| PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer. | PEX26 Functions as a Metastasis Suppressor in Colorectal Cancer.
Yan B, Cao L, Gao L, Wei S, Wang M, Tian Y, Yang J, Chen E. | 01/17/2024 |
| Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance. | Silencing PEX26 as an unconventional mode to kill drug-resistant cancer cells and forestall drug resistance.
Dahabieh MS, Huang F, Goncalves C, Flores González RE, Prabhu S, Bolt A, Di Pietro E, Khoury E, Heath J, Xu ZY, Rémy-Sarrazin J, Mann KK, Orthwein A, Boisvert FM, Braverman N, Miller WH, Del Rincón SV., Free PMC Article | 04/30/2022 |
| There are no significant differences between PEX1-, PEX6-, and PEX26-associated phenotypes inclinical and genetic spectrum of Heimler syndrome. | Expanding the clinical and genetic spectrum of Heimler syndrome.
Gao FJ, Hu FY, Xu P, Qi YH, Li JK, Zhang YJ, Chen F, Chang Q, Song F, Shen SM, Xu GZ, Wu JH., Free PMC Article | 08/1/2020 |
| An autosomal recessive missense variant, c.153C>A (p.F51L) in PEX26 was identified in Ashkenazi Jewish individual with a milder form of Zellweger spectrum and hearing loss. Binding of Pex26-F51L to Pex1 and Pex6 is severely impaired and affects peroxisome assembly. Pex26 in the patient's fibroblasts is reduced to approximately 30% of control, suggesting that Pex26-F51L is unstable in cells. There are also other changes... | A newly identified mutation in the PEX26 gene is associated with a milder form of Zellweger spectrum disorder.
Tanaka AJ, Okumoto K, Tamura S, Abe Y, Hirsch Y, Deng L, Ekstein J, Chung WK, Fujiki Y., Free PMC Article | 04/4/2020 |
| Data support an alternative PEX14-dependent mechanism of peroxisomal membrane association for the splice variant, which lacks a transmembrane domain. Structure-function relationships of PEX26 isoforms explain an extended function in peroxisomal homeostasis and these findings may improve our understanding of the broad phenotype of PEX26-associated human disorders. | Isoform-specific domain organization determines conformation and function of the peroxisomal biogenesis factor PEX26.
Guder P, Lotz-Havla AS, Woidy M, Reiß DD, Danecka MK, Schatz UA, Becker M, Ensenauer R, Pagel P, Büttner L, Muntau AC, Gersting SW. | 09/14/2019 |
| In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner. | Conserved targeting information in mammalian and fungal peroxisomal tail-anchored proteins.
Buentzel J, Vilardi F, Lotz-Havla A, Gärtner J, Thoms S., Free PMC Article | 10/1/2016 |
| results suggested that peroxisome biogenesis requires Pex1p- and Pex6p-regulated dissociation of Pex14p from Pex26p | AAA peroxins and their recruiter Pex26p modulate the interactions of peroxins involved in peroxisomal protein import.
Tamura S, Matsumoto N, Takeba R, Fujiki Y., Free PMC Article | 01/24/2015 |
| PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. | Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway.
Yagita Y, Hiromasa T, Fujiki Y., Free PMC Article | 04/27/2013 |
| the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX26 gene. | Identification of novel mutations and sequence variation in the Zellweger syndrome spectrum of peroxisome biogenesis disorders.
Yik WY, Steinberg SJ, Moser AB, Moser HW, Hacia JG., Free PMC Article | 01/21/2010 |
| We analyzed targeting of human PEX26. Its C-terminal-targeting signal contains two binding sites for PEX19 and we conclude C-terminal PEX19-binding sites mark tail-anchored proteins for delivery to peroxisomes. | Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites.
Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer-Engert R, Erdmann R, Rottensteiner H. | 01/21/2010 |
| Pex26p functions in recruiting to peroxisomes the complexes of the AAA ATPase peroxins. | Mutations in the peroxin Pex26p responsible for peroxisome biogenesis disorders of complementation group 8 impair its stability, peroxisomal localization, and interaction with the Pex1p x Pex6p complex.
Furuki S, Tamura S, Matsumoto N, Miyata N, Moser A, Moser HW, Fujiki Y. | 01/21/2010 |
| PEX26 deficiency impairs peroxisomal import of both PTS1- and PTS2-targeted matrix proteins. It undergoes alternative splicing to produce several splice forms, including PEX26-delta, which rescues peroxisome biogenesis in PEX26-deficient cells. | Alternative splicing suggests extended function of PEX26 in peroxisome biogenesis.
Weller S, Cajigas I, Morrell J, Obie C, Steel G, Gould SJ, Valle D., Free PMC Article | 01/21/2010 |
| degree of temperature sensitivity in pex26 cell lines is predictive of the clinical phenotype in patients with PEX26 deficiency | Mutations in novel peroxin gene PEX26 that cause peroxisome-biogenesis disorders of complementation group 8 provide a genotype-phenotype correlation.
Matsumoto N, Tamura S, Furuki S, Miyata N, Moser A, Shimozawa N, Moser HW, Suzuki Y, Kondo N, Fujiki Y., Free PMC Article | 01/21/2010 |