adult VPS35 mutant mouse model of Parkinson's disease through interaction with APP.
Jiang M, Tu HT, Zhang K, Zhang W, Yu WP, Xu J, Tan EK, Guo KH, Zeng L. | 01/29/2022 |
| VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells. | VPS35 Downregulation Alters Degradation Pathways in Neuronal Cells.
Filippone A, Li JG, Praticò D., Free PMC Article | 01/22/2022 |
| Clinical manifestations of Parkinson's disease harboring VPS35 retromer complex component p.D620N with long-term follow-up. | Clinical manifestations of Parkinson's disease harboring VPS35 retromer complex component p.D620N with long-term follow-up.
Ishiguro M, Li Y, Yoshino H, Daida K, Ishiguro Y, Oyama G, Saiki S, Funayama M, Hattori N, Nishioka K. | 01/1/2022 |
| Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy. | Parkinson's disease-associated VPS35 mutant reduces mitochondrial membrane potential and impairs PINK1/Parkin-mediated mitophagy.
Ma KY, Fokkens MR, Reggiori F, Mari M, Verbeek DS., Free PMC Article | 12/25/2021 |
| Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N. | Endosomal dysfunction in iPSC-derived neural cells from Parkinson's disease patients with VPS35 D620N.
Bono K, Hara-Miyauchi C, Sumi S, Oka H, Iguchi Y, Okano HJ., Free PMC Article | 07/10/2021 |
| Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N. | Enhanced Hyaluronan Signaling and Autophagy Dysfunction by VPS35 D620N.
Rahman AA, Soto-Avellaneda A, Yong Jin H, Stojkovska I, Lai NK, Albright JE, Webb AR, Oe E, Valarde JP, Oxford AE, Urquhart PE, Wagner B, Brown C, Amado I, Vasquez P, Lehning N, Grozdanov V, Pu X, Danzer KM, Morrison BE., Free PMC Article | 06/26/2021 |
| Formation of retromer transport carriers is disrupted by the Parkinson disease-linked Vps35 D620N variant. | Formation of retromer transport carriers is disrupted by the Parkinson disease-linked Vps35 D620N variant.
Cui Y, Yang Z, Flores-Rodriguez N, Follett J, Ariotti N, Wall AA, Parton RG, Teasdale RD. | 05/15/2021 |
| Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons. | Mitochondrial and Clearance Impairment in p.D620N VPS35 Patient-Derived Neurons.
Hanss Z, Larsen SB, Antony P, Mencke P, Massart F, Jarazo J, Schwamborn JC, Barbuti PA, Mellick GD, Krüger R., Free PMC Article | 05/8/2021 |
| Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread. | Parkinson's Disease Causative Mutation in Vps35 Disturbs Tetherin Trafficking to Cell Surfaces and Facilitates Virus Spread.
Ding Y, Li Y, Chhetri G, Peng X, Wu J, Wang Z, Zhao B, Zhao W, Li X., Free PMC Article | 04/17/2021 |
| DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma. | DNA and RNA sequencing identified a novel oncogene VPS35 in liver hepatocellular carcinoma.
Zhang G, Tang X, Liang L, Zhang W, Li D, Li X, Zhao D, Zheng Y, Chen Y, Hao B, Wang K, Tang N, Ding K. | 11/28/2020 |
| Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis. | Retromer stabilization results in neuroprotection in a model of Amyotrophic Lateral Sclerosis.
Muzio L, Sirtori R, Gornati D, Eleuteri S, Fossaghi A, Brancaccio D, Manzoni L, Ottoboni L, Feo L, Quattrini A, Mastrangelo E, Sorrentino L, Scalone E, Comi G, Marinelli L, Riva N, Milani M, Seneci P, Martino G., Free PMC Article | 09/12/2020 |
| LRRK2-mediated Rab10 phosphorylation is increased in neutrophils as well as monocytes isolated from three Parkinson's patients with a heterozygous VPS35[D620N] mutation. | The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
Mir R, Tonelli F, Lis P, Macartney T, Polinski NK, Martinez TN, Chou MY, Howden AJM, König T, Hotzy C, Milenkovic I, Brücke T, Zimprich A, Sammler E, Alessi DR., Free PMC Article | 05/25/2019 |
| a novel regulator of N-Ras trafficking and signaling | Where no Ras has gone before: VPS35 steers N-Ras through the cytosol.
Zhou M, Philips MR., Free PMC Article | 03/9/2019 |
| these results suggest that VPS35 D620N mutation-induced excessive mitochondrial fission leads to the defects in the assembled complex I and supercomplex and causes bioenergetics deficits. | Parkinson's disease-associated pathogenic VPS35 mutation causes complex I deficits.
Zhou L, Wang W, Hoppel C, Liu J, Zhu X., Free PMC Article | 12/1/2018 |
| These experimental data establish the retromer complex as a key spatiotemporal regulator of IFNAR endosomal sorting and a new factor in type-I IFN-induced JAK/STAT signalling and gene transcription. | Spatiotemporal control of interferon-induced JAK/STAT signalling and gene transcription by the retromer complex.
Chmiest D, Sharma N, Zanin N, Viaris de Lesegno C, Shafaq-Zadah M, Sibut V, Dingli F, Hupé P, Wilmes S, Piehler J, Loew D, Johannes L, Schreiber G, Lamaze C., Free PMC Article | 09/8/2018 |
| Present data support a role for perturbed VPS35 and retromer function in the pathogenesis of Parkinson's disease. | VPS35, the Retromer Complex and Parkinson's Disease.
Williams ET, Chen X, Moore DJ., Free PMC Article | 02/3/2018 |
| These findings provide new mechanistic insights into the role of VPS35 in the regulation of AIMP2 levels and cell death. | VPS35 regulates parkin substrate AIMP2 toxicity by facilitating lysosomal clearance of AIMP2.
Yun SP, Kim H, Ham S, Kwon SH, Lee GH, Shin JH, Lee SH, Ko HS, Lee Y., Free PMC Article | 11/25/2017 |