| MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression. | MicroRNA-409-5p Inhibits GIST Tumorigenesis and Improves Imatinib Resistance by Targeting KDM4D Expression.
Qiu C, Feng YD, Yang X. | 11/18/2023 |
| KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5. | KDM4D enhances osteo/dentinogenic differentiation and migration of SCAPs via binding to RPS5.
Liang H, Li Q, Wang N, Wang C, Shi S, Yang H, Cao Y, Shi R, Jin L, Zhang C. | 11/3/2023 |
| Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression. | Histone demethylase JMJD2D promotes the self-renewal of liver cancer stem-like cells by enhancing EpCAM and Sox9 expression.
Deng Y, Li M, Zhuo M, Guo P, Chen Q, Mo P, Li W, Yu C., Free PMC Article | 08/21/2021 |
| Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression. | Demethylase-independent function of JMJD2D as a novel antagonist of p53 to promote Liver Cancer initiation and progression.
Li M, Deng Y, Zhuo M, Zhou H, Kong X, Xia X, Su Z, Chen Q, Guo P, Mo P, Yu C, Li W., Free PMC Article | 05/22/2021 |
| Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression. | Histone demethylase JMJD2D activates HIF1 signaling pathway via multiple mechanisms to promote colorectal cancer glycolysis and progression.
Peng K, Zhuo M, Li M, Chen Q, Mo P, Yu C. | 12/12/2020 |
| Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling. | Inflammation-induced JMJD2D promotes colitis recovery and colon tumorigenesis by activating Hedgehog signaling.
Zhuo M, Chen W, Shang S, Guo P, Peng K, Li M, Mo P, Zhang Y, Qiu X, Li W, Yu C. | 11/28/2020 |
| KDM4D facilitates TLR4 transcription through demethylation of H3K9, thus activating TLR4/NF-kappaB signaling pathways in hepatic stellate cells, contributing to HSC activation and collagen crosslinking, further, hepatic fibrosis progression. | The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway.
Dong F, Jiang S, Li J, Wang Y, Zhu L, Huang Y, Jiang X, Hu X, Zhou Q, Zhang Z, Bao Z., Free PMC Article | 06/15/2019 |
| Results demonstrate that KDM4D mRNA and protein levels are upregulated in gastrointestinal stromal tumour (GIST). Its overexpression strongly promotes GIST cell proliferation, migration, invasion and angiogenesis. In contrast, its silencing reduced cell proliferation, migration, invasion and tumor angiogenesis. More importantly, these effects mediated by KDM4D might be dependent on the Hif1beta/VEGFA signaling pathway. | Histone demethylase KDM4D promotes gastrointestinal stromal tumor progression through HIF1β/VEGFA signalling.
Hu F, Li H, Liu L, Xu F, Lai S, Luo X, Hu J, Yang X., Free PMC Article | 03/23/2019 |
| A high nuclear expression of KDM4D in samples of pancreatic resection margins significantly and independently predicted an earlier recurrence and could thus be used in the assessment of risk of relapse in clinical practice. | KDM4D Predicts Recurrence in Exocrine Pancreatic Cells of Resection Margins from Patients with Pancreatic Adenocarcinoma.
Isohookana J, Haapasaari KM, Soini Y, Karihtala P. | 04/14/2018 |
| The results demonstrate a novel mechanism by which Kdm4d regulates DNA replication by reducing the H3K9me3 level to facilitate formation of preinitiation complex. | H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication.
Wu R, Wang Z, Zhang H, Gan H, Zhang Z., Free PMC Article | 06/24/2017 |
| KDM4B and KDM4D expression may associate with an aggressive subtype of classical Hodgkin lymphoma and be linked with radioresistance | Strong KDM4B and KDM4D Expression Associates with Radioresistance and Aggressive Phenotype in Classical Hodgkin Lymphoma.
Bur H, Haapasaari KM, Turpeenniemi-Hujanen T, Kuittinen O, Auvinen P, Marin K, Soini Y, Karihtala P. | 02/18/2017 |
| KDM4D-RNA interaction is required for KDM4D accumulation at DNA breakage sites | The emerging role of lysine demethylases in DNA damage response: dissecting the recruitment mode of KDM4D/JMJD2D to DNA damage sites.
Khoury-Haddad H, Nadar-Ponniah PT, Awwad S, Ayoub N., Free PMC Article | 01/2/2016 |
| PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair. | PARP1-dependent recruitment of KDM4D histone demethylase to DNA damage sites promotes double-strand break repair.
Khoury-Haddad H, Guttmann-Raviv N, Ipenberg I, Huggins D, Jeyasekharan AD, Ayoub N., Free PMC Article | 04/19/2014 |
| The molecular basis for JMJD2 site specificity revealed by X-ray crystallography. | Structural and functional analysis of JMJD2D reveals molecular basis for site-specific demethylation among JMJD2 demethylases.
Krishnan S, Trievel RC. | 07/6/2013 |
| Results demonstrate that JMJD2D can stimulate cell proliferation and survival, suggesting that its inhibition may be helpful in the fight against cancer | Regulation of tumor suppressor p53 and HCT116 cell physiology by histone demethylase JMJD2D/KDM4D.
Kim TD, Oh S, Shin S, Janknecht R., Free PMC Article | 09/1/2012 |
| identified two related histone demethylases, JMJD2A and JMJD2D | Activation of androgen receptor by histone demethylases JMJD2A and JMJD2D.
Shin S, Janknecht R. | 01/21/2010 |